Article
Cardiac & Cardiovascular Systems
Ravi B. Patel, Jozine M. Ter Maaten, Joao Pedro Ferreira, Finnian R. McCausland, Sanjiv J. Shah, Patrick Rossignol, Scott D. Solomon, Muthiah Vaduganathan, Milton Packer, Aliza Thompson, Norman Stockbridge, Faiez Zannad
Summary: Patients with chronic cardiovascular or metabolic diseases often have comorbid kidney disease, leading to worse long-term outcomes. Certain novel treatments have shown beneficial effects on both cardiac and kidney outcomes, sparking interest in formally acknowledging and defining composite cardio-kidney outcomes in future cardiovascular trials.
Article
Cardiac & Cardiovascular Systems
Liam Gaziano, Luanluan Sun, Matthew Arnold, Steven Bell, Kelly Cho, Stephen K. Kaptoge, Rebecca J. Song, Stephen Burgess, Daniel C. Posner, Katja Mosconi, Cassianne Robinson Cohen, Amy M. Mason, Thomas R. Bolton, Ran Tao, Elias Allara, Petra Schubert, Lingyan Chen, James R. Staley, Natalie Staplin, Servet Altay, Pilar Amiano, Phar Volker Arndt, Johan Arnlov, Elizabeth L. M. Barr, Cecilia Bjorkelund, Jolanda M. A. Boer, Hermann Brenner, Edoardo Casiglia, Paolo Chiodini, Jackie A. Cooper, Josef Coresh, Mary Cushman, Rachel Dankner, Karina W. Davidson, Renate T. de Jongh, Chiara Donfrancesco, Gunnar Engstrom, Heinz Freisling, Agustin Gomez de la Camara, Vilmundur Gudnason, Graeme J. Hankey, PerOlof Hansson, Alicia K. Heath, Ewout J. Hoorn, Hironori Imano, Simerjot K. Jassal, Rudolf Kaaks, Verena Katzke, Jussi Kauhanen, Stefan Kiechl, Wolfgang Koenig, Richard A. Kronmal, Cecilie Kyro, Deborah A. Lawlor, Borje Ljungberg, Conor MacDonald, Giovanna Masala, Christa Meisinger, Olle Melander, Conchi Moreno Iribas, Toshiharu Ninomiya, Dorothea Nitsch, Borge G. Nordestgaard, Charlotte OnlandMoret, Luigi Palmieri, Dafina Petrova, Jose Ramon Quiros Garcia, Annika Rosengren, Carlotta Sacerdote, Masaru Sakurai, Carmen Santiuste, Matthias B. Schulze, Sabina Sieri, Johan Sundstrom, Valerie Tikhonoff, Anne Tjonneland, Tammy Tong, Rosario Tumino, Ioanna Tzoulaki, Yvonne T. van der Schouw, W. M. Monique Verschuren, Henry Volzke, Robert B. Wallace, S. Goya Wannamethee, Elisabete Weiderpass, Peter Willeit, Mark Woodward, Kazumasa Yamagishi, Raul ZamoraRos, Elvis A. Akwo, Saiju Pyarajan, David R. Gagnon, Philip S. Tsao, Sumitra Muralidhar, Todd L. Edwards, Scott M. Damrauer, Jacob Joseph, Lisa Pennells, Peter W. F. Wilson, Seamus Harrison, Thomas A. Gaziano, Michael Inouye, Colin Baigent, Juan P. Casas, Claudia Langenberg, Nick Wareham, Elio Riboli, J. Michael Gaziano, John Danesh, Adriana M. Hung, Adam S. Butterworth, Angela M. Wood, Emanuele Di Angelantonio
Summary: The study results suggest that mild-to-moderate kidney dysfunction is causally related to the risk of coronary heart disease in people without manifest cardiovascular disease or diabetes.
Review
Biochemistry & Molecular Biology
Maria Raza Tokatli, Leuconoe Grazia Sisti, Eleonora Marziali, Lorenza Nachira, Maria Francesca Rossi, Carlotta Amantea, Umberto Moscato, Walter Malorni
Summary: This article provides a broad review of the role of hormone regulation in gender medicine and gender differences across key clinical areas. The study highlights the influence of sex differences in immune response, cardiovascular diseases, neurological disorders, cancer, and COVID-19. It also emphasizes the importance of gender implications in occupational health and health policy, calling for more personalized clinical medicine and public health approaches.
Review
Cardiac & Cardiovascular Systems
Sarah M. Nwia, Ana Paula O. Leite, Xiao Chun Li, Jia Long Zhuo
Summary: Cardiovascular disease demonstrates significant biological sex differences, allowing for tailored approaches to prevention and treatment. Hypertension, a major risk factor for various diseases, affects a significant percentage of the American population. Women have lower rates of hypertension during reproductive years, but this protection diminishes after menopause. Treatment-resistant hypertension remains a challenge, suggesting unknown mechanisms in blood pressure regulation. Understanding the genetic and hormonal differences in hypertension can lead to sex-specific treatments and improved outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Biology
Chrysoula Boutari, Fotios Siskos
Summary: Resistant hypertension refers to the inability to control blood pressure despite triple combination therapy. The endothelin system plays a role in regulating vascular tone and cardiac contractility, as well as water and sodium reabsorption. Endothelin inhibitors, originally used for pulmonary hypertension, show promise in treating essential hypertension and resistant hypertension. Aprocitentan, a novel dual endothelin receptor antagonist, has shown promising results in experimental studies and clinical trials, providing a potential solution for managing resistant hypertension.
Review
Medicine, General & Internal
Katarzyna Czajkowska, Edyta Zbroch, Angelika Bielach-Bazyluk, Katarzyna Mitrosz, Elzbieta Bujno, Katarzyna Kakareko, Alicja Rydzewska-Rosolowska, Tomasz Hryszko
Summary: As the aging population sees a rise in cardiovascular and chronic kidney diseases, mortality rates are increasing, leading to significant public health and economic burdens. Identifying easy prognostic markers and early diagnosis are crucial for effective therapy and reduced morbidity. Mid-regional proadrenomedullin shows promise as a novel biomarker for cardiovascular risk and kidney disease progression.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Hiddo J. L. Heerspink, Jai Radhakrishnan, Charles E. Alpers, Jonathan Barratt, Stewart Bieler, Ulysses Diva, Jula Inrig, Radko Komers, Alex Mercer, Irene L. Noronha, Michelle N. Rheault, William Rote, Brad Rovin, Howard Trachtman, Hernin Trimarchi, Muh Geot Wong, Vlado Perkovic
Summary: This study investigates the efficacy and safety of sparsentan, a novel medication, in adults with IgA nephropathy. The results demonstrate that sparsentan treatment significantly reduces proteinuria compared to irbesartan, with similar safety profiles. Further long-term studies are required to confirm the nephroprotective potential of sparsentan.
Article
Cardiac & Cardiovascular Systems
Manovriti Thakur, Carolina Victoria Cruz Junho, Sarah Maike Bernhard, Marc Schindewolf, Heidi Noels, Yvonne Doering
Summary: Arterial and venous thrombosis are significant causes of morbidity and mortality worldwide. The association between thrombotic complications and cardiovascular and chronic inflammatory diseases is well-established. Inflammation and immunothrombosis, the initiation of thrombotic events, are gaining attention, but still not fully understood. However, the clinical relevance of aberrant immunothrombosis, known as thromboinflammation, is evident by the increased risk of thrombosis and cardiovascular events in patients with inflammatory or infectious diseases. This review focuses on the interrelationships and functions between NETs and other mediators in cardiovascular disease, as well as neutrophil phenotype, function, and NET formation in chronic kidney disease. Therapeutic targeting of NETs-induced immunothrombosis is also discussed as a potential intervention beyond current treatment options.
CIRCULATION RESEARCH
(2023)
Article
Peripheral Vascular Disease
Muhammad B. Khan, Rebecca Scherzer, Cora E. Lewis, Rakesh Malhotra, Joachim H. Ix, Michael G. Shlipak, Orlando M. Gutierrez
Summary: This study examined the associations between urine biomarkers and incident hypertension in young adults, and found that higher levels of urine EGF were associated with a lower risk of developing hypertension and lower increases in blood pressure over a 10-year period.
Article
Medicine, General & Internal
Lei Tang, Lina Yang, Wenwen Chen, Chunyang Li, Yu Zeng, Huazhen Yang, Yao Hu, Yuanyuan Qu, Huan Song, Xiaoxi Zeng, Ping Fu
Summary: This study investigated the relationship between coffee and chronic kidney disease, finding a dose-dependent inverse association. The study also identified a sex disparity, with coffee only being associated with a reduced risk of chronic kidney disease in females. Testosterone and SHBG may partly account for this sex disparity.
CHINESE MEDICAL JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Marie de Bakker, Atul Anand, Martin Shipley, Takeshi Fujisawa, Anoop S. V. Shah, Isabella Kardys, Eric Boersma, Eric J. J. Brunner, Nicholas L. L. Mills, Dorien M. M. Kimenai
Summary: The study found that cardiac troponin concentrations are lower in women than men. The trajectory of cardiac troponin differs between sexes and is associated with cardiovascular outcomes, highlighting the importance of a sex-specific approach in cardiovascular risk prediction.
Article
Rheumatology
Tea Gegenava, Federico Fortuni, Nina Marijn van Leeuwen, Anders H. Tennoe, Anna-Maria Hoffmann-Vold, Ruxandra Jurcut, Adrian Giuca, Laura Groseanu, Felix Tanner, Oliver Distler, Jeroen J. Bax, Jeska De Vries-Bouwstra, Nina Ajmone Marsan
Summary: This study aimed to assess the impact of sex differences on cardiovascular outcomes in patients with systemic sclerosis (SSc). The results showed that male SSc patients had a higher incidence of cardiovascular events, and the adjusted left ventricular global longitudinal strain may explain this gender difference in outcomes.
Review
Medicine, Research & Experimental
Hao-lu Sun, Qiu-ying Ma, He-ge Bian, Xiao-ming Meng, Juan Jin
Summary: The gastrin-releasing peptide receptor (GRPR), a member of G protein-coupled receptors (GPCRs), plays various biological roles by binding to ligands such as gastrin-releasing peptide (GRP). The GRP/GRPR signaling is involved in the pathophysiological processes of inflammatory diseases, cardiovascular diseases, neurological diseases, and different types of cancers. The potential of the GRP/GRPR axis as a therapeutic target for multiple diseases and its crucial role in disease progression emphasize the importance of studying this signaling axis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Peripheral Vascular Disease
Naima Covassin, Jan Bukartyk, Prachi Singh, Andrew D. Calvin, Erik K. St Louis, Virend K. Somers
Summary: Prolonged sleep restriction leads to increased blood pressure, impaired endothelial function, and elevated plasma norepinephrine levels. Despite more deep sleep, blood pressure remains elevated during sleep. Women show more pronounced and sustained cardiovascular effects from sleep loss.
Article
Peripheral Vascular Disease
Chloe Douglas, Jennifer T. Roem, Joseph L. Flynn, Susan A. Furth, Bradley M. Warady, Susan Halbach
Summary: Using data from the CKiD Study, this study found that younger children with chronic kidney disease are more likely to have unrecognized and untreated hypertensive blood pressure, highlighting the need for efforts to improve blood pressure control in this population.
Article
Pharmacology & Pharmacy
Tiago J. Costa, Simone R. Potje, Thais F. C. Fraga-Silva, Julio A. Da Silva-Neto, Paula R. Barros, Daniel Rodrigues, Mirele R. Machado, Ronaldo B. Martins, Rosangela A. Santos-Eichler, Maira N. Benatti, Keyla S. G. de Sa, Carlos Eduardo L. Almado, Italo A. Castro, Marjorie C. Pontelli, Leonardo La Serra, Fernando S. Carneiro, Christiane Becari, Paulo Louzada-Junior, Rene D. R. Oliveira, Dario S. Zamboni, Eurico Arruda, Maria Auxiliadora-Martins, Fernanda R. C. Giachini, Vania L. D. Bonato, Natasha E. Zachara, Gisele F. Bomfim, Rita C. Tostes
Summary: This study demonstrates that SARS-CoV-2 infection impairs mitochondrial function and activates TLR9 signaling in endothelial cells, leading to inflammatory responses and endothelial dysfunction. Targeting mitochondrial metabolic pathways may offer new therapeutic strategies for COVID-19.
VASCULAR PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Eman Y. Gohar, Carmen De Miguel, Ijeoma E. Obi, Elizabeth M. Daugherty, Kelly A. Hyndman, Bryan K. Becker, Chunhua Jin, Randee Sedaka, Jermaine G. Johnston, Pengyuan Liu, Joshua S. Speed, Tanecia Mitchell, Alison J. Kriegel, Jennifer S. Pollock, David M. Pollock
Summary: This study found that female rats have a greater ability to adapt to increased dietary salt intake challenges, suggesting that female sex confers a greater ability to maintain Na+ homeostasis. Additionally, the study discovered that the intrarenal endothelin-1 natriuretic pathway is enhanced in women, which may contribute to their better ability to regulate sodium levels.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Physiology
Gabriel Gomes Araujo, Rinaldo Rodrigues dos Passos Junior, Rosaline Rocha Lunardi, Gustavo Tadeu Volpato, Thaigra Sousa Soares, Fernanda Regina Giachini, Victor Vitorino Lima
Summary: This study evaluated the use of etanercept during pregnancy and found that it can cause harm to the fetus and placenta. However, further studies are needed to determine the appropriate dosage and potential risks.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Thais Leal-Silva, Maysa Rocha Souza, Larissa Lopes Cruz, Rafaianne Queiroz Moraes-Souza, Veronyca Goncalves Paula, Thaigra Sousa Soares, Vanessa Dela Justina, Fernanda Regina Giachini, Debora Cristina Damasceno, Madileine Francely Americo, Gustavo Tadeu Volpato
Summary: This study evaluated the effects of Morinda citrifolia fruit extract on maternal performance and fetal development in rats. The results showed that high doses of the extract can cause maternal hepatotoxicity, anti-implantation effects, and fetal abnormalities.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Review
Physiology
Tiago J. Costa, Julio Cezar De Oliveira, Fernanda Regina Giachini, Victor Vitorino Lima, Rita C. Tostes, Gisele Facholi Bomfim
Summary: Growing evidence suggests that insults during pregnancy can affect the vascular function and immune response of offspring. Overactivation of the immune system has a negative impact on cardiovascular function. This review discusses the potential link between prenatal stress and offspring vascular dysfunction through modulation of the immune system.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Physiology
Paola Ayala-Ramirez, Marcelo Gonzalez, Carlos Escudero, Laura Quintero-Arciniegas, Fernanda R. Giachini, Raiany Alves de Freitas, Alicia E. Damiano, Reggie Garcia-Robles
Summary: COVID-19 infection during pregnancy can have negative effects on pregnant women, causing severe systemic inflammatory response, vascular alterations, and abnormal placental histology. However, the risks of administering COVID-19 vaccines during pregnancy appear to be minimal.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Immunology
Rinaldo Rodrigues dos Passos Junior, Gisele Facholi Bomfim, Fernanda R. Giachini, Rita C. Tostes, Victor Vitorino Lima
Summary: The O-GlcNAcylation modification of proteins plays a significant role in cardiovascular diseases, including hypertension. Recent studies have shown that components of innate and adaptive immunity are targets for O-GlcNAcylation and may contribute to arterial hypertension.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ravneet Singh, Victoria L. Nasci, Ginger Guthrie, Lale A. Ertuglu, Maryam K. Butt, Annet Kirabo, Eman Y. Gohar
Summary: Cardiovascular and renal diseases are increasingly prevalent and age and sex differences play a role in their development and progression. GPER1 has been identified as an important regulator in cardio-renal health, particularly in aging individuals.
Article
Cell Biology
Rafael Sobrano Fais, Rafael Menezes da Costa, Allan Carvalho Mendes, Fabiola Mestriner, Simon Gabriel Comerma-Steffensen, Rita C. Tostes, Ulf Simonsen, Fernando Silva Carneiro
Summary: In this study, it was hypothesized that stimulation of endothelin receptors ETA and ETB leads to NLRP3 activation through increased calcium and ROS formation. The experiments conducted on mice demonstrated that ET-1 reduced intracavernosal pressure and the CC ACh and SNP-induced relaxation, while increasing caspase-1 expression. The use of receptor antagonists, genetic deletion, and ROS inhibitors reversed these effects, indicating that ET-1-induced erectile dysfunction involves the activation of NLRP3 via Ca2+-dependent ROS generation mediated by ETA- and ETB-receptors.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Developmental Biology
Alejo Macias-Salas, Martha Sosa-Macias, Laura Jazel Barragan-Zuniga, Ricardo Blanco-Castaneda, Alicia Damiano, Reggie Garcia-Robles, Paola Ayala-Ramirez, Julio Bueno-Sanchez, Fernanda Regina Giachini, Carlos Escudero, Carlos Galaviz-Hernandez
Summary: This study aimed to evaluate whether placental nucleotide variations on eNOS, VEGFA, and FLT-1 genes are more frequently associated with preeclampsia in the Latin American population. The results showed that the VEGFA gene's SNV rs2010963 was significantly associated with preeclampsia, while the allele combination T, G, G, C, C, C may represent potential protective factors for preeclampsia in Latin American women.
Review
Cardiac & Cardiovascular Systems
Jeimison D. Santos, Rita C. Tostes, Jose T. Oliveira-Neto
Summary: The growing number of transgender individuals has gained attention and will impact clinical practices worldwide. Testosterone, the main hormone used in gender-affirming hormone therapy, can have harmful cardiovascular effects, and thus requires close attention in clinical use.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Endocrinology & Metabolism
Victoria L. Nasci, Rawan N. Almutlaq, David M. Pollock, Eman Y. Gohar
Summary: Current understanding of sodium handling is primarily based on studies in males. This study found that female rats have a robust natriuresis after 1 day of high salt diet, while males show a gradual increase over 3-5 days. Endothelin-1 signaling through ET receptors is implicated in the sex-differences in sodium handling, with the receptors mediating the augmented natriuretic capacity in females.
BIOLOGY OF SEX DIFFERENCES
(2023)
Review
Medicine, Research & Experimental
Tiago J. Costa, Emily W. Wilson, Milene T. Fontes, Laena Pernomian, Rita C. Tostes, Camilla F. Wenceslau, Cameron G. McCarthy
Summary: O-GlcNAcylation is a widespread and dynamic post-translational modification that affects the function and stability of target proteins. It modulates cellular signaling and transcription regulatory pathways in response to nutrients and stress. It is associated with cardiovascular diseases and has the potential to serve as a novel target for their treatment and prevention.
Article
Physiology
Rawan N. Almutlaq, Annie E. Newell-Fugate, Louise C. Evans, Huma Fatima, Eman Y. Gohar
Summary: Aromatase inhibition increases blood pressure and induces kidney injury in female rats.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Meeting Abstract
Developmental Biology
Rinaldo Rodrigues dos Passos Junior, Raiany Alves de Freitas, Vanessa Dela Justina, Camila Werle Bach, Sebastian San Martin, Victor Vitorino Lima, Fernanda Regina Giachini
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.
