CD34+ HSPCs-derived exosomes contain dynamic cargo and promote their migration through functional binding with the homing receptor E-selectin

Refining the migration and engraftment of short-term and long-term HSCs by enhancing homing-specific adhesion mechanisms

(2022) Asma S. Al-Amoodi et al.   Blood Advances

The spleen as a sanctuary site for residual leukemic cells following ABT-199 monotherapy in ETP-ALL

(2021) Alessandra Di Grande et al.   Blood Advances

Single-molecule imaging and microfluidic platform reveal molecular mechanisms of leukemic cell rolling

(2021) Bader Al Alwan et al.   Communications Biology

Critical Role of Lama4 for Hematopoiesis Regeneration and Acute Myeloid Leukemia Progression

(2021) Huan Cai et al.   BLOOD

Binding kinetics of liposome conjugated E-selectin and P-selectin glycoprotein ligand-1 measured with atomic force microscopy

(2021) Yuyuan Zhou et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Functional Binding of E-selectin to its Ligands is Enhanced by Structural Features Beyond its Lectin Domain

(2020) Fajr A Aleisa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fluorescent Multiplex Cell Rolling Assay: Simultaneous Capturing up to Seven Samples in Real-Time Using Spectral Confocal Microscopy

(2020) Ayman F. AbuElela et al.   ANALYTICAL CHEMISTRY

Splenomegaly Negatively Impacts Neutrophil Engraftment in Cord Blood Transplantation

(2020) Mitsuhiro Yuasa et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Using Eukaryotic Expression Systems to Generate Human α1,3-Fucosyltransferases That Effectively Create Selectin-Binding Glycans on Stem Cells

(2020) Asma S. Al-Amoodi et al.   BIOCHEMISTRY

Mesenchymal stem cell derived-exosomes: a modern approach in translational medicine

(2020) Sepideh Nikfarjam et al.   Journal of Translational Medicine

Cell migration and proliferation are regulated by miR-26a in colorectal cancer via the PTEN–AKT axis

(2019) Jossimar Coronel-Hernández et al.   Cancer Cell International

Mechanisms associated with biogenesis of exosomes in cancer

(2019) Kathleen M. McAndrews et al.   Molecular Cancer

Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis

(2019) Laura M. Doyle et al.   Cells

Toward understanding the origin and evolution of cellular organisms

(2019) Minoru Kanehisa   PROTEIN SCIENCE

Acute Myeloid and Lymphoblastic Leukemia Cell Interactions with Endothelial Selectins: Critical Role of PSGL-1, CD44 and CD43

(2019) Caroline Spertini et al.   Cancers

MIENTURNET: an interactive web tool for microRNA-target enrichment and network-based analysis

(2019) Valerio Licursi et al.   BMC BIOINFORMATICS

Ubiquitin ligases HUWE1 and NEDD4 cooperatively control signal-dependent PRC2-Ezh1α/β-mediated adaptive stress response pathway in skeletal muscle cells

(2019) Peng Liu et al.   Epigenetics & Chromatin

Enlarged spleen is associated with low neutrophil and platelet engraftment rates and poor survival after allogeneic stem cell transplantation in patients with acute myeloid leukemia and myelodysplastic syndrome

(2018) Yoshimitsu Shimomura et al.   ANNALS OF HEMATOLOGY

Exosomes in acute myeloid leukemia inhibit hematopoiesis

(2018) Michael Boyiadzis et al.   CURRENT OPINION IN HEMATOLOGY

Exosomes Induce Fibroblast Differentiation into Cancer-Associated Fibroblasts through TGFβ Signaling

(2018) Cassandra Ringuette Goulet et al.   MOLECULAR CANCER RESEARCH

Microfluidics-based super-resolution microscopy enables nanoscopic characterization of blood stem cell rolling

(2018) Karmen AbuZineh et al.   Science Advances

Proteomics study of human cord blood reticulocyte-derived exosomes

(2018) Míriam Díaz-Varela et al.   Scientific Reports

Exosomes derived from acute myeloid leukemia cells promote chemoresistance by enhancing glycolysis-mediated vascular remodeling

(2018) Bin Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

An improved pre-clinical patient-derived liquid xenograft mouse model for acute myeloid leukemia

(2017) Zhisheng Her et al.   Journal of Hematology & Oncology

Acute myeloid leukemia transforms the bone marrow niche into a leukemia-permissive microenvironment through exosome secretion

(2017) B Kumar et al.   LEUKEMIA

Circulating exosomes carrying an immunosuppressive cargo interfere with cellular immunotherapy in acute myeloid leukemia

(2017) Chang-Sook Hong et al.   Scientific Reports

An Analysis of Trafficking Receptors Shows that CD44 and P-Selectin Glycoprotein Ligand-1 Collectively Control the Migration of Activated Human T-Cells

(2017) Amal J. Ali et al.   Frontiers in Immunology

Roles of Rap1 signaling in tumor cell migration and invasion

(2017) Zhang Yi-Lei et al.   Cancer Biology & Medicine

Exosome-mediated microenvironment dysregulation in leukemia

(2016) Bijender Kumar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression

(2016) Esther Castellano et al.   Nature Communications

Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells

(2015) Euan Parnell et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Quantitative Characterization of E-selectin Interaction with Native CD44 and P-selectin Glycoprotein Ligand-1 (PSGL-1) Using a Real Time Immunoprecipitation-based Binding Assay

(2015) Dina B. AbuSamra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes

(2015) J Huan et al.   LEUKEMIA

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

DIANA-miRPath v3.0: deciphering microRNA function with experimental support

(2015) Ioannis S. Vlachos et al.   NUCLEIC ACIDS RESEARCH

Differential detergent sensitivity of extracellular vesicle subpopulations

(2015) Xabier Osteikoetxea et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Gel-aided sample preparation (GASP)-A simplified method for gel-assisted proteomic sample generation from protein extracts and intact cells

(2015) Roman Fischer et al.   PROTEOMICS

MicroRNA-26a prevents endothelial cell apoptosis by directly targeting TRPC6 in the setting of atherosclerosis

(2015) Yong Zhang et al.   Scientific Reports

Selectins and their ligands are required for homing and engraftment of BCR-ABL1+ leukemic stem cells in the bone marrow niche

(2014) D. S. Krause et al.   BLOOD

Notch1-induced T cell leukemia can be potentiated by microenvironmental cues in the spleen

(2014) Shihui Ma et al.   Journal of Hematology & Oncology

Isolation and Characterization of CD34+ Blast-Derived Exosomes in Acute Myeloid Leukemia

(2014) Chang Sook Hong et al.   PLoS One

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

(2013) Yanhua Tian et al.   BIOMATERIALS

Extracellular vesicles: structure, function, and potential clinical uses in renal diseases

(2013) F.T. Borges et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance

(2012) Ingrid G Winkler et al.   NATURE MEDICINE

Delivery of chemotherapeutic drugs in tumour cell-derived microparticles

(2012) Ke Tang et al.   Nature Communications

Analysis of glycoprotein E-selectin ligands on human and mouse marrow cells enriched for hematopoietic stem/progenitor cells

(2011) J. S. Merzaban et al.   BLOOD

Cytogenetic profile of patients with acute myeloid leukemia and central nervous system disease

(2011) Ferial Shihadeh et al.   CANCER

Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor- 1

(2011) M. J. Szczepanski et al.   HAEMATOLOGICA

Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences

(2011) Leonora Balaj et al.   Nature Communications

PI3K/AKT/mTOR Pathway in Angiogenesis

(2011) Jayashree Karar et al.   Frontiers in Molecular Neuroscience

The Role of Wnt Signaling in Physiological and Pathological Angiogenesis

(2010) Elisabetta Dejana   CIRCULATION RESEARCH

Exosomes: Extracellular organelles important in intercellular communication

(2010) Suresh Mathivanan et al.   Journal of Proteomics

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone

(2008) Robert Sackstein et al.   NATURE MEDICINE

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH