The Human Extracellular Matrix Diseasome Reveals Genotype–Phenotype Associations with Clinical Implications for Age-Related Diseases

Matrisome changes in Parkinson’s disease

(2022) Margaret Downs et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

The Future of Precision Medicine to Predict Outcomes and Control Tissue Remodeling in Inflammatory Bowel Disease

(2022) Christopher A. Lamb et al.   GASTROENTEROLOGY

The Role of the Extracellular Matrix in Neural Progenitor Cell Proliferation and Cortical Folding During Human Neocortex Development

(2022) Katherine R. Long et al.   Frontiers in Cellular Neuroscience

The Relationship Between Generalised Joint Hypermobility and Autism Spectrum Disorder in Adults: A Large, Cross-Sectional, Case Control Comparison

(2022) Martin R. Glans et al.   Frontiers in Psychiatry

Targeting the cytoskeleton and extracellular matrix in cardiovascular disease drug discovery

(2022) Bohdan B. Khomtchouk et al.   Expert Opinion on Drug Discovery

Plasminogen activating inhibitor‐1 promotes angiogenesis in cutaneous angiosarcomas

(2022) Kentaro Ohuchi et al.   EXPERIMENTAL DERMATOLOGY

Towards Precision Medicine for Osteoarthritis: Focus on the Synovial Fluid Proteome

(2022) Lorenzo Moretti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular matrix profiles determine risk and prognosis of the squamous cell carcinoma subtype of non-small cell lung carcinoma

(2022) Amelia L. Parker et al.   Genome Medicine

Changes in the Brain Extracellular Matrix Composition in schizophrenia: A Pathophysiological Dysregulation and a Potential Therapeutic Target

(2021) Daniela Rodrigues-Amorim et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Assessing rare diseases prevalence using literature quantification

(2021) Jason Shourick et al.   Orphanet Journal of Rare Diseases

Type 1 Diabetes and the HLA Region: Genetic Association Besides Classical HLA Class II Genes

(2021) Jana Sticht et al.   Frontiers in Genetics

Molecular Signature of Extracellular Matrix Pathology in Schizophrenia

(2020) Harry Pantazopoulos et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Tumor organoid models in precision medicine and investigating cancer-stromal interactions

(2020) Ren Xu et al.   PHARMACOLOGY & THERAPEUTICS

The Roles of Tenascins in Cardiovascular, Inflammatory, and Heritable Connective Tissue Diseases

(2020) Ken-ichi Matsumoto et al.   Frontiers in Immunology

The Relationship between Autism and Ehlers-Danlos Syndromes/Hypermobility Spectrum Disorders

(2020) Emily L. Casanova et al.   Journal of Personalized Medicine

The extracellular matrix as a multitasking player in disease

(2019) Achilleas D. Theocharis et al.   FEBS Journal

Evaluation of Platelet Parameters in Children with Autism Spectrum Disorder: Elongated Collagen‐Adenosine Diphosphate and Collagen‐Epinephrine Closure Times

(2019) Nurdan Coban et al.   Autism Research

Transcriptome profiling revealed multiple genes and ECM-receptor interaction pathways that may be associated with breast cancer

(2019) Yulong Bao et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Exploring the extracellular matrix in health and disease using proteomics

(2019) Isra N. Taha et al.   Essays in Biochemistry

The Monarch Initiative in 2019: an integrative data and analytic platform connecting phenotypes to genotypes across species

(2019) Kent A Shefchek et al.   NUCLEIC ACIDS RESEARCH

Collagens and elastin genetic variations and their potential role in aging-related diseases and longevity in humans

(2019) Roman Romero-Ortuno et al.   EXPERIMENTAL GERONTOLOGY

The Matrisome during Aging and Longevity: A Systems-Level Approach toward Defining Matreotypes Promoting Healthy Aging

(2019) Collin Yvès Ewald   GERONTOLOGY

Higher Collagen VI Formation Is Associated With All-Cause Mortality in Patients With Type 2 Diabetes and Microalbuminuria

(2018) Daniel G.K. Rasmussen et al.   DIABETES CARE

Collagen VI in healthy and diseased nervous system

(2018) Ilaria Gregorio et al.   Disease Models & Mechanisms

From Structure to Phenotype: Impact of Collagen Alterations on Human Health

(2018) Lavinia Arseni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular matrix: The driving force of mammalian diseases

(2018) Renato V. Iozzo et al.   MATRIX BIOLOGY

Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials

(2018) Marsha C. Lampi et al.   Science Translational Medicine

Pathway networks generated from human disease phenome

(2018) Ann G. Cirincione et al.   BMC Medical Genomics

Genome-wide association studies of brain imaging phenotypes in UK Biobank

(2018) Lloyd T. Elliott et al.   NATURE

X-linked Alport syndrome: pathogenic variant features and further auditory genotype-phenotype correlations in males

(2018) Xiao Zhang et al.   Orphanet Journal of Rare Diseases

Phenome-wide association studies: a new method for functional genomics in humans

(2017) Dan M. Roden   JOURNAL OF PHYSIOLOGY-LONDON

Extracellular matrix proteomics in schizophrenia and Alzheimer’s disease

(2016) Manveen K. Sethi et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Phenome-Wide Association Studies as a Tool to Advance Precision Medicine

(2016) Joshua C. Denny et al.   Annual Review of Genomics and Human Genetics

The extracellular matrix: Tools and insights for the “omics” era

(2016) Alexandra Naba et al.   MATRIX BIOLOGY

Glycan susceptibility factors in autism spectrum disorders

(2016) Chrissa A. Dwyer et al.   MOLECULAR ASPECTS OF MEDICINE

Unravelling the human genome–phenome relationship using phenome-wide association studies

(2016) William S. Bush et al.   NATURE REVIEWS GENETICS

Opportunities for drug repositioning from phenome-wide association studies

(2015) Majid Rastegar-Mojarad et al.   NATURE BIOTECHNOLOGY

The European Genome-phenome Archive of human data consented for biomedical research

(2015) Ilkka Lappalainen et al.   NATURE GENETICS

Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity

(2014) Collin Y. Ewald et al.   NATURE

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mutations in the collagen XII gene define a new form of extracellular matrix-related myopathy

(2013) D. Hicks et al.   HUMAN MOLECULAR GENETICS

Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data

(2013) Joshua C Denny et al.   NATURE BIOTECHNOLOGY

The Intersection Between Aging and Cardiovascular Disease

(2012) Brian J. North et al.   CIRCULATION RESEARCH

Extracellular matrix abnormalities in schizophrenia

(2011) Sabina Berretta   NEUROPHARMACOLOGY

Overview of the Matrisome--An Inventory of Extracellular Matrix Constituents and Functions

(2011) R. O. Hynes et al.   Cold Spring Harbor Perspectives in Biology

Extracellular Matrix-Glial Abnormalities in the Amygdala and Entorhinal Cortex of Subjects Diagnosed With Schizophrenia

(2010) Harry Pantazopoulos et al.   ARCHIVES OF GENERAL PSYCHIATRY

Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI

(2008) T. Khan et al.   MOLECULAR AND CELLULAR BIOLOGY

Clinical research for rare disease: Opportunities, challenges, and solutions

(2008) Robert C. Griggs et al.   MOLECULAR GENETICS AND METABOLISM