CODV-Ig, a universal bispecific tetravalent and multifunctional immunoglobulin format for medical applications

Mechanism of Immobilized Protein A Binding to Immunoglobulin G on Nanosensor Array Surfaces

(2015) Justin T. Nelson et al.   ANALYTICAL CHEMISTRY

Improving target cell specificity using a novel monovalent bispecific IgG design

(2015) Yariv Mazor et al.   mAbs

Insights into the molecular basis of a bispecific antibody's target selectivity

(2015) Yariv Mazor et al.   mAbs

Engineered antibody domains with significantly increased transcytosis and half-life in macaques mediated by FcRn

(2015) Tianlei Ying et al.   mAbs

A bispecific antibody targeting CD47 and CD20 selectively binds and eliminates dual antigen expressing lymphoma cells

(2015) Emily C Piccione et al.   mAbs

Protein design of IgG/TCR chimeras for the co-expression of Fab-like moieties within bispecific antibodies

(2015) Xiufeng Wu et al.   mAbs

The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity

(2015) Yasmina Noubia Abdiche et al.   mAbs

Suppression of conformational heterogeneity at a protein–protein interface

(2015) Lindsay N. Deis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-CD20/CD3 T cell–dependent bispecific antibody for the treatment of B cell malignancies

(2015) Liping L. Sun et al.   Science Translational Medicine

A CD3xCD123 bispecific DART for redirecting host T cells to myelogenous leukemia: Preclinical activity and safety in nonhuman primates

(2015) Gurunadh R. Chichili et al.   Science Translational Medicine

Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface

(2014) Steven M Lewis et al.   NATURE BIOTECHNOLOGY

Computational design of a self-assembling symmetrical β-propeller protein

(2014) Arnout R. D. Voet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular architecture of the αβ T cell receptor–CD3 complex

(2014) Michael E. Birnbaum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

(2014) C. A. Diebolder et al.   SCIENCE

NextGen protein design

(2013) Nicholas Sawyer et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Rational design of FRET sensor proteins based on mutually exclusive domain interactions

(2013) Maarten Merkx et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The scoring of poses in protein-protein docking: current capabilities and future directions

(2013) Iain H Moal et al.   BMC BIOINFORMATICS

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

(2013) G. Madhavi Sastry et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

All Repeats Are Not Equal: A Module-Based Approach to Guide Repeat Protein Design

(2013) Nicholas Sawyer et al.   JOURNAL OF MOLECULAR BIOLOGY

Fc-gamma receptor polymorphisms as predictive and prognostic factors in patients receiving oncolytic adenovirus treatment

(2013) Mari Hirvinen et al.   Journal of Translational Medicine

The structure of dual-variable-domain immunoglobulin molecules alone and bound to antigen

(2013) Ivan Correia et al.   mAbs

Novel asymmetrically engineered antibody Fc variant with superior FcγR binding affinity and specificity compared with afucosylated Fc variant

(2013) Futa Mimoto et al.   mAbs

Improving biophysical properties of a bispecific antibody scaffold to aid developability

(2013) Thomas Spreter Von Kreudenstein et al.   mAbs

Structure reveals function of the dual variable domain immunoglobulin (DVD-Ig™) molecule

(2013) Clarissa G. Jakob et al.   mAbs

Crystal structure of a novel asymmetrically engineered Fc variant with improved affinity for FcγRs

(2013) F. Mimoto et al.   MOLECULAR IMMUNOLOGY

Bispecific antibodies with natural architecture produced by co-culture of bacteria expressing two distinct half-antibodies

(2013) Christoph Spiess et al.   NATURE BIOTECHNOLOGY

Crystal Structure of an Anti-Ang2 CrossFab Demonstrates Complete Structural and Functional Integrity of the Variable Domain

(2013) Sebastian Fenn et al.   PLoS One

Bispecific small molecule-antibody conjugate targeting prostate cancer

(2013) C. H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and grafting of a unique peptide-binding site in the Fab framework of monoclonal antibodies

(2013) J. M. Donaldson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Docking, scoring, and affinity prediction in CAPRI

(2013) Marc F. Lensink et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The Structural Basis of Antibody-Antigen Recognition

(2013) Inbal Sela-Culang et al.   Frontiers in Immunology

Physiochemical and Biochemical Factors Influencing the Pharmacokinetics of Antibody Therapeutics

(2012) Daniela Bumbaca et al.   AAPS Journal

Alteration of substrate specificities of thermophilic α/β hydrolases through domain swapping and domain interface optimization

(2012) Xiaoli Zhou et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Designing proteins from simple motifs: opportunities in Top-Down Symmetric Deconstruction

(2012) Michael Blaber et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A Systematic Comparison of Free and Bound Antibodies Reveals Binding-Related Conformational Changes

(2012) I. Sela-Culang et al.   JOURNAL OF IMMUNOLOGY

Trifunctional antibody ertumaxomab: Non-immunological effects on Her2 receptor activity and downstream signaling

(2012) Simone Diermeier-Daucher et al.   mAbs

World Bispecific Antibody Summit, September 27–28, 2011, Boston, MA

(2012) Eugen Dhimolea et al.   mAbs

Dual targeting strategies with bispecific antibodies

(2012) Roland Kontermann   mAbs

Half-life extension of a single-chain diabody by fusion to domain B of staphylococcal protein A

(2012) F. Unverdorben et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Artificial proteins from combinatorial approaches

(2012) Agathe Urvoas et al.   TRENDS IN BIOTECHNOLOGY

Ligand association rates to the inner-variable-domain of a dual-variable-domain immunoglobulin are significantly impacted by linker design

(2011) Enrico L. DiGiammarino et al.   mAbs

Accelerating Protein Docking in ZDOCK Using an Advanced 3D Convolution Library

(2011) Brian G. Pierce et al.   PLoS One

Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies

(2011) W. Schaefer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modular Evolution and the Origins of Symmetry: Reconstruction of a Three-Fold Symmetric Globular Protein

(2011) Aron Broom et al.   STRUCTURE

Effect of FCGR2A and FCGR3A variants on CLL outcome

(2010) D. Dornan et al.   BLOOD

Probing theα-Helical Structural Stability of Stapled p53 Peptides: Molecular Dynamics Simulations and Analysis

(2010) Zuojun Guo et al.   Chemical Biology & Drug Design

Killing of human leukaemia/lymphoma B cells by activated cytotoxic T lymphocytes in the presence of a bispecific monoclonal antibody (αCD3/αCD19)

(2010) I. A. HAAGEN et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Catumaxomab – trifunctional anti-EpCAM antibody used to treat malignant ascites

(2010) Carsten Bokemeyer   EXPERT OPINION ON BIOLOGICAL THERAPY

The trifunctional antibody catumaxomab in treatment of malignant ascites and peritoneal carcinomatosis

(2010) Michael A Ströhlein et al.   Future Oncology

Enhancing Antibody Fc Heterodimer Formation through Electrostatic Steering Effects

(2010) Kannan Gunasekaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical Ramifications of the MHC Family Fc Receptor FcRn

(2010) Derry C. Roopenian et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Neonatal Fc Receptor: From Immunity to Therapeutics

(2010) Timothy T. Kuo et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Daratumumab, a Novel Therapeutic Human CD38 Monoclonal Antibody, Induces Killing of Multiple Myeloma and Other Hematological Tumors

(2010) M. de Weers et al.   JOURNAL OF IMMUNOLOGY

Functional β-propeller lectins by tandem duplications of repetitive units

(2010) Itamar Yadid et al.   PROTEIN ENGINEERING DESIGN & SELECTION

SEEDbodies: fusion proteins based on strand-exchange engineered domain (SEED) CH3 heterodimers in an Fc analogue platform for asymmetric binders or immunofusions and bispecific antibodies†

(2010) Jonathan H. Davis et al.   PROTEIN ENGINEERING DESIGN & SELECTION

The Trifunctional Antibody Ertumaxomab Destroys Tumor Cells That Express Low Levels of Human Epidermal Growth Factor Receptor 2

(2009) M. Jager et al.   CANCER RESEARCH

Monoclonal Antibody Pharmacokinetics and Pharmacodynamics

(2008) W Wang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Optimization of antibody binding to Fc RIIa enhances macrophage phagocytosis of tumor cells

(2008) J. O. Richards et al.   MOLECULAR CANCER THERAPEUTICS

Design of protein function leaps by directed domain interface evolution

(2008) J. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA