Article
Endocrinology & Metabolism
Victoria L. Nasci, Rawan N. Almutlaq, David M. Pollock, Eman Y. Gohar
Summary: Current understanding of sodium handling is primarily based on studies in males. This study found that female rats have a robust natriuresis after 1 day of high salt diet, while males show a gradual increase over 3-5 days. Endothelin-1 signaling through ET receptors is implicated in the sex-differences in sodium handling, with the receptors mediating the augmented natriuretic capacity in females.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Pharmacology & Pharmacy
Bozena Badzynska, Ivana Vaneckova, Janusz Sadowski, Silvie Hojna, Elzbieta Kompanowska-Jezierska
Summary: This study investigated the effects of ETA and ETB receptor blockade on blood pressure, medullary blood flow, and tissue NO in different rat models. The results confirmed the dominant role of ETA receptors in regulating blood pressure and renal hemodynamics in both normotensive and hypertensive rats. Additionally, ETB stimulation was found to preserve medullary perfusion under conditions of endothelin system activation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
John G. Kingma, Ismail Laher
Summary: The study revealed sex differences in coronary resistance vessels, with male vessels being more sensitive to the vasoconstrictor effects of ET-1. Responses to ET-1 were normalized in male and female (not studied in ovariectomized) groups after exposure to L-NAME.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Neurosciences
Laura A. Richards, Christopher M. Schonhoff
Summary: This article discusses the important roles of nitric oxide in the nervous system, including its discovery, molecular biology, and chemistry, as well as its role in dendritic development and sex differences during neurodevelopment.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Peripheral Vascular Disease
Gaizun Hu, Qing Zhu, Weili Wang, Dengpiao Xie, Chaoling Chen, Pin-Lan Li, Joseph K. Ritter, Ningjun Li
Summary: The study shows that the CD-S1PR1 pathway is crucial for sodium excretion and its deletion leads to sodium retention and exacerbates the development of salt-sensitive hypertension.
JOURNAL OF HYPERTENSION
(2021)
Article
Dentistry, Oral Surgery & Medicine
Janos Vag, Tamas Laszlo Nagy, Barbara Mikecs
Summary: Sex hormones have an influence on gingival blood flow, with males having higher baseline blood flow and more pronounced endothelium-dependent vasodilation. This may contribute to the increased severity of periodontal disease in men.
Review
Biochemistry & Molecular Biology
Ravneet Singh, Victoria L. Nasci, Ginger Guthrie, Lale A. Ertuglu, Maryam K. Butt, Annet Kirabo, Eman Y. Gohar
Summary: Cardiovascular and renal diseases are increasingly prevalent and age and sex differences play a role in their development and progression. GPER1 has been identified as an important regulator in cardio-renal health, particularly in aging individuals.
Article
Peripheral Vascular Disease
Reham H. Soliman, Chunhua Jin, Crystal M. Taylor, Emile Moura Coelho da Silva, David M. Pollock
Summary: This study found that diet-induced obesity impairs renal handling of an acute salt load in male rats, leading to reduced natriuretic response and lower renal endothelin function. Female rats, on the other hand, were not salt sensitive and did not show changes in renal endothelin excretion. Obesity in males also resulted in higher blood pressure, which was further exacerbated by high salt intake.
Review
Biochemistry & Molecular Biology
Peter J. Little, Christopher D. Askew, Suowen Xu, Danielle Kamato
Summary: The endothelium is a single-cell monolayer that lines the entire vasculature, playing roles in barrier function, anticoagulation, vascular aging, endocrine secretion, and inflammation suppression. It produces important factors like nitric oxide and endothelin, with continued research on endothelial dysfunction leading to potential novel cardiovascular therapies.
Article
Physiology
Agnaldo Bruno Chies, Maria Angelica Spadella, Priscila Ramos de Oliveira, Raquel Fantin Domeniconi, Talita de Mello Santos, Roseli Peres Moreira, Carla B. Rosales, Dulce Elena Casarini, Luis Gabriel Navar
Summary: This study found that NO reduces Ang II responses in femoral veins of 2K1C hypertensive rats, while exercise mobilizes vasodilator prostanoids to maintain controlled Ang II responses in the veins.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Physiology
Takayuki Matsumoto, Keisuke Takayanagi, Mihoka Kojima, Kumiko Taguchi, Tsuneo Kobayashi
Summary: The study demonstrates that indoxyl sulfate enhances ET-1-induced contraction in rat aortas through impairment of NO/cGMP signaling and antioxidant systems.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Hae Min Kang, Md. Hasanuzzaman, So Won Kim, Hyoung Jun Koh, Sung Chul Lee
Summary: This study compared aqueous humor concentrations of ET-1 in patients with CRVO, BRVO, and a normal control group. The findings showed that ET-1 levels were significantly higher in CRVO patients compared to BRVO patients and controls, and after IVB treatment, levels were significantly decreased in both CRVO and BRVO patients.
Article
Cardiac & Cardiovascular Systems
Yujin Wang, Yuqin Wang, Tiaoxia Liu, Yifan Qin, Futian Tang, Xiaowei Zhang, Yongnan Li
Summary: This study found a strong association between ET-1, NO, and CCS severity. A combination of ET-1, NO, and GS is an essential predictor of CCS disease severity.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Raul Lopez-Fernandez-Sobrino, Jorge R. Soliz-Rueda, Javier Avila-Roman, Anna Arola-Arnal, Manuel Suarez, Begona Muguerza, Francisca Isabel Bravo
Summary: The study found that wine lees powder has antihypertensive effects related to flavanols, anthocyanins, and endothelial factors, reducing blood pressure by affecting NO and prostacyclin production. Additionally, the antihypertensive effect of wine lees powder is mediated by SIRT1, leading to increased expression of eNos and Sirt1 genes.
Article
Physiology
Alissa A. Frame, Kayla M. Nist, Kiyoung Kim, Jill T. Kuwabara, Richard D. Wainford
Summary: This study suggests that the renal sympathetic nerves, mediated by the alpha(1)-adrenoceptors, play a critical role in the natriuretic and sympathoinhibitory responses to acute increases in total body sodium, independent of blood pressure.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Eman Y. Gohar, Elizabeth M. Daugherty, Jeffrey O. Aceves, Randee Sedaka, Ijeoma E. Obi, J. Miller Allan, Reham H. Soliman, Chunhua Jin, Carmen De Miguel, Sarah H. Lindsey, Jennifer S. Pollock, David M. Pollock
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Review
Biochemistry & Molecular Biology
Tanecia Mitchell, Carmen De Miguel, Eman Y. Gohar
Article
Physiology
Eman Y. Gohar, Rawan N. Almutlaq, Elizabeth M. Daugherty, Maryam K. Butt, Chunhua Jin, Jennifer S. Pollock, David M. Pollock, Carmen De Miguel
Summary: Recent evidence suggests that GPER1 activation plays a crucial role in maintaining cardiovascular and kidney health in females. The study found that GPER1 activation can protect female Dahl SS rats from hypertension and kidney damage induced by a high-salt diet by preserving proximal tubule brush-border integrity and preventing proteinuria and albuminuria.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Editorial Material
Medicine, Research & Experimental
Michael P. Hutchens, Carmen De Miguel
Summary: Despite the increasing numbers of patients affected by cardiorenal syndrome, there is still a lack of complete understanding of the molecular pathways involved in its development and progression. Nitric oxide synthase (NOS) may play a role in cardiorenal syndrome, particularly in CRS2, but complexities and paradoxical clinical findings have limited translation efforts. Giam et al. highlight the role of a key NOS substrate transporter, cationic amino acid transporter-1, in preserving renal function in CRS2, offering exciting translational implications.
Review
Biochemistry & Molecular Biology
Carmen De Miguel, Pablo Pelegrin, Alberto Baroja-Mazo, Santiago Cuevas
Summary: Inflammasomes and pyroptosis play crucial roles in the development of hypertension, with pharmacological inhibition of inflammasomes leading to reduced blood pressure. This pathway shows potential as a future anti-hypertensive strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ravneet Singh, Victoria L. Nasci, Ginger Guthrie, Lale A. Ertuglu, Maryam K. Butt, Annet Kirabo, Eman Y. Gohar
Summary: Cardiovascular and renal diseases are increasingly prevalent and age and sex differences play a role in their development and progression. GPER1 has been identified as an important regulator in cardio-renal health, particularly in aging individuals.
Article
Biochemistry & Molecular Biology
Eman Y. Gohar, Rawan N. Almutlaq, Chunlan Fan, Rohan S. Balkawade, Maryam K. Butt, Lisa M. Curtis
Summary: This study suggests that G protein-coupled estrogen receptor 1 (GPER1) does not play a significant role in cisplatin-induced acute kidney injury (AKI), but its deletion exacerbates renal apoptosis and diminishes heme oxygenase-1 (HO-1) induction, indicating potentially important cytoprotective and anti-apoptotic actions of GPER1 in AKI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Michael A. Flinn, Santiago Alvarez-Argote, Makenna C. Knas, Victor Alencar Almeida, Samantha J. Paddock, Xiaoxu Zhou, Tyler Buddell, Ayana Jamal, Reiauna Taylor, Pengyuan Liu, Jenny Drnevich, Michaela Patterson, Brian A. Link, Caitlin C. O'Meara
Summary: This study investigates the role of Yap and Wwtr1 in myofibroblasts following myocardial infarction, and finds that depletion of Yap/Wwtr1 can alleviate fibrosis and improve cardiac function. It also identifies Ccn3 as a downstream factor of Yap/Wwtr1 that contributes to adverse cardiac remodeling post myocardial infarction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Victoria L. Nasci, Rawan N. Almutlaq, David M. Pollock, Eman Y. Gohar
Summary: Current understanding of sodium handling is primarily based on studies in males. This study found that female rats have a robust natriuresis after 1 day of high salt diet, while males show a gradual increase over 3-5 days. Endothelin-1 signaling through ET receptors is implicated in the sex-differences in sodium handling, with the receptors mediating the augmented natriuretic capacity in females.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Physiology
Rawan N. Almutlaq, Annie E. Newell-Fugate, Louise C. Evans, Huma Fatima, Eman Y. Gohar
Summary: Aromatase inhibition increases blood pressure and induces kidney injury in female rats.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Eman Y. Gohar, David M. Pollock
Summary: This study demonstrates that activation of renal medullary GPER1 can induce natriuresis in female rats via ETA and ETB receptors, with simultaneous antagonism of both receptors completely abolishing the effect.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2021)