ALKBH5 ameliorated liver fibrosis and suppressed HSCs activation via triggering PTCH1 activation in an m6A dependent manner

ALKBH5-mediated m6A demethylation of FOXM1 mRNA promotes progression of uveal melanoma

(2021) Lili Hao et al.   Aging-US

c-Myc affects hedgehog pathway via KCNQ1OT1/RAC1: A new mechanism for regulating HSC proliferation and epithelial-mesenchymal transition

(2021) Yilei Deng et al.   DIGESTIVE AND LIVER DISEASE

A methionine-Mettl3-N-methyladenosine axis promotes polycystic kidney disease

(2021) Harini Ramalingam et al.   Cell Metabolism

Reactivation of the Hedgehog pathway in esophageal progenitors turns on an embryonic-like program to initiate columnar metaplasia

(2021) Alizée Vercauteren Drubbel et al.   Cell Stem Cell

Epigenetics-based therapeutics for myocardial fibrosis

(2021) Xuping Li et al.   LIFE SCIENCES

Pooled CRISPR screening identifies m6A as a positive regulator of macrophage activation

(2021) Jiyu Tong et al.   Science Advances

METTL3/METTL14 transactivation and m6A-dependent TGF-β1 translation in activated Kupffer cells

(2021) Yue Feng et al.   Cellular and Molecular Gastroenterology and Hepatology

METTL3/N6‐methyladenosine/ miR‐21‐5p promotes obstructive renal fibrosis by regulating inflammation through SPRY1/ERK/NF‐κB pathway activation

(2021) Erpeng Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase

(2021) Zhen Xia et al.   NUCLEIC ACIDS RESEARCH

Patched regulates lipid homeostasis by controlling cellular cholesterol levels

(2021) Carla E. Cadena del Castillo et al.   Nature Communications

N6-methyladenosine modification regulates ferroptosis through autophagy signaling pathway in hepatic stellate cells

(2021) Min Shen et al.   Redox Biology

m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer

(2020) Huilin Huang et al.   CANCER CELL

Programmable m6A modification of cellular RNAs with a Cas13-directed methyltransferase

(2020) Christopher Wilson et al.   NATURE BIOTECHNOLOGY

Epigenome‐wide analysis of methylation changes in the sequence of gallstone disease, dysplasia, and gallbladder cancer

(2020) Johannes Brägelmann et al.   HEPATOLOGY

Cholesterol access in cellular membranes controls Hedgehog signaling

(2020) Arun Radhakrishnan et al.   Nature Chemical Biology

Genistein Ameliorates Renal Fibrosis Through Regulation Snail via m6A RNA Demethylase ALKBH5

(2020) Yichun Ning et al.   Frontiers in Pharmacology

Targeting Nestin+ hepatic stellate cells ameliorates liver fibrosis by facilitating TβRI degradation

(2020) Huaxin Chen et al.   JOURNAL OF HEPATOLOGY

Icariin‐induced miR‐875‐5p attenuates epithelial‐mesenchymal transition by targeting hedgehog signaling in liver fibrosis

(2019) Lei Ye et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism

(2018) Ying Yang et al.   CELL RESEARCH

Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells

(2018) Kuo Du et al.   GASTROENTEROLOGY

Epigenetic aberrations of miR-369-5p and DNMT3A control Patched1 signal pathway in cardiac fibrosis

(2018) Hui Tao et al.   TOXICOLOGY

The long noncoding RNA LncHDAC2 drives the self-renewal of liver cancer stem cells via activation of Hedgehog Signaling

(2018) Jiayi Wu et al.   JOURNAL OF HEPATOLOGY

The PNPLA3 I148M variant modulates the fibrogenic phenotype of human hepatic stellate cells

(2017) Francesca Virginia Bruschi et al.   HEPATOLOGY

Basal Cell Carcinoma Preferentially Arises from Stem Cells within Hair Follicle and Mechanosensory Niches

(2015) Shelby C. Peterson et al.   Cell Stem Cell

Salvianolic acid B-induced microRNA-152 inhibits liver fibrosis by attenuating DNMT1-mediated Patched1 methylation

(2015) Fujun Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Alcohol directly stimulates epigenetic modifications in hepatic stellate cells

(2015) Agata Page et al.   JOURNAL OF HEPATOLOGY

Hedgehog Controls Hepatic Stellate Cell Fate by Regulating Metabolism

(2012) Yuping Chen et al.   GASTROENTEROLOGY

Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells

(2007) Liu Yang et al.   JOURNAL OF HEPATOLOGY