NextGen protein design

All Repeats Are Not Equal: A Module-Based Approach to Guide Repeat Protein Design

(2013) Nicholas Sawyer et al.   JOURNAL OF MOLECULAR BIOLOGY

Selection of a high-affinity WW domain against the extracellular region of VEGF receptor isoform-2 from a combinatorial library using CIS display

(2013) S. Patel et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Treatment of Diabetic Macular Edema With a Designed Ankyrin Repeat Protein That Binds Vascular Endothelial Growth Factor: A Phase I/II Study

(2012) Peter A. Campochiaro et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

A modular approach to the design of protein-based smart gels

(2012) Tijana Z. Grove et al.   BIOPOLYMERS

Designed Armadillo Repeat Proteins: Library Generation, Characterization and Selection of Peptide Binders with High Specificity

(2012) Gautham Varadamsetty et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure-Based Rational Design of a Toll-like Receptor 4 (TLR4) Decoy Receptor with High Binding Affinity for a Target Protein

(2012) Jieun Han et al.   PLoS One

Design of a binding scaffold based on variable lymphocyte receptors of jawless vertebrates by module engineering

(2012) S.-C. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phase I and Pharmacokinetic Study of CT-322 (BMS-844203), a Targeted Adnectin Inhibitor of VEGFR-2 Based on a Domain of Human Fibronectin

(2011) A. W. Tolcher et al.   CLINICAL CANCER RESEARCH

68Ga-DOTA-Affibody molecule for in vivo assessment of HER2/neu expression with PET

(2011) Gabriela Kramer-Marek et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Teaching an Old Scaffold New Tricks: Monobodies Constructed Using Alternative Surfaces of the FN3 Scaffold

(2011) Akiko Koide et al.   JOURNAL OF MOLECULAR BIOLOGY

Design of an Optimized Scaffold for Affibody Molecules

(2010) Joachim Feldwisch et al.   JOURNAL OF MOLECULAR BIOLOGY

Toll-Like Receptor 4 Decoy, TOY, Attenuates Gram-Negative Bacterial Sepsis

(2009) Keehoon Jung et al.   PLoS One

High-affinity lamprey VLRA and VLRB monoclonal antibodies

(2009) S. Tasumi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Designed TPR Modules as Novel Anticancer Agents

(2008) Aitziber L. Cortajarena et al.   ACS Chemical Biology

Structure of wild-type Plk-1 kinase domain in complex with a selective DARPin

(2008) Tiago M. Bandeiras et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

DARPins: A new generation of protein therapeutics

(2008) Michael T. Stumpp et al.   DRUG DISCOVERY TODAY

Picomolar Affinity Fibronectin Domains Engineered Utilizing Loop Length Diversity, Recursive Mutagenesis, and Loop Shuffling

(2008) Benjamin J. Hackel et al.   JOURNAL OF MOLECULAR BIOLOGY

A Dominant Conformational Role for Amino Acid Diversity in Minimalist Protein–Protein Interfaces

(2008) Ryan N. Gilbreth et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure and specificity of lamprey monoclonal antibodies

(2008) B. R. Herrin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design of protein function leaps by directed domain interface evolution

(2008) J. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization and Further Stabilization of Designed Ankyrin Repeat Proteins by Combining Molecular Dynamics Simulations and Experiments

(2007) Gianluca Interlandi et al.   JOURNAL OF MOLECULAR BIOLOGY