Heme Scavenging and Delivery: The Role of Human Serum Albumin

Serum albumin and nucleic acids biodistribution: From molecular aspects to biotechnological applications

(2022) Gian Marco Vita et al.   IUBMB LIFE

A Recap of Heme Metabolism towards Understanding Protoporphyrin IX Selectivity in Cancer Cells

(2022) Martin Kiening et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tracking Heme-Protein Interactions in Healthy and Pathological Human Serum in Native Conditions by Miniaturized FFF-Multidetection

(2022) Valentina Marassi et al.   Applied Sciences-Basel

Biochemical characteristics of patients with imported malaria

(2022) Dewu Bi et al.   Frontiers in Cellular and Infection Microbiology

The Redox Balance and Membrane Shedding in RBC Production, Maturation, and Senescence

(2021) Eitan Fibach   Frontiers in Physiology

Heme Detoxification in the Malaria Parasite: A Target for Antimalarial Drug Development

(2021) Katherine A. de Villiers et al.   ACCOUNTS OF CHEMICAL RESEARCH

Serum Albumin: A Multifaced Enzyme

(2021) Giovanna De Simone et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hypoalbuminemia – An Indicator of the Severity and Prognosis of COVID-19 Patients: A Multicentre Retrospective Analysis

(2021) Chaoyue Chen et al.   Infection and Drug Resistance

Thalassemias: from gene to therapy

(2021) Giovanna De Simone et al.   MOLECULAR ASPECTS OF MEDICINE

From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme

(2020) Samantha A. Swenson et al.   Cells

Human Serum Albumin Facilitates Heme-Iron Utilization by Fungi

(2020) Mariel Pinsky et al.   mBio

Hypoalbuminemia, Coagulopathy, and Vascular Disease in COVID-19

(2020) Francesco Violi et al.   CIRCULATION RESEARCH

Haptoglobin: From hemoglobin scavenging to human health

(2020) Alessandra di Masi et al.   MOLECULAR ASPECTS OF MEDICINE

Haptoglobin and the related haptoglobin protein: the N-terminus makes the difference

(2020) Giovanna De Simone et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Desaturation and heme elevation during COVID-19 infection: a potential prognostic factor of heme oxygenase-1

(2020) Wen-Lin Su et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

SARS-CoV-2 Bound Human Serum Albumin and Systemic Septic Shock

(2020) Andrew S. Johnson et al.   Frontiers in Cardiovascular Medicine

Transferrin Receptors in Erythropoiesis

(2020) Cyrielle Richard et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Human Serum Albumin Binds Streptolysin O (SLO) Toxin Produced by Group A Streptococcus and Inhibits Its Cytotoxic and Hemolytic Effects

(2020) Gian Marco Vita et al.   Frontiers in Immunology

Cryo-EM structure of the human ferritin–transferrin receptor 1 complex

(2019) Linda Celeste Montemiglio et al.   Nature Communications

Structural basis of drug recognition by human serum albumin

(2019) Loris Leboffe et al.   CURRENT MEDICINAL CHEMISTRY

Heme Catabolic Pathway in Inflammation and Immune Disorders

(2019) Bing Wu et al.   Frontiers in Pharmacology

Labile heme impairs hepatic microcirculation and promotes hepatic injury

(2019) Franziska A. Englert et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Neonicotinoid trapping by the FA1 site of human serum albumin

(2019) Loris Leboffe et al.   IUBMB LIFE

Labile Heme Aggravates Renal Inflammation and Complement Activation After Ischemia Reperfusion Injury

(2019) Li Wang et al.   Frontiers in Immunology

Transferrin Receptors TfR1 and TfR2 Bind Transferrin through Differing Mechanisms

(2018) Mark D. Kleven et al.   BIOCHEMISTRY

Mechanisms of Hemolysis During Sepsis

(2018) Katharina Effenberger-Neidnicht et al.   INFLAMMATION

Human Serum Albumin is an Essential Component of the Host Defense Mechanism Against Clostridium difficile Intoxication

(2018) Alessandra di Masi et al.   JOURNAL OF INFECTIOUS DISEASES

Fipronil recognition by the FA1 site of human serum albumin

(2018) Paolo Ascenzi et al.   JOURNAL OF MOLECULAR RECOGNITION

Peroxidase Activity of Human Hemoproteins: Keeping the Fire under Control

(2018) Irina Vlasova   MOLECULES

The multifaceted role of complement in kidney transplantation

(2018) Ali-Reza Biglarnia et al.   Nature Reviews Nephrology

Warfarin inhibits allosterically the reductive nitrosylation of ferric human serum heme-albumin

(2017) Paolo Ascenzi et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Antibacterial Potential of an Antimicrobial Agent Inspired by Peroxidase-Catalyzed Systems

(2017) Lilit Tonoyan et al.   Frontiers in Microbiology

Red alert: labile heme is an alarmin

(2016) Miguel P Soares et al.   CURRENT OPINION IN IMMUNOLOGY

Human plasma lipocalins and serum albumin: Plasma alternative carriers?

(2016) Alessandra di Masi et al.   JOURNAL OF CONTROLLED RELEASE

Melatonin does not affect disseminated intravascular coagulation but diminishes decreases in platelet count during subacute endotoxaemia in rats

(2016) Maren Oude Lansink et al.   THROMBOSIS RESEARCH

Structural basis of haem-iron acquisition by fungal pathogens

(2016) Lena Nasser et al.   Nature Microbiology

Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease

(2015) F. Vinchi et al.   BLOOD

Drugs Modulate Allosterically Heme-Fe-Recognition by Human Serum Albumin and Heme-Fe-Mediated Reactivity

(2015) Alessandra Masi et al.   CURRENT PHARMACEUTICAL DESIGN

A clinical update of using albumin as a drug vehicle — A commentary

(2014) Felix Kratz   JOURNAL OF CONTROLLED RELEASE

Macrophages: central regulators of iron balance

(2014) Elena Gammella et al.   Metallomics

Albumin Replacement in Patients with Severe Sepsis or Septic Shock

(2014) Pietro Caironi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hemolysis-induced lethality involves inflammasome activation by heme

(2014) Fabianno F. Dutra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes

(2014) Deborah Chiabrando et al.   Frontiers in Pharmacology

Unraveling the mysteries of serum albumin—more than just a serum protein

(2014) Angelica M. Merlot et al.   Frontiers in Physiology

Albumin–drug interaction and its clinical implication

(2013) Keishi Yamasaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

HRG1 Is Essential for Heme Transport from the Phagolysosome of Macrophages during Erythrophagocytosis

(2013) Carine White et al.   Cell Metabolism

Hemopexin Therapy Improves Cardiovascular Function by Preventing Heme-Induced Endothelial Toxicity in Mouse Models of Hemolytic Diseases

(2013) Francesca Vinchi et al.   CIRCULATION

Cell-Free Hemoglobin

(2013) Matthias Hartmann et al.   CRITICAL CARE MEDICINE

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

(2012) D. J. Schaer et al.   BLOOD

Plasma methemoglobin as a potential biomarker of anemic stress in humans

(2012) Gregory M. T. Hare et al.   Canadian Journal of Anesthesia-Journal canadien d anesthesie

Structure of the haptoglobin–haemoglobin complex

(2012) Christian Brix Folsted Andersen et al.   NATURE

Measurement of macrophage marker in hyperhaemolytic transfusion reaction: a case report

(2012) N. Win et al.   TRANSFUSION MEDICINE

Heme Cytotoxicity and the Pathogenesis of Immune-Mediated Inflammatory Diseases

(2012) Rasmus Larsen et al.   Frontiers in Pharmacology

Control of intracellular heme levels: Heme transporters and heme oxygenases

(2011) Anwar A. Khan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

CO metabolism, sensing, and signaling

(2011) Francesca Gullotta et al.   BIOFACTORS

Sickle Hemoglobin Confers Tolerance to Plasmodium Infection

(2011) Ana Ferreira et al.   CELL

Human serum albumin improves endothelial dysfunction and survival during experimental endotoxemia: Concentration-dependent properties*

(2011) Hélène Kremer et al.   CRITICAL CARE MEDICINE

Association between hemolysis and albuminuria in adults with sickle cell anemia

(2011) T. G. Day et al.   HAEMATOLOGICA

Human serum albumin: From bench to bedside

(2011) Gabriella Fanali et al.   MOLECULAR ASPECTS OF MEDICINE

Mechanisms of Cell Protection by Heme Oxygenase-1

(2010) Raffaella Gozzelino et al.   Annual Review of Pharmacology and Toxicology

Allostery in a monomeric protein: The case of human serum albumin

(2010) Paolo Ascenzi et al.   BIOPHYSICAL CHEMISTRY

The Role of Iron and Chelators on Infections in Iron Overload and Non Iron Loaded Conditions: Prospects for the Design of New Antimicrobial Therapies

(2010) George J. Kontoghiorghes et al.   HEMOGLOBIN

Isoniazid and rifampicin inhibit allosterically heme binding to albumin and peroxynitrite isomerization by heme–albumin

(2010) Paolo Ascenzi et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Cubilin Is Essential for Albumin Reabsorption in the Renal Proximal Tubule

(2010) S. Amsellem et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Fowler Syndrome-Associated Protein FLVCR2 Is an Importer of Heme

(2010) S. P. Duffy et al.   MOLECULAR AND CELLULAR BIOLOGY

A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

(2010) R. Larsen et al.   Science Translational Medicine

Heme Scavenging and the Other Facets of Hemopexin

(2009) Emanuela Tolosano et al.   ANTIOXIDANTS & REDOX SIGNALING

Ibuprofen modulates allosterically NO dissociation from ferrous nitrosylated human serum heme-albumin by binding to three sites

(2009) Paolo Ascenzi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Serum heme-albumin: An allosteric protein

(2009) Paolo Ascenzi et al.   IUBMB LIFE

Abacavir and warfarin modulate allosterically kinetics of NO dissociation from ferrous nitrosylated human serum heme-albumin

(2008) Paolo Ascenzi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins

(2008) Abbhirami Rajagopal et al.   NATURE