Article
Oncology
Bing Chen, Ya-Nan Deng, Xixi Wang, Zijing Xia, Yu He, Peng Zhang, Samina Ejaz Syed, Qiu Li, Shufang Liang
Summary: miR-26a is a key regulator of CRC tumorigenesis that enhances AKT1 transcription by improving the deacetylation modification of RREB1 in glycolysis, promoting CRC tumor growth.
Article
Immunology
Jin-ya Wang, Xiaoyan Dong, Zhiwei Yu, Lei Ge, Lu Lu, Ling Ding, Weihua Gan
Summary: The study demonstrated that borneol alleviated asthma in mice by downregulating miR-26a and miR-142-3p, which reduced CD4+ T cells infiltration, thereby attenuating disease progression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Juan-Juan Wang, Zi-Lin Chen, Ding-Ding Wang, Kun-Fang Wu, Wang-Bin Huang, Li-Qin Zhang
Summary: This study investigated the potential role and underlying mechanisms of linc00174 in the pathogenesis of diabetic retinopathy (DR). The results revealed that linc00174 was involved in the regulation of pyroptosis, possibly through the miR-26a-5p/PTEN/Akt signaling cascade. This research is of great significance for the development of potential therapeutic agents for DR treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Environmental Sciences
Huijie Chen, Peng Li, Ziqiang Shen, Jinliang Wang, Lei Diao
Summary: Se-Y was found to antagonize Cd-induced necroptosis in chicken kidneys by regulating the miR-26a-5p/PTEN/PI3K/AKT signaling pathway and HSPs, reducing oxidative stress and providing important protective effects.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Oncology
Hossein Sendi, Mostafa Yazdimamaghani, Mengying Hu, Nikhila Sultanpuram, Jie Wang, Amber S. Moody, Ellie McCabe, Jiajie Zhang, Amanda Graboski, Liantao Li, Juan D. Rojas, Paul A. Dayton, Leaf Huang, Andrew Z. Wang
Summary: Efficient delivery of miR-122 to hepatocytes using a nanomedicine-based formulation has the potential to prevent and treat colorectal cancer liver metastasis. Mechanistically, it downregulates key genes involved in metastatic and cancer inflammation pathways, increases CD8(+)/CD4(+) T-cell ratio, and decreases immunosuppressive cell infiltration, making the liver more conducive to antitumor immune response.
Article
Cell & Tissue Engineering
Yuyong Chen, Zhenming Tian, Lei He, Can Liu, Nangxiang Wang, Limin Rong, Bin Liu
Summary: Exosomes derived from miR-26a-modified MSC can promote axonal regeneration, improve neurogenesis, and attenuate glial scarring through the PTEN/AKT/mTOR signaling cascades in spinal cord injury.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Endocrinology & Metabolism
Liping Feng, Xianghui Liao
Summary: This study aims to investigate the effect of miR-193a-3p and its potential pathway in regulating bevacizumab resistance in colon cancer (CRC). The results reveal that miR-193a-3p enhances the resistance of CRC to bevacizumab through the regulation of the PTEN/AKT pathway.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Pathology
Hui Li, Jie Liu, Yiqin Lai, Sha Huang, Liang Zheng, Nanfen Fan
Summary: LINC01559 promotes CRC by sponging miR-1343-3p to modulate the PARP1/PTEN/AKT pathway, offering a new idea for CRC therapeutic treatment.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Environmental Sciences
Xin Xin, Lian Duan, Huimin Yang, Hang Yu, Yandong Bao, Dalin Jia, Nan Wu, Ying Qiao
Summary: miR-141-3p is significantly upregulated in cardiomyocytes of obese rats induced by a high-fat diet, but its role in myocardial lipotoxicity remains unclear. The study shows that miR-141-3p regulates saturated fatty acid-induced cardiomyocyte apoptosis through targeting PSEN1 and inhibiting the Notch1/PTEN/AKT pathway.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Medicine, Research & Experimental
Li Zeng, Hailun Jiang, Ghulam Md Ashraf, Jianghong Liu, Linlin Wang, Kaiyue Zhao, Mimin Liu, Zhuorong Li, Rui Liu
Summary: This study revealed the important role and mechanism of miR-148a-3p in Alzheimer's disease, which protects neuronal cells against tau hyperphosphorylation by regulating the p35/CDK5 and PTEN/p38 MAPK pathways. Moreover, a mutual regulatory link between miR-148a-3p and PTEN was confirmed through the promotion of transcription and expression, suggesting their essential contribution to AD pathology.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Biotechnology & Applied Microbiology
Qin Zhu, Xian Zhang, Hong-Yan Zai, Wei Jiang, Ke-Jing Zhang, Yu-Qiong He, Yu Hu
Summary: The study suggests that circSLC8A1 plays a role in breast cancer by regulating the miR-671 and PTEN/PI3k/Akt signaling pathways, leading to inhibition of tumor growth and metastasis.
Article
Oncology
Zhenzhen Sang, Shimin Dong, Pu Zhang, Yunxia Wei
Summary: The study demonstrated that miR-214 alleviated AKI in septic mice by inhibiting kidney autophagy levels. miR-214 further inhibited autophagy by silencing PTEN expression in the kidney tissues of septic mice. These results suggest that miR-214 ameliorated CLP-induced AKI by reducing oxidative stress and inhibiting autophagy through the regulation of the PTEN/AKT/mTOR pathway.
MOLECULAR MEDICINE REPORTS
(2021)
Review
Chemistry, Medicinal
Md Junaid, Yeasmin Akter, Syeda Samira Afrose, Mousumi Tania, Md Asaduzzaman Khan
Summary: AKT is a crucial enzyme in cancer development, and the natural compound TQ found in black cumin has shown potential anti-cancer activities by inhibiting AKT signaling pathways. Despite the development of numerous drugs targeting AKT, only a few have successfully passed clinical trials.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2021)
Article
Medical Laboratory Technology
Lina Wu, Xinpeng Zhang, Lin Luo, Xiaoying Li, Yong Liu, Xiaosong Qin
Summary: The study found that miR-106a, miR-19b, miR-17, and PTEN are involved in the pathogenesis of IMN and may serve as new biomarkers for the diagnosis of IMN.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Plant Sciences
Hong Wang, Qian Jiang, Li Kang, Ling Yuan, Guan Chen, Xiaoxue Cui, Luyao Wang, Ting Zhang, Lei Wang
Summary: The study found a positive correlation between plasma miR-21 levels and renal fibrosis scores. Rheum palmatum L. and Salvia miltiorhiza Bunge (RS) exert a protective effect against renal fibrosis through the miR-21/PTEN/AKT signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Editorial Material
Genetics & Heredity
Angeles Carlos-Reyes, Susana Romero-Garcia, Cesar Lopez-Camarillo, Guillermo Barreto, Heriberto Prado-Garcia
FRONTIERS IN GENETICS
(2023)
Review
Cell Biology
Euclides Jordan-Alejandre, Alma D. D. Campos-Parra, Dora Luz Castro-Lopez, Macrina Beatriz Silva-Cazares
Summary: Breast cancer is a common cancer in women, and metastasis often occurs in the bones, lungs, liver, and brain, leading to a high mortality rate. Researchers are exploring the use of miRNA molecules as biomarkers for the diagnosis and prediction of metastases. MiRNAs are small molecules that regulate gene expression and can be easily detected and replicated in the laboratory, making them a potential tool for diagnosis, prognosis, and treatment in breast cancer.
Review
Neurosciences
Hector Hernandez-Parra, Octavio Daniel Reyes-Hernandez, Gabriela Figueroa-Gonzalez, Manuel Gonzalez-Del Carmen, Maykel Gonzalez-Torres, Sheila I. Pena-Corona, Benjamin Floran, Hernan Cortes, Gerardo Leyva-Gomez
Summary: Various neurological symptoms, including stroke, ataxia, meningitis, encephalitis, and cognitive impairment, have been observed in COVID-19 patients infected with SARS-CoV-2. These symptoms are associated with the virus's ability to enter the Central Nervous System (CNS) and can lead to severe consequences. This review explores the mechanisms by which SARS-CoV-2 interacts with the blood-brain barrier (BBB) and discusses the implications for drug delivery to the CNS.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Oncology
Alma Jaqueline Heredia-Mendez, Gricelda Sanchez-Sanchez, Cesar Lopez-Camarillo
Summary: During the last century, 2D cell cultures have been commonly used to study cancer biology, drug discovery, genomics, and gene expression regulation. However, this approach has limitations in accurately reproducing the tumor microenvironment and cellular processes. To overcome these limitations, 3D cell cultures have been implemented to better mimic the biological and molecular features of tumors. This review discusses the application of different types of 3D cell culture models to characterize the epigenetic changes in cancer cells, particularly DNA methylation patterns, and the impact of microenvironmental factors on these changes.
Editorial Material
Cell Biology
Macrina B. Silva-Cazares, Carlos Perez-Plasencia, Cesar Lopez-Camarillo
Article
Oncology
Rafael Vazquez-Romo, Oliver Millan-Catalan, Erika Ruiz-Garcia, Antonio. D. D. Martinez-Gutierrez, Alberto Alvarado-Miranda, Alma. D. D. Campos-Parra, Cesar Lopez-Camarillo, Nadia Jacobo-Herrera, Eduardo Lopez-Urrutia, Mariano Guardado-Estrada, David Cantu de Leon, Carlos Perez-Plasencia
Summary: This study sequenced the DNA of 40 Mexican-mestizo metastatic breast cancer patients and identified 22 variants, including 9 novel ones. The study found a significantly high proportion of variations in ARID1A, and the presence of variants in ARID1A, BRCA1, BRCA2, or FANCA genes was associated with worse survival outcomes. The findings suggest routine screening for ARID1A and BRCA1/2 variants in Mexican-mestizo breast cancer patients.
FRONTIERS IN ONCOLOGY
(2023)
Review
Biology
Edgar Yebran Villegas-Vazquez, Laura Itzel Quintas-Granados, Hernan Cortes, Manuel Gonzalez-Del Carmen, Gerardo Leyva-Gomez, Miguel Rodriguez-Morales, Lilia Patricia Bustamante-Montes, Daniela Silva-Adaya, Carlos Perez-Plasencia, Nadia Jacobo-Herrera, Octavio Daniel Reyes-Hernandez, Gabriela Figueroa-Gonzalez
Summary: Lithium, an anti-cancer agent, shows potential in inducing apoptosis, autophagy, and inhibiting tumor growth. It also plays a role in tumor regulation and synergizes with standard cancer therapies. Additionally, lithium has neuroprotective effects and enhances anti-tumor activities in nano-sized form. However, its therapeutic activities depend on various factors. This review emphasizes the importance of repurposing lithium as a therapeutic agent and highlights its molecular mechanisms.
Article
Neurosciences
Andrea Corona-Trejo, Maria E. Gonsebatt, Cristina Trejo-Solis, Victoria Campos-Pena, Laura Itzel Quintas-Granados, Edgar Yebran Villegas-Vazquez, Octavio Daniel Reyes-Hernandez, Vicente Jesus Hernandez-Abad, Gabriela Figueroa-Gonzalez, Daniela Silva-Adaya
Summary: The transsulfuration pathway plays a crucial role in sulfur metabolism, producing various sulfur metabolites. These metabolites are involved in important physiological processes and control cellular functions. Disruptions in the transsulfuration pathway have been implicated in neurodegenerative diseases, including Parkinson's disease, affecting processes such as redox homeostasis and mitochondrial function.
REVIEWS IN THE NEUROSCIENCES
(2023)
Article
Oncology
Estefania Contreras-Sanzon, Angeles Carlos-Reyes, Monica Sierra-Martinez, Gustavo Acosta-Altamirano, Cesar Luna-Rivero, David Nunez-Corona, Alejandra Paola Garcia-Hernandez, Eloisa Ibarra-Sierra, Horacio Vidrio-Morgado, Maria Elizbeth Alvarez-Sanchez, Laurence A. Marchat, Cesar Lopez-Camarillo
Summary: This study evaluated the expression of VM-associated microRNAs in tumors of metastatic breast cancer patients and explored their potential therapeutic value in disease progression. It was found that certain microRNAs regulating VM and metastasis were downregulated in primary tumors of patients with metastatic disease, and these regulatory factors had predictive value in patient survival. Furthermore, in vitro experiments demonstrated that miR-145 mimics could inhibit the development of VM in metastatic breast cancer cells.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Engineering, Chemical
Lucero Evelia Acuna-Aguilar, Alain Salvador Conejo-Davila, Mario Miki-Yoshida, Olga N. Hernandez-de la Cruz, Gricelda Sanchez-Sanchez, Cesar Lopez-Camarillo, Joan Sebastian Salas-Leiva, Erasto Armando Zaragoza-Contreras, Reyna Reyes-Martinez, Erasmo Orrantia-Borunda
Summary: In this study, nanodiamonds functionalized with metformin (ND-MET) were synthesized and characterized. The cytotoxicity of ND-MET on breast and ovarian cancer cells was evaluated. The results showed that ND-MET exhibited significant toxicity towards cancer cells.
Article
Oncology
Mariana Avendano-Felix, Maribel Aguilar-Medina, Jose Geovanni Romero-Quintana, Alfredo Ayala-Ham, Adriana S. Beltran, Jose F. Olivares-Quintero, Cesar Lopez-Camarillo, Carlos Perez-Plasencia, Mercedes Bermudez, Erik Lizarraga-Verdugo, Jorge Lopez-Gutierrez, Guzman Sanchez-Schmitz, Rosalio Ramos-Payan
Summary: This study evaluated the role of SOX9 in colorectal cancer stem cells (CRC-CSCs). The results showed that SOX9 promotes the stemness properties of CRC-CSCs by regulating stem cell markers, increasing sphere formation, and maintaining CSCs surface markers. Therefore, SOX9 may serve as a potential therapeutic target for CRC stem cells.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Paola Zepeda-Enriquez, Macrina B. Silva-Cazares, Cesar Lopez-Camarillo
Summary: Circular RNAs play important roles in the development and progression of TNBC and have the potential to serve as prognostic biomarkers and novel therapeutic targets. In-depth understanding of circRNA biogenesis, functions, and their roles in metastasis and therapy responses could provide valuable guidance in advancing the treatment of TNBC.