Innovative Technologies in Nanomedicines: From Passive Targeting to Active Targeting/From Controlled Pharmacokinetics to Controlled Intracellular Pharmacokinetics

Cellular environment-responsive nanomaterials for use in gene and siRNA delivery: molecular design for biomembrane destabilization and intracellular collapse

(2016) Hiroki Tanaka et al.   Expert Opinion on Drug Delivery

A lipid nanoparticle for the efficient delivery of siRNA to dendritic cells

(2016) Shota Warashina et al.   JOURNAL OF CONTROLLED RELEASE

Elucidation of the physicochemical properties and potency of siRNA-loaded small-sized lipid nanoparticles for siRNA delivery

(2016) Yusuke Sato et al.   JOURNAL OF CONTROLLED RELEASE

Novel pH-sensitive multifunctional envelope-type nanodevice for siRNA-based treatments for chronic HBV infection

(2016) Naoki Yamamoto et al.   JOURNAL OF HEPATOLOGY

Relationship Between the Physicochemical Properties of Lipid Nanoparticles and the Quality of siRNA Delivery to Liver Cells

(2016) Yusuke Sato et al.   MOLECULAR THERAPY

Multifunctional Envelope-Type Nano Device: Evolution from Nonselective to Active Targeting System

(2015) Yasuhiro Hayashi et al.   BIOCONJUGATE CHEMISTRY

Mitochondrial delivery of antisense RNA by MITO-Porter results in mitochondrial RNA knockdown, and has a functional impact on mitochondria

(2015) Ryo Furukawa et al.   BIOMATERIALS

The intracellular pharmacodynamics of siRNA is responsible for the low gene silencing activity of siRNA-loaded nanoparticles in dendritic cells

(2015) Takashi Nakamura et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Effect of hydrophobic scaffold on the cellular uptake and gene transfection activities of DNA-encapsulating liposomal nanoparticles via intracerebroventricular administration

(2015) Hidetaka Akita et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

A neutral lipid envelope-type nanoparticle composed of a pH-activated and vitamin E-scaffold lipid-like material as a platform for a gene carrier targeting renal cell carcinoma

(2015) Hidetaka Akita et al.   JOURNAL OF CONTROLLED RELEASE

Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma

(2015) Takashi Nakamura et al.   JOURNAL OF CONTROLLED RELEASE

Gemini Surfactants Mediate Efficient Mitochondrial Gene Delivery and Expression

(2015) Ana M. Cardoso et al.   MOLECULAR PHARMACEUTICS

Validation of Mitochondrial Gene Delivery in Liver and Skeletal Muscle via Hydrodynamic Injection Using an Artificial Mitochondrial Reporter DNA Vector

(2015) Yukari Yasuzaki et al.   MOLECULAR PHARMACEUTICS

Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown

(2015) Anders Wittrup et al.   NATURE BIOTECHNOLOGY

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

(2015) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

PLK1 is a critical determinant of tumor cell sensitivity to CPT11 and its inhibition enhances the drug antitumor efficacy in squamous cell carcinoma models sensitive and resistant to camptothecins

(2015) Valentina Zuco et al.   Oncotarget

Molecular Tuning of a Vitamin E-Scaffold pH-Sensitive and Reductive Cleavable Lipid-like Material for Accelerated in Vivo Hepatic siRNA Delivery

(2015) Hidetaka Akita et al.   ACS Biomaterials-Science & Engineering

Molecular Tuning of a Vitamin E-Scaffold pH-Sensitive and Reductive Cleavable Lipid-like Material for Accelerated in Vivo Hepatic siRNA Delivery

(2015) Hidetaka Akita et al.   ACS Biomaterials Science & Engineering

An aptamer ligand based liposomal nanocarrier system that targets tumor endothelial cells

(2014) Mst. Naznin Ara et al.   BIOMATERIALS

Advances in an active and passive targeting to tumor and adipose tissues

(2014) Yu Sakurai et al.   Expert Opinion on Drug Delivery

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

Multifunctional envelope-type nano device for controlled intracellular trafficking and selective targeting in vivo

(2014) Kazuaki Kajimoto et al.   JOURNAL OF CONTROLLED RELEASE

A new adjuvant delivery system ‘cyclic di-GMP/YSK05 liposome’ for cancer immunotherapy

(2014) Hiroko Miyabe et al.   JOURNAL OF CONTROLLED RELEASE

Comparative assessments of crucial factors for a functional ligand-targeted nanocarrier

(2014) Md. Nazir Hossen et al.   JOURNAL OF DRUG TARGETING

Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2014) Marie Ng et al.   LANCET

Quantitation of Physiological and Biochemical Barriers to siRNA Liver Delivery via Lipid Nanoparticle Platform

(2014) Yan Xu et al.   MOLECULAR PHARMACEUTICS

Improvement of Doxorubicin Efficacy Using Liposomal Anti-Polo-like Kinase 1 siRNA in Human Renal Cell Carcinomas

(2014) Yu Sakurai et al.   MOLECULAR PHARMACEUTICS

Non-viral vectors for gene-based therapy

(2014) Hao Yin et al.   NATURE REVIEWS GENETICS

Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates

(2014) Y. Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus.

(2014) Tsunamasa Watanabe et al.   Scientific Reports

Neutralized Nanoparticle Composed of SS-Cleavable and pH-Activated Lipid-Like Material as a Long-Lasting and Liver-Specific Gene Delivery System

(2014) Masami Ukawa et al.   Advanced Healthcare Materials

Identification and expression of troponin T, a new marker on the surface of cultured tumor endothelial cells by aptamer ligand

(2014) Mst. Naznin Ara et al.   Cancer Medicine

Nanopreparations for organelle-specific delivery in cancer

(2013) Swati Biswas et al.   ADVANCED DRUG DELIVERY REVIEWS

Neutral biodegradable lipid-envelope-type nanoparticle using vitamin A-Scaffold for nuclear targeting of plasmid DNA

(2013) Hiroki Tanaka et al.   BIOMATERIALS

Programmed nanoparticles for combined immunomodulation, antigen presentation and tracking of immunotherapeutic cells

(2013) Min Beom Heo et al.   BIOMATERIALS

TLR9-mediated siRNA delivery for targeting of normal and malignant human hematopoietic cells in vivo

(2013) Q. Zhang et al.   BLOOD

Exploiting the curative potential of adoptive T-cell therapy for cancer

(2013) Christian S. Hinrichs et al.   IMMUNOLOGICAL REVIEWS

Long-term Drug Treatment for Obesity

(2013) Susan Z. Yanovski et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Localization of exogenous DNA to mitochondria in skeletal muscle following hydrodynamic limb vein injection

(2013) Yukari Yasuzaki et al.   JOURNAL OF CONTROLLED RELEASE

A comparative study between nanoparticle-targeted therapeutics and bioconjugates as obesity medication

(2013) Md. Nazir Hossen et al.   JOURNAL OF CONTROLLED RELEASE

RNAi-mediated gene knockdown and anti-angiogenic therapy of RCCs using a cyclic RGD-modified liposomal-siRNA system

(2013) Yu Sakurai et al.   JOURNAL OF CONTROLLED RELEASE

Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics

(2013) Martin A Maier et al.   MOLECULAR THERAPY

Gene Silencing via RNAi and siRNA Quantification in Tumor Tissue Using MEND, a Liposomal siRNA Delivery System

(2013) Yu Sakurai et al.   MOLECULAR THERAPY

Therapeutic Assessment of Cytochrome C for the Prevention of Obesity Through Endothelial Cell-targeted Nanoparticulate System

(2013) Md. Nazir Hossen et al.   MOLECULAR THERAPY

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

(2013) Jerome Gilleron et al.   NATURE BIOTECHNOLOGY

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

(2013) Gaurav Sahay et al.   NATURE BIOTECHNOLOGY

A Neutral Envelope-Type Nanoparticle Containing pH-Responsive and SS-Cleavable Lipid-Like Material as a Carrier for Plasmid DNA

(2013) Hidetaka Akita et al.   Advanced Healthcare Materials

Lipid Nanoparticle Delivery of siRNA to Silence Neuronal Gene Expression in the Brain

(2013) Ravi L Rungta et al.   Molecular Therapy-Nucleic Acids

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

(2012) Muthusamy Jayaraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis, Characterization, and Evaluation of Ionizable Lysine-Based Lipids for siRNA Delivery

(2012) Colin L. Walsh et al.   BIOCONJUGATE CHEMISTRY

Lipid nanoparticles for hepatic delivery of small interfering RNA

(2012) Bo Yu et al.   BIOMATERIALS

Improving dendritic cell vaccine immunogenicity by silencing PD-1 ligands using siRNA-lipid nanoparticles combined with antigen mRNA electroporation

(2012) Willemijn Hobo et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The Vascular Endothelium of the Adipose Tissue Gives Rise to Both White and Brown Fat Cells

(2012) Khanh-Van Tran et al.   Cell Metabolism

Vascular-targeted nanotherapy for obesity: Unexpected passive targeting mechanism to obese fat for the enhancement of active drug delivery

(2012) Md. Nazir Hossen et al.   JOURNAL OF CONTROLLED RELEASE

A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo

(2012) Yusuke Sato et al.   JOURNAL OF CONTROLLED RELEASE

Bottom-Up Design and Synthesis of Limit Size Lipid Nanoparticle Systems with Aqueous and Triglyceride Cores Using Millisecond Microfluidic Mixing

(2012) Igor V. Zhigaltsev et al.   LANGMUIR

The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response

(2012) Kislay Parvatiyar et al.   NATURE IMMUNOLOGY

Development of a Novel DNA Aptamer Ligand Targeting to Primary Cultured Tumor Endothelial Cells by a Cell-Based SELEX Method

(2012) Mst. Naznin Ara et al.   PLoS One

Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber's hereditary optic neuropathy in a mouse model

(2012) H. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA

(2012) Nathan M Belliveau et al.   Molecular Therapy-Nucleic Acids

Matrix metalloproteinase inhibition impairs murine adipose tissue development independently of leptin

(2011) Matthias Van Hul et al.   ENDOCRINE JOURNAL

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

(2011) H. Cabral et al.   Nature Nanotechnology

Expression of GFP in the Mitochondrial Compartment Using DQAsome-Mediated Delivery of an Artificial Mini-mitochondrial Genome

(2011) Diana Lyrawati et al.   PHARMACEUTICAL RESEARCH

Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients

(2011) F. I. Staquicini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Peptidomimetic Targeting White Fat Causes Weight Loss and Improved Insulin Resistance in Obese Monkeys

(2011) K. F. Barnhart et al.   Science Translational Medicine

Nanoparticle targeting using multivalent ligands: computer modeling

(2011) Shihu Wang et al.   Soft Matter

Blockade of B7-H1 enhances dendritic cell-mediated T cell response and antiviral immunity in HBV transgenic mice

(2011) Wenzheng Jiang   VACCINE

Mitochondrial matrix delivery using MITO-Porter, a liposome-based carrier that specifies fusion with mitochondrial membranes

(2010) Yukari Yasuzaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting neuropilin-1 in human leukemia and lymphoma

(2010) K. Karjalainen et al.   BLOOD

Peptide Designed to Elicit Apoptosis in Adipose Tissue Endothelium Reduces Food Intake and Body Weight

(2010) D.-H. Kim et al.   DIABETES

Newly developed strategies for multifunctional mitochondria-targeted agents in cancer therapy

(2010) Erlong Zhang et al.   DRUG DISCOVERY TODAY

The anti-angiogenic herbal composition Ob-X inhibits adipose tissue growth in obese mice

(2010) M-Y Kim et al.   INTERNATIONAL JOURNAL OF OBESITY

Ligand-based targeted delivery of a peptide modified nanocarrier to endothelial cells in adipose tissue

(2010) Md. Nazir Hossen et al.   JOURNAL OF CONTROLLED RELEASE

Isolation and culture of microvascular endothelial cells from murine inguinal and epididymal adipose tissues

(2010) Kazuaki Kajimoto et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Lipid-like materials for low-dose, in vivo gene silencing

(2010) K. T. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial DNA mutations and human disease

(2009) Helen A.L. Tuppen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Immune modulation through RNA interference-mediated silencing of CD40 in dendritic cells

(2009) Mohammad Hossein Karimi et al.   CELLULAR IMMUNOLOGY

Curcumin Inhibits Adipogenesis in 3T3-L1 Adipocytes and Angiogenesis and Obesity in C57/BL Mice

(2009) Asma Ejaz et al.   JOURNAL OF NUTRITION

Angiogenesis and development of adipose tissue

(2009) V. Christiaens et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The size of endothelial fenestrae in human liver sinusoids: implications for hepatocyte-directed gene transfer

(2008) E Wisse et al.   GENE THERAPY

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

(2008) Akin Akinc et al.   NATURE BIOTECHNOLOGY

A20 is an antigen presentation attenuator and its inhibition overcomes regulatory T cell–mediated suppression

(2008) Xiao-Tong Song et al.   NATURE MEDICINE

MITO-Porter: A liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion

(2007) Yuma Yamada et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES