Itaconic acid underpins hepatocyte lipid metabolism in non-alcoholic fatty liver disease in male mice
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Title
Itaconic acid underpins hepatocyte lipid metabolism in non-alcoholic fatty liver disease in male mice
Authors
Keywords
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Journal
Nature Metabolism
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2023-06-13
DOI
10.1038/s42255-023-00801-2
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Note: Only part of the references are listed.- Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches
- (2022) Martin Guilliams et al. CELL
- Determination of tissue contributions to the circulating lipid pool in cold exposure via systematic assessment of lipid profiles
- (2022) Raghav Jain et al. JOURNAL OF LIPID RESEARCH
- Mycobacterium tuberculosis Induces Irg1 in Murine Macrophages by a Pathway Involving Both TLR-2 and STING/IFNAR Signaling and Requiring Bacterial Phagocytosis
- (2022) Caio C. B. Bomfim et al. Frontiers in Cellular and Infection Microbiology
- Aconitate decarboxylase 1 regulates glucose homeostasis and obesity in mice
- (2022) Ryan A. Frieler et al. Obesity
- Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH
- (2021) Sabine Daemen et al. Cell Reports
- Itaconate Alters Succinate and Coenzyme A Metabolism via Inhibition of Mitochondrial Complex II and Methylmalonyl-CoA Mutase
- (2021) Thekla Cordes et al. Metabolites
- Crown-Like Structures in Breast Adipose Tissue: Early Evidence and Current Issues in Breast Cancer
- (2021) Maret L. Maliniak et al. Cancers
- Hepatic miR-144 drives fumarase activity preventing NRF2 activation during obesity.
- (2021) Valerio Azzimato et al. GASTROENTEROLOGY
- Role of Neutrophils in the Pathogenesis of Nonalcoholic Steatohepatitis
- (2021) Seonghwan Hwang et al. Frontiers in Endocrinology
- Correlation between liver volume and liver weight in a cohort with chronic liver disease: a semiautomated CT-volumetry study
- (2021) Florian Hagen et al. Quantitative Imaging in Medicine and Surgery
- IRG1/Itaconate Activates Nrf2 in Hepatocytes to Protect Against Liver Ischemia–Reperfusion Injury
- (2020) Zhongjie Yi et al. HEPATOLOGY
- Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase
- (2020) Erika M. Palmieri et al. Nature Communications
- Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis
- (2020) Jason S. Seidman et al. IMMUNITY
- Type I Interferon (IFN)-Regulated Activation of Canonical and Non-Canonical Signaling Pathways
- (2020) Candice Mazewski et al. Frontiers in Immunology
- Hepatic stellate cell activation: A source for bioactive lipids
- (2019) Igor O. Shmarakov et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate
- (2019) Wei Qin et al. Nature Chemical Biology
- The Immunomodulatory Potential of the Metabolite Itaconate
- (2019) Alexander Hooftman et al. TRENDS IN IMMUNOLOGY
- Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells
- (2019) Eric H. Ma et al. IMMUNITY
- 4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects
- (2019) Shan-Ting Liao et al. Nature Communications
- Irg1expression in myeloid cells prevents immunopathology duringM. tuberculosisinfection
- (2018) Sharmila Nair et al. JOURNAL OF EXPERIMENTAL MEDICINE
- An inhibitor of oxidative phosphorylation exploits cancer vulnerability
- (2018) Jennifer R. Molina et al. NATURE MEDICINE
- Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors
- (2018) Jonathan M. Weiss et al. JOURNAL OF CLINICAL INVESTIGATION
- Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis
- (2018) Monika Bambouskova et al. NATURE
- Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
- (2018) Evanna L. Mills et al. NATURE
- The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
- (2018) Konstantin Kazankov et al. Nature Reviews Gastroenterology & Hepatology
- Transcriptional Regulation by Nrf2
- (2017) Claudia Tonelli et al. ANTIOXIDANTS & REDOX SIGNALING
- Metabolic phenotype and adipose and liver features in a high-fat Western diet-induced mouse model of obesity-linked NAFLD
- (2016) Yuwen Luo et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- LC-quadrupole/Orbitrap high-resolution mass spectrometry enables stable isotope-resolved simultaneous quantification and 13C-isotopic labeling of acyl-coenzyme A thioesters
- (2016) Alexander J. Frey et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Carnitine transport and fatty acid oxidation
- (2016) Nicola Longo et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation
- (2016) Vicky Lampropoulou et al. Cell Metabolism
- Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells of murine macrophage lineage
- (2016) Beáta Németh et al. FASEB JOURNAL
- Nonalcoholic Steatohepatitis Is the Second Leading Etiology of Liver Disease Among Adults Awaiting Liver Transplantation in the United States
- (2015) Robert J. Wong et al. GASTROENTEROLOGY
- Mouse Models of Diet-Induced Nonalcoholic Steatohepatitis Reproduce the Heterogeneity of the Human Disease
- (2015) Mariana Verdelho Machado et al. PLoS One
- Immune responsive gene 1, a novel oncogene, increases the growth and tumorigenicity of glioma
- (2014) JUN PAN et al. ONCOLOGY REPORTS
- Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome
- (2014) Hannele Yki-Järvinen Lancet Diabetes & Endocrinology
- Immunoresponsive Gene 1 Augments Bactericidal Activity of Macrophage-Lineage Cells by Regulating β-Oxidation-Dependent Mitochondrial ROS Production
- (2013) Christopher J. Hall et al. Cell Metabolism
- The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease
- (2013) Victoria L. Gadd et al. HEPATOLOGY
- Hepatic Crown-Like Structure: A Unique Histological Feature in Non-Alcoholic Steatohepatitis in Mice and Humans
- (2013) Michiko Itoh et al. PLoS One
- Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production
- (2013) A. Michelucci et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis
- (2012) Anne Leroux et al. JOURNAL OF HEPATOLOGY
- Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition
- (2011) Michael Charlton et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Itaconic Acid Is a Mammalian Metabolite Induced during Macrophage Activation
- (2011) Cheryl L. Strelko et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Dynamic, M2-Like Remodeling Phenotypes of CD11c+ Adipose Tissue Macrophages During High-Fat Diet-Induced Obesity in Mice
- (2010) M. E. Shaul et al. DIABETES
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