Temozolomide, Simvastatin and Acetylshikonin Combination Induces Mitochondrial-Dependent Apoptosis in GBM Cells, Which Is Regulated by Autophagy

Wnt and PI3K/Akt/mTOR Survival Pathways as Therapeutic Targets in Glioblastoma

(2022) Amir Barzegar Behrooz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Acetylshikonin induces autophagy‐dependent apoptosis through the key LKB1‐AMPK and PI3K/Akt‐regulated mTOR signalling pathways in HL‐60 cells

(2022) Meng‐Di Wu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Acetylshikonin, A Novel CYP2J2 Inhibitor, Induces Apoptosis in RCC Cells via FOXO3 Activation and ROS Elevation

(2022) Heui Min Lim et al.   Oxidative Medicine and Cellular Longevity

Epidemiology of Glioblastoma Multiforme–Literature Review

(2022) Szymon Grochans et al.   Cancers

Effect of Statins on Lung Cancer Molecular Pathways: A Possible Therapeutic Role

(2022) Gianmarco Marcianò et al.   Pharmaceuticals

Shikonin derivatives cause apoptosis and cell cycle arrest in human chondrosarcoma cells via death receptors and MAPK regulation

(2022) Birgit Lohberger et al.   BMC CANCER

The mevalonate pathway in breast cancer biology

(2022) Andy Göbel et al.   CANCER LETTERS

PERK/EIF2AK3 integrates endoplasmic reticulum stress-induced apoptosis, oxidative stress and autophagy responses in immortalised retinal pigment epithelial cells

(2022) Neil Saptarshi et al.   Scientific Reports

Inhibition of Mitochondrial Biosynthesis using a “Right‐Side‐Out” Membrane‐Camouflaged Micelle to Facilitate the Therapeutic Effects of Shikonin on Triple‐Negative Breast Cancer

(2022) Jianqing Peng et al.   Advanced Healthcare Materials

Obstacles to Glioblastoma Treatment Two Decades after Temozolomide

(2022) João Victor Roza Cruz et al.   Cancers

Immunology Meets Bioengineering: Improving the Effectiveness of Glioblastoma Immunotherapy

(2022) Zahra Fekrirad et al.   Cancers

Epigenetic regulation of autophagy in gastrointestinal cancers

(2022) Saeid Ghavami et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The role of Shikonin in improving 5-aminolevulinic acid-based photodynamic therapy and chemotherapy on glioblastoma stem cells

(2022) Maxim Werner et al.   Photodiagnosis and Photodynamic Therapy

Differential impact of doxorubicin dose on cell death and autophagy pathways during acute cardiotoxicity

(2022) Philip Kawalec et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The Effects of Swine Coronaviruses on ER Stress, Autophagy, Apoptosis, and Alterations in Cell Morphology

(2022) Ya-Mei Chen et al.   Pathogens

Autophagy promotes cell survival by maintaining NAD levels

(2022) Tetsushi Kataura et al.   DEVELOPMENTAL CELL

Novel shikonin derivatives suppress cell proliferation, migration and induce apoptosis in human triple-negative breast cancer cells via regulating PDK1/PDHC axis

(2022) Qingqing Chen et al.   LIFE SCIENCES

Acetylshikonin induces apoptosis of human osteosarcoma U2OS cells by triggering ROS-dependent multiple signal pathways

(2022) Hyo Sun Cha et al.   TOXICOLOGY IN VITRO

New Visions on Natural Products and Cancer Therapy: Autophagy and Related Regulatory Pathways

(2022) Alma Martelli et al.   Cancers

Effect of casein kinase 1α inhibition on autophagy flux and the AKT/phospho-β-catenin (S552) axis in HCT116, a RAS-mutated colorectal cancer cell line

(2021) Hamid Behrouj et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Chloroquine: Autophagy inhibitor, antimalarial, bitter taste receptor agonist in fight against COVID-19, a reality check?

(2021) Pawan Sharma et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Casein Kinase-1-Alpha Inhibitor (D4476) Sensitizes Microsatellite Instable Colorectal Cancer Cells to 5-Fluorouracil via Authophagy Flux Inhibition

(2021) Morvarid Siri et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Statins: a repurposed drug to fight cancer

(2021) Wen Jiang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Inhibition of Autophagy Flux Promotes Secretion of Chondroitin Sulfate Proteoglycans in Primary Rat Astrocytes

(2021) Javad Alizadeh et al.   MOLECULAR NEUROBIOLOGY

Autophagy, Apoptosis, the Unfolded Protein Response, and Lung Function in Idiopathic Pulmonary Fibrosis

(2021) Pawan Sharma et al.   Cells

Targeted regulation of autophagy using nanoparticles: New insight into cancer therapy

(2021) Mahshid Deldar Abad Paskeh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Liposomal simvastatin sensitizes C26 murine colon carcinoma to the antitumor effects of liposomal 5‐fluorouracil in vivo

(2020) Lavinia Luput et al.   CANCER SCIENCE

Investigating Programmed Cell Death and Tumor Invasion in a Three-Dimensional (3D) Microfluidic Model of Glioblastoma

(2020) Ehsan Samiei et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

BNIP3L/Nix-induced mitochondrial fission, mitophagy, and impaired myocyte glucose uptake are abrogated by PRKA/PKA phosphorylation

(2020) Simone C. da Silva Rosa et al.   Autophagy

Simvastatin Induces Unfolded Protein Response and Enhances Temozolomide-Induced Cell Death in Glioblastoma Cells

(2020) Sanaz Dastghaib et al.   Cells

Pleiotropic effects of statins: A focus on cancer

(2020) Mazaher Ahmadi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Shikonin induces tumor apoptosis in glioma cells via endoplasmic reticulum stress, and Bax/Bak mediated mitochondrial outer membrane permeability

(2020) Xiaoqin Ma et al.   JOURNAL OF ETHNOPHARMACOLOGY

Targeting cholesterol metabolism in glioblastoma: a new therapeutic approach in cancer therapy

(2019) Leila Pirmoradi et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Simvastatin Induces Apoptosis in Medulloblastoma Brain Tumor Cells via Mevalonate Cascade Prenylation Substrates

(2019) Kimia Sheikholeslami et al.   Cancers

Simvastatin Increases Temozolomide‐induced Cell Death by Targeting the Fusion of Autophagosomes and Lysosomes

(2019) Shahla Shojaei et al.   FEBS Journal

Mechanisms of simvastatin myotoxicity: The role of autophagy flux inhibition

(2019) Arya Emami et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Acetylshikonin induces apoptosis of human leukemia cell line K562 by inducing S phase cell cycle arrest, modulating ROS accumulation, depleting Bcr-Abl and blocking NF-κB signaling

(2019) Gangping Hao et al.   BIOMEDICINE & PHARMACOTHERAPY

Autophagy modulates transforming growth factor beta 1 induced epithelial to mesenchymal transition in non-small cell lung cancer cells

(2018) Javad Alizadeh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Recent Advances on Glioblastoma Multiforme and Nano-drug Carriers: A Review

(2018) Wang Liao et al.   CURRENT MEDICINAL CHEMISTRY

MDR reversal and pro-apoptotic effects of statins and statins combined with flavonoids in colon cancer cells

(2018) Anna Palko-Łabuz et al.   BIOMEDICINE & PHARMACOTHERAPY

Thioridazine inhibits autophagy and sensitizes glioblastoma cells to temozolomide

(2018) Tor‐Christian Johannessen et al.   INTERNATIONAL JOURNAL OF CANCER

Statins: a new approach to combat temozolomide chemoresistance in glioblastoma

(2018) Shahla Shojaei et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Dual treatment with shikonin and temozolomide reduces glioblastoma tumor growth, migration and glial-to-mesenchymal transition

(2017) Diana Matias et al.   CELLULAR ONCOLOGY

Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells

(2017) Javad Alizadeh et al.   Scientific Reports

Acetylshikonin inhibits growth of oral squamous cell carcinoma by inducing apoptosis

(2016) Da Jeong Kim et al.   ARCHIVES OF ORAL BIOLOGY

Perturbation of redox balance after thioredoxin reductase deficiency interrupts autophagy-lysosomal degradation pathway and enhances cell death in nutritionally stressed SH-SY5Y cells

(2016) Pandian Nagakannan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Correction: Shikonin Suppresses NLRP3 and AIM2 Inflammasomes by Direct Inhibition of Caspase-1

(2016) Jernej Zorman et al.   PLoS One

Inhibition of autophagy inhibits the conversion of cardiac fibroblasts to cardiac myofibroblasts

(2016) Shivika S. Gupta et al.   Oncotarget

Photodynamic N-TiO2 Nanoparticle Treatment Induces Controlled ROS-mediated Autophagy and Terminal Differentiation of Leukemia Cells

(2016) Mohammad Amin Moosavi et al.   Scientific Reports

Shikonin Induced Necroptosis via Reactive Oxygen Species in the T-47D Breast Cancer Cell Line

(2015) Zahra Shahsavari et al.   Asian Pacific Journal of Cancer Prevention

Shikonin and its derivatives inhibit the epidermal growth factor receptor signaling and synergistically kill glioblastoma cells in combination with erlotinib

(2015) Qiaoli Zhao et al.   INTERNATIONAL JOURNAL OF CANCER

Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response

(2015) Behzad Yeganeh   WORLD JOURNAL OF GASTROENTEROLOGY

Airway mesenchymal cell death by mevalonate cascade inhibition: Integration of autophagy, unfolded protein response and apoptosis focusing on Bcl2 family proteins

(2014) Saeid Ghavami et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Statin use and survival following glioblastoma multiforme

(2014) David Gaist et al.   Cancer Epidemiology

Acetylshikonin induces apoptosis of hepatitis B virus X protein-expressing human hepatocellular carcinoma cells via endoplasmic reticulum stress

(2014) Jeong Moon et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Enhanced apoptosis by pemetrexed and simvastatin in malignant mesothelioma and lung cancer cells by reactive oxygen species-dependent mitochondrial dysfunction and Bim induction

(2014) KI-EUN HWANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease

(2014) Behzad Yeganeh et al.   PHARMACOLOGY & THERAPEUTICS

Bcl-2 maintains the mitochondrial membrane potential, but fails to affect production of reactive oxygen species and endoplasmic reticulum stress, in sodium palmitate-induced β-cell death

(2014) Xuan Wang et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

Human-Gyrovirus-Apoptin Triggers Mitochondrial Death Pathway—Nur77 is Required for Apoptosis Triggering

(2014) Wiem Chaabane et al.   NEOPLASIA

Crosstalk between apoptosis, necrosis and autophagy

(2013) Vassiliki Nikoletopoulou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Synergistic induction of apoptosis by sulindac and simvastatin in A549 human lung cancer cells via reactive oxygen species-dependent mitochondrial dysfunction

(2013) KI-EUN HWANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Anticancer Agent Shikonin Is an Incompetent Inducer of Cancer Drug Resistance

(2013) Hao Wu et al.   PLoS One

Autophagy regulates trans fatty acid-mediated apoptosis in primary cardiac myofibroblasts

(2012) Saeid Ghavami et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Statin Use and Reduced Cancer-Related Mortality

(2012) Sune F. Nielsen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Apoptosis, autophagy and ER stress in mevalonate cascade inhibition-induced cell death of human atrial fibroblasts

(2012) S Ghavami et al.   Cell Death & Disease

The strategy for enhancing temozolomide against malignant glioma

(2012) Mitsutoshi Nakada et al.   Frontiers in Oncology

Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle

(2011) Saeid Ghavami et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Resveratrol enhances the therapeutic effect of temozolomide against malignant glioma in vitro and in vivo by inhibiting autophagy

(2011) Chien-Ju Lin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mevalonate Cascade Regulation of Airway Mesenchymal Cell Autophagy and Apoptosis: A Dual Role for p53

(2011) Saeid Ghavami et al.   PLoS One

Statin-triggered cell death in primary human lung mesenchymal cells involves p53-PUMA and release of Smac and Omi but not cytochrome c

(2010) Saeid Ghavami et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial Complex II Prevents Hypoxic but Not Calcium- and Proapoptotic Bcl-2 Protein-induced Mitochondrial Membrane Potential Loss

(2010) Brian J. Hawkins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3

(2009) Saeid Ghavami et al.   CELL RESEARCH

In vitro and in vivo antitumor effects of acetylshikonin isolated from Arnebia euchroma (Royle) Johnst (Ruanzicao) cell suspension cultures

(2009) Wenbi Xiong et al.   Chinese Medicine

Brevinin-2R1 semi-selectively kills cancer cells by a distinct mechanism, which involves the lysosomal-mitochondrial death pathway

(2008) Saeid Ghavami et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Association Between Statins and Cancer Incidence in a Veterans Population

(2008) W. R. Farwell et al.   JNCI-Journal of the National Cancer Institute