High Intrinsic Oncogenic Potential in the Myc-Box-Deficient Hydra Myc3 Protein

A chromosome-scale epigenetic map of theHydragenome reveals conserved regulators of cell state

(2023) Jack F Cazet et al.   GENOME RESEARCH

The role of cnidarian developmental biology in unraveling axis formation and Wnt signaling

(2022) Thomas W. Holstein   DEVELOPMENTAL BIOLOGY

Computational insights into the differentiated binding affinities of Myc, Max, and Omomyc dimers to the E-boxes of DNA

(2022) Yuxin Dai et al.   JOURNAL OF MOLECULAR MODELING

Climbing cancer’s MYC mountain

(2022) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Whole-animal multiplexed single-cell RNA-seq reveals transcriptional shifts across Clytia medusa cell types

(2021) Tara Chari et al.   Science Advances

The brain acid‐soluble protein 1 (BASP1) interferes with the oncogenic capacity of MYC and its binding to calmodulin

(2020) Markus Hartl et al.   Molecular Oncology

Target gene-independent functions of MYC oncoproteins

(2020) Apoorva Baluapuri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Blocking Myc to Treat Cancer: Reflecting on Two Decades of Omomyc

(2020) Daniel Massó-Vallés et al.   Cells

Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy

(2019) Marie-Eve Beaulieu et al.   Science Translational Medicine

Differential regulation of myc homologs by Wnt/β‐Catenin signaling in the early metazoan Hydra

(2019) Markus Hartl et al.   FEBS Journal

Transgenesis in Hydra to characterize gene function and visualize cell behavior

(2019) Alexander Klimovich et al.   Nature Protocols

Stem cell differentiation trajectories in Hydra resolved at single-cell resolution

(2019) Stefan Siebert et al.   SCIENCE

Model systems for regeneration: Hydra

(2019) Matthias C. Vogg et al.   DEVELOPMENT

β-Catenin acts in a position-independent regeneration response in the simple eumetazoan Hydra

(2018) S. Gufler et al.   DEVELOPMENTAL BIOLOGY

A selective high affinity MYC-binding compound inhibits MYC:MAX interaction and MYC-dependent tumor cell proliferation

(2018) Alina Castell et al.   Scientific Reports

MYC Deregulation in Primary Human Cancers

(2017) Manpreet Kalkat et al.   Genes

W-IQ-TREE: a fast online phylogenetic tool for maximum likelihood analysis

(2016) Jana Trifinopoulos et al.   NUCLEIC ACIDS RESEARCH

A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity

(2016) Luca Fagnocchi et al.   Nature Communications

Calcium-dependent binding of Myc to calmodulin

(2016) Philipp Raffeiner et al.   Oncotarget

Taming of the beast: shaping Myc-dependent amplification

(2015) Elmar Wolf et al.   TRENDS IN CELL BIOLOGY

Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis

(2014) Daniela Annibali et al.   Nature Communications

An Overview of MYC and Its Interactome

(2014) M. Conacci-Sorrell et al.   Cold Spring Harbor Perspectives in Medicine

Hydra myc2, a unique pre-bilaterian member of the myc gene family, is activated in cell proliferation and gametogenesis

(2014) M. Hartl et al.   Biology Open

aLeaves facilitates on-demand exploration of metazoan gene family trees on MAFFT sequence alignment server with enhanced interactivity

(2013) Shigehiro Kuraku et al.   NUCLEIC ACIDS RESEARCH

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

Stemness in Hydra - a current perspective

(2012) Bert Hobmayer et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Hymyc1 Downregulation Promotes Stem Cell Proliferation in Hydra vulgaris

(2012) Alfredo Ambrosone et al.   PLoS One

Premetazoan Ancestry of the Myc–Max Network

(2011) Susan L. Young et al.   MOLECULAR BIOLOGY AND EVOLUTION

The Hydra polyp: Nothing but an active stem cell community

(2010) Thomas C. G. Bosch et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

The dynamic genome of Hydra

(2010) Jarrod A. Chapman et al.   NATURE

Stem cell-specific activation of an ancestral myc protooncogene with conserved basic functions in the early metazoan Hydra

(2010) M. Hartl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Axial Patterning in Hydra

(2009) H. R. Bode   Cold Spring Harbor Perspectives in Biology

Myc's broad reach

(2008) M. Eilers et al.   GENES & DEVELOPMENT

Modelling Myc inhibition as a cancer therapy

(2008) Laura Soucek et al.   NATURE