Article
Nutrition & Dietetics
Hexin Su, Yacong Bo, Xiaoan Zhang, Junxi Zhang, Zhan Gao, Zengli Yu
Summary: This study found that higher dietary folate intake was associated with lower all-cause and cardiovascular mortality among individuals with type 2 diabetes. The association was observed in both men and women, with stronger associations seen in men. Increasing folate intake in the diet may reduce mortality risk in US adults with type 2 diabetes.
FRONTIERS IN NUTRITION
(2022)
Article
Endocrinology & Metabolism
Chang Liu, Zhong Xin, Lin Hua
Summary: This retrospective study analyzed data from 1,208 individuals with diabetes and found that FT3 level is associated with all-cause mortality, cardio-cerebrovascular mortality, and cardiovascular mortality, especially among individuals over the age of 60, indicating that FT3 is an independent predictor of all-cause death in diabetic subjects.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Health Care Sciences & Services
Yixuan Zhu, Chuan Liu, Xiaoming Xu, Xiaoyan Ma, Jiacheng Liu, Zhiyi Zhang, Fuchao Li, Danny Ka-Ho Wong, Zhiwen Fan, Chao Wu, Xiaolong Qi, Jie Li
Summary: Diabetes mellitus (DM) is associated with an increased risk of all-cause and cause-specific mortality in patients with different forms of metabolic-dysfunction-associated fatty liver disease (MAFLD), especially in young overweight and obese individuals.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Nutrition & Dietetics
Xuena Zhang, Yunjing Ou, Lin Li, Zhenzhen Wan, Qi Lu, Tingting Geng, Yujie Liu, Zixin Qiu, Kai Zhu, Kun Yang, An Pan, Gang Liu
Summary: Higher nut consumption is associated with lower all-cause mortality among individuals with type 2 diabetes (T2D). The substitution of nuts for certain foods is also linked to reduced mortality risk. The study suggests that nut consumption may have a beneficial effect in preventing premature death among individuals with T2D.
JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Jiao Wang, Yunliang Tang, Ying Liu, Wei Cai, Jixiong Xu
Summary: This study found a significant correlation between serum methylmalonic acid (MMA) levels and all-cause and cause-specific deaths in individuals with diabetes. Higher serum MMA levels were associated with higher all-cause, cardiovascular disease (CVD), and cancer mortality rates.
FRONTIERS IN NUTRITION
(2022)
Article
Endocrinology & Metabolism
Lin Zhou, Jianing Zhang, Dan Zhang, Ye Yu, Mengqi Jiang, Huiying Liu, Jiatong Li, Minghui Li, Zhuo Zhang, Lianying Guo
Summary: This study found that high-level co-exposure to multiple vitamins can significantly reduce the risk of all-cause mortality in patients with diabetes. Differences in gender, age, and race also affect the impact of vitamins on mortality risk.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Regina Prigge, Sarah H. Wild, Caroline A. Jackson
Summary: This study investigated the mortality risks among participants with diabetes, depression, or both in a large cohort study in the UK. The results showed that individuals with both depression and diabetes had the highest risk of all-cause mortality, particularly from cancer and non-circulatory diseases.
Article
Nutrition & Dietetics
Shamima Akter, Tetsuya Mizoue, Akiko Nanri, Atsushi Goto, Mitsuhiko Noda, Norie Sawada, Taiki Yamaji, Motoki Iwasaki, Manami Inoue, Shoichiro Tsugane
Summary: The study found a U-shaped association between low-carbohydrate diet (LCD) score and total mortality among Asians, with high animal protein and fat in LCD associated with higher mortality risk. Conversely, a LCD high in plant-based sources of protein and fat was associated with a lower risk of total and cardiovascular mortality.
CLINICAL NUTRITION
(2021)
Article
Cardiac & Cardiovascular Systems
Li-Da Wu, Peng Chu, Chao-Hua Kong, Yi Shi, Ming-Hui Zhu, Yi-Yuan Xia, Zheng Li, Jun-Xia Zhang, Shao-Liang Chen
Summary: This study aims to investigate the association of estimated pulse wave velocity (ePWV) with all-cause and cardiovascular mortality in patients with diabetes. The results showed that there was a close association between the increment of ePWV and increased risks of all-cause and cardiovascular mortality in patients with diabetes. Therefore, ePWV is of great significance in assessing the mortality risk in patients with diabetes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Yun Shen, Lei Chen, Jian Zhou, Chunfang Wang, Fei Gao, Wei Zhu, Gang Hu, Xiaojing Ma, Han Xia, Yuqian Bao
Summary: This study investigated the association between osteocalcin and mortality in patients with type 2 diabetes using long-term longitudinal data. The results showed a U-shaped association between baseline osteocalcin and mortality, with patients having lower levels of osteocalcin having higher risks of all-cause and cardiovascular mortality during follow-up.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Juan Xu, Yimeng Sun, Dandan Gong, Yu Fan
Summary: This meta-analysis study found that preexisting diabetes has a significant impact on cardiovascular and all-cause mortality in patients with atrial fibrillation. Patients with diabetes have a higher risk of death.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ping Zhu, Guojuan Lao, Chuping Chen, Lihui Luo, Jing Gu, Jianmin Ran
Summary: This study found a U-shaped relationship between thyroid-stimulating hormone (TSH) levels within the normal range and cardiovascular disease (CVD) and all-cause mortality in euthyroid adults with diabetes. Both low-normal and high-normal TSH levels were associated with increased mortality risk. The association was more pronounced in younger patients with diabetes.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Yuxin Fan, Li Ding, Yalan Zhang, Hua Shu, Qing He, Jingqiu Cui, Gang Hu, Ming Liu
Summary: There is an association between vitamin D status and all-cause mortality among patients with type 2 diabetes. Very low or high concentrations of vitamin D may increase the risk of all-cause mortality in these patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Weiqi Li, Jiakuan Peng, Qianhui Shang, Dan Yang, Hang Zhao, Hao Xu
Summary: This study found that moderate/severe periodontitis is associated with increased all-cause and cardiovascular disease-related mortality in adults with diabetes. Periodontitis may represent a marker for residual risk.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Endocrinology & Metabolism
Jingyi Lu, Chunfang Wang, Jinghao Cai, Yun Shen, Lei Chen, Lei Zhang, Wei Lu, Wei Zhu, Gang Hu, Tian Xia, Jian Zhou
Summary: The relationship between HbA1c and all-cause mortality among patients with type 2 diabetes varies depending on the degree of glycemic variability. In patients with high glycemic variability, HbA1c may not be a robust marker of mortality, suggesting the need for new metrics for better diabetes management in these individuals.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Transplantation
Jennifer B. Green, Amy K. Mottl, George Bakris, Hiddo J. L. Heerspink, Johannes F. E. Mann, Janet B. McGill, Masaomi Nangaku, Peter Rossing, Charlie Scott, Alain Gay, Rajiv Agarwal
Summary: This study aims to investigate the efficacy of dual therapy with finerenone and an SGLT2i in reducing chronic kidney disease and type 2 diabetes. The results will provide important insights for improving treatment methods for kidney disease and cardiovascular risks.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Endocrinology & Metabolism
Peter Rossing, Rajiv Agarwal, Stefan D. Anker, Gerasimos Filippatos, Bertram Pitt, Luis M. Ruilope, Vivian Fonseca, Guillermo E. Umpierrez, Maria Luiza Caramori, Amer Joseph, Marc Lambelet, Robert Lawatscheck, George L. Bakris
Summary: This study investigated the effect of GLP-1RA use on the outcomes of patients with CKD and T2D treated with finerenone. The results showed that the use of GLP-1RA did not affect the cardiorenal benefits of finerenone.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Jens Christian Laursen, Ida Kirstine Bull Rasmussen, Emilie Hein Zobel, Philip Hasbak, Lene Holmvang, Christian Stevns Hansen, Bernt Johan von Scholten, Marie Frimodt-Moller, Peter Rossing, Tine Willum Hansen, Andreas Kjaer, Rasmus Sejersten Ripa
Summary: Cardiac angiogenesis assessed by Ga-68-RGD PET was similar in type 2 diabetes and non-diabetic controls, and was not associated with kidney function or other risk factors.
Article
Medicine, General & Internal
Sankar D. Navaneethan, Sophia Zoungas, M. Luiza Caramori, Juliana C. N. Chan, Hiddo J. L. Heerspink, Clint Hurst, Adrian Liew, Erin D. Michos, Wasiu A. Olowu, Tami Sadusky, Nikhil Tandon, Katherine R. Tuttle, Christoph Wanner, Katy G. Wilkens, Jonathan C. Craig, David J. Tunnicliffe, Marcello Tonelli, Michael Cheung, Amy Earley, Peter Rossing, Ian H. de Boer, Kamlesh Khunti
Summary: The KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease is an update of the 2020 guideline. The guideline was updated based on reviewing new evidence and using the GRADE approach to assess evidence and develop consensus practice points. The recommendations were updated in the areas of comprehensive care and glucose-lowering therapies, while recommendations in the areas of glycemic monitoring, lifestyle interventions, and management approaches remained unchanged.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Transplantation
Peter Rossing, Florian M. M. Baeres, George Bakris, Heidrun Bosch-Traberg, Mette Gislum, Stephen C. L. Gough, Thomas Idorn, Jack Lawson, Kenneth W. Mahaffey, Johannes F. E. Mann, Henriette Mersebach, Vlado Perkovic, Katherine Tuttle, Richard Pratley, FLOW Steering Comm, FLOW Trial Investigators
Summary: This study aims to investigate the effects of semaglutide on kidney outcomes in patients with chronic kidney disease (CKD) and type 2 diabetes (T2D). The participants were found to be mostly at high risk for CKD progression. The study is expected to be completed in late 2024.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Endocrinology & Metabolism
Suvanjaa Sivalingam, Victor Soendergaard Wasehuus, Viktor Rotbain Curovic, Martin Baek Blond, Tine W. Hansen, Frederik Persson, Peter Rossing
Summary: The combination of semaglutide and empagliflozin did not lead to changes in UACR, GFR, blood pressure, body weight, or plasma renin levels in individuals with T2D and albuminuria. However, semaglutide improved glycaemic control and plasma aldosterone levels compared to placebo.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Viktor Rotbain Curovic, Morten B. Houlind, Marjolein Y. A. M. Kroonen, Niels Jongs, Emilie H. Zobel, Tine W. Hansen, Juliette Tavenier, Jesper Eugen-Olsen, Gozewijn D. Laverman, Adriaan Kooy, Frederik Persson, Peter Rossing, Hiddo J. L. Heerspink
Summary: The effect of four different drug classes on suPAR levels in people with type 1 and type 2 diabetes was evaluated. The study showed no overall effect of the drugs on suPAR levels, but individualized treatment significantly reduced suPAR levels.
DIABETES OBESITY & METABOLISM
(2023)
Letter
Endocrinology & Metabolism
Jens Christian Laursen, Viktor Rotbain Curovic, Marjolein Y. A. M. Kroonen, Niels Jongs, Emilie H. Zobel, Tine W. Hansen, Marie Frimodt-Moller, Gozewijn D. Laverman, Adriaan Kooy, Frederik Persson, Hiddo J. L. Heerspink, Christian Stevns Hansen, Peter Rossing
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Hiddo J. L. Heerspink, Andreas L. Birkenfeld, David Z. I. Cherney, Helen M. Colhoun, Linong Ji, Chantal Mathieu, Per-Henrik Groop, Richard E. Pratley, Sylvia E. Rosas, Peter Rossing, Jay S. Skyler, Katherine R. Tuttle, Robert Lawatscheck, Charlie Scott, Robert Edfors, Markus F. Scheerer, Peter Kolkhof, Janet B. McGill
Summary: This study aims to evaluate the efficacy and safety of Finerenone in type 1 diabetes and chronic kidney disease (CKD). Finerenone could potentially become the first registered treatment for CKD associated with type 1 diabetes in almost 30 years.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Zeinab Schafer, Andreas Mathisen, Trine Rolighed Thomsen, Peter Rossing, Klaus Kirketerp-Moller
Summary: This study conducted a cohort analysis on 309,116 patients with type 2 diabetes and found that GLP-1 agonist treatment significantly reduces the risk of lower extremity amputations, particularly among middle-income patients.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Review
Endocrinology & Metabolism
Vikas S. Sridhar, Christine P. Limonte, Per-Henrik Groop, Hiddo J. L. Heerspink, Richard E. Pratley, Peter Rossing, Jay S. Skyler, David Z. I. Cherney
Summary: The current management of CKD in type 1 diabetes focuses on blood sugar control, inhibiting the renin-angiotensin system and optimizing risk factors. However, individuals with type 1 diabetes and CKD still face elevated risks for kidney and cardiovascular events. Novel therapies used in type 2 diabetes, such as sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide 1 receptor agonists, have shown potential kidney and heart protection. Applying these therapies to individuals with type 1 diabetes for the prevention of CKD is of great importance.
Article
Urology & Nephrology
Robert A. Fletcher, Niels Jongs, Glenn M. Chertow, John J. V. Mcmurray, Clare Arnott, Meg J. Jardine, Kenneth W. Mahaffey, Vlado Perkovic, Patrick Rockenschaub, Peter Rossing, Ricardo Correa-Rotter, Robert D. Toto, Muthiah Vaduganathan, David C. Wheeler, Hiddo J. L. Heerspink, Brendon L. Neuen
Summary: This study analyzed the effect of SGLT2 inhibitors on the discontinuation of RAS blockade and found that patients receiving SGLT2 inhibitors had a lower risk of discontinuing RAS blockade. This effect was particularly pronounced in patients with a high baseline urinary albumin-to-creatinine ratio.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Hashmat Sayed Zohori Bahrami, Peter Godsk Jorgensen, Jens Dahlgaard Hove, Ulrik Dixen, Tor Biering-Sorensen, Peter Rossing, Magnus T. Jensen
Summary: Cardiovascular disease is the leading cause of death in type 1 and type 2 diabetes patients. The myocardial performance index (MPI), which reflects left ventricular function, has not been evaluated for its prognostic value in diabetes populations. This study evaluated two prospective cohort studies and found that MPI is associated with major adverse cardiovascular events and heart failure, particularly in type 1 diabetes patients, and improves prediction in this group.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Gastroenterology & Hepatology
Morten A. Karsdal, Kate Hallsworth, Jadine Scragg, Diana J. Leeming, Ida F. Villesen, Leah Avery, Laura Haigh, Olivier Govaere, Sarah Wichmann, Guy Taylor, Sophie Cassidy, Stuart Mcpherson, Quentin M. Anstee
Summary: The amount of fibroblast activity in patients with NAFLD can be defined by circulating biomarkers of collagen formation. The high-risk, high-fibrogenesis patient endotype with greater fibroblast activity exhibited a marked reduction in collagen fibrogenesis with a very low-calorie diet intervention, while fibrogenesis remained unchanged in the low activity group. The quantification of fibrogenesis biomarkers at baseline can predict the likelihood of treatment response.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Urology & Nephrology
Katherine R. R. Tuttle, Jonathan M. Wilson, Yanzhu Lin, Hui-Rong Qian, Federica Genovese, Morten A. Karsdal, Kevin L. L. Duffin, Fady T. Botros
Summary: In the AWARD-7 study, once-weekly dulaglutide treatment in patients with type 2 diabetes and chronic kidney disease demonstrated a slower decline in eGFR and a reduction in urine albumin/creatinine ratio compared to insulin glargine. This exploratory analysis found that dulaglutide treatment was associated with lower levels of PRO-C6 and higher levels of C3M, indicating reduced type VI collagen formation and increased type III collagen degradation, suggesting a potential mechanism for reducing kidney fibrosis.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)