Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle

Lovastatin inhibits proliferation of anaplastic thyroid cancer cells through up-regulation of p27 by interfering with the Rho/ROCK-mediated pathway

(2011) Wen-Bin Zhong et al.   BIOCHEMICAL PHARMACOLOGY

Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death

(2011) W Gao et al.   CELL DEATH AND DIFFERENTIATION

Role of Rho GTPases and their regulators in cancer progression

(2011) Rajamani Rathinam   Frontiers in Bioscience-Landmark

Remodeling in asthma

(2011) Saleh Al-Muhsen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance

(2011) Monika Mortensen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rad is a p53 direct transcriptional target that inhibits cell migration and is frequently silenced in lung carcinoma cells

(2011) Bo-Yuan Hsiao et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Bisphosphonates Induce Autophagy by Depleting Geranylgeranyl Diphosphate

(2011) B. M. Wasko et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

PERK Integrates Autophagy and Oxidative Stress Responses To Promote Survival during Extracellular Matrix Detachment

(2011) A. Avivar-Valderas et al.   MOLECULAR AND CELLULAR BIOLOGY

Uncoupling p53 Functions in Radiation-Induced Intestinal Damage via PUMA and p21

(2011) B. J. Leibowitz et al.   MOLECULAR CANCER RESEARCH

Phosphorylation of Tip60 by GSK-3 Determines the Induction of PUMA and Apoptosis by p53

(2011) Céline Charvet et al.   MOLECULAR CELL

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

Mevalonate Cascade Regulation of Airway Mesenchymal Cell Autophagy and Apoptosis: A Dual Role for p53

(2011) Saeid Ghavami et al.   PLoS One

Simvastatin induces apoptosis by a Rho-dependent mechanism in cultured cardiac fibroblasts and myofibroblasts

(2011) Miguel Copaja et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The Mevalonate Cascade as a Target to Suppress Extracellular Matrix Synthesis by Human Airway Smooth Muscle

(2010) Dedmer Schaafsma et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Role of Transforming Growth Factor–β in Airway Remodeling in Asthma

(2010) Rabih Halwani et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Statin-triggered cell death in primary human lung mesenchymal cells involves p53-PUMA and release of Smac and Omi but not cytochrome c

(2010) Saeid Ghavami et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

 -Dystroglycan binds caveolin-1 in smooth muscle: a functional role in caveolae distribution and Ca2+ release

(2010) P. Sharma et al.   JOURNAL OF CELL SCIENCE

A Novel Geranylgeranyl Transferase Inhibitor in Combination with Lovastatin Inhibits Proliferation and Induces Autophagy in STS-26T MPNST Cells

(2010) K. M. Sane et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3

(2009) Saeid Ghavami et al.   CELL RESEARCH

Monomeric G-proteins as signal transducers in airway physiology and pathophysiology

(2008) Dedmer Schaafsma et al.   CELLULAR SIGNALLING

Brevinin-2R1 semi-selectively kills cancer cells by a distinct mechanism, which involves the lysosomal-mitochondrial death pathway

(2008) Saeid Ghavami et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE