ALKBH5‐mediated m 6 A demethylation of TIRAP mRNA promotes radiation‐induced liver fibrosis and decreases radiosensitivity of hepatocellular carcinoma

Kinsenoside Protects Against Radiation-Induced Liver Fibrosis via Downregulating Connective Tissue Growth Factor Through TGF-β1 Signaling

(2022) Xiaoqi Nie et al.   Frontiers in Pharmacology

ALKBH5 ameliorated liver fibrosis and suppressed HSCs activation via triggering PTCH1 activation in an m6A dependent manner

(2022) Jing-Jing Yang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5–RNA complexes

(2022) Simranjeet Kaur et al.   NUCLEIC ACIDS RESEARCH

How Human TET2 Enzyme Catalyzes the Oxidation of Unnatural Cytosine Modifications in Double-Stranded DNA

(2022) Sodiq O. Waheed et al.   ACS Catalysis

AIF1 + CSF1R + MSCs , induced by TNF ‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

(2022) Chen Zong et al.   HEPATOLOGY

Catalytic Mechanism of Human Ten-Eleven Translocation-2 (TET2) Enzyme: Effects of Conformational Changes, Electric Field, and Mutations

(2021) Sodiq O. Waheed et al.   ACS Catalysis

Phase 2 Study of Adjuvant Radiotherapy Following Narrow‐Margin Hepatectomy in Patients With HCC

(2021) Bo Chen et al.   HEPATOLOGY

Circular RNA RSF1 promotes inflammatory and fibrotic phenotypes of irradiated hepatic stellate cell by modulating miR‐146a‐5p

(2020) Yuhan Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis

(2020) Jiazhen Wang et al.   Cell Stem Cell

Epitranscriptomics in liver disease: Basic concepts and therapeutic potential

(2020) Zhicong Zhao et al.   JOURNAL OF HEPATOLOGY

Role of Structural Dynamics in Selectivity and Mechanism of Non-heme Fe(II) and 2-Oxoglutarate-Dependent Oxygenases Involved in DNA Repair

(2020) Sodiq O. Waheed et al.   ACS Central Science

The Role of Sirtuin 3 in Radiation-Induced Long-Term Persistent Liver Injury

(2020) Francesca V. LoBianco et al.   Antioxidants

Zbtb7b suppresses aseptic inflammation by regulating m6A modification of IL6 mRNA

(2020) Jun Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Radiation-induced liver disease in the era of SBRT: a review

(2020) Carolina De La Pinta Alonso   Expert Review of Gastroenterology & Hepatology

Neoadjuvant Three-Dimensional Conformal Radiotherapy for Resectable Hepatocellular Carcinoma With Portal Vein Tumor Thrombus: A Randomized, Open-Label, Multicenter Controlled Study

(2019) Xubiao Wei et al.   JOURNAL OF CLINICAL ONCOLOGY

FTO regulates the chemo-radiotherapy resistance of cervical squamous cell carcinoma (CSCC) by targeting β-catenin through mRNA demethylation

(2018) Shun Zhou et al.   MOLECULAR CARCINOGENESIS

Insight into wild-type and T1372E TET2-mediated 5hmC oxidation using ab initio QM/MM calculations

(2018) Hedieh Torabifard et al.   Chemical Science

Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistance

(2017) A Visvanathan et al.   ONCOGENE

Computational investigation of O2 diffusion through an intra-molecular tunnel in AlkB; influence of polarization on O2 transport

(2017) Hedieh Torabifard et al.   Chemical Science

Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA

(2016) Chuanzhao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative Pathway for the Reaction Catalyzed by DNA Dealkylase AlkB from Ab Initio QM/MM Calculations

(2014) Dong Fang et al.   Journal of Chemical Theory and Computation

The Inflammatory Chemokine CCL5 and Cancer Progression

(2014) Donatella Aldinucci et al.   MEDIATORS OF INFLAMMATION

Hedgehog Signaling Regulates the Repair Response in Mouse Liver Damaged by Irradiation

(2012) Sihyung Wang et al.   RADIATION RESEARCH