In SARS-CoV-2 delta variants, Spike-P681R and D950N promote membrane fusion, Spike-P681R enhances spike cleavage, but neither substitution affects pathogenicity in hamsters
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Title
In SARS-CoV-2 delta variants, Spike-P681R and D950N promote membrane fusion, Spike-P681R enhances spike cleavage, but neither substitution affects pathogenicity in hamsters
Authors
Keywords
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Journal
EBioMedicine
Volume 91, Issue -, Pages 104561
Publisher
Elsevier BV
Online
2023-04-10
DOI
10.1016/j.ebiom.2023.104561
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Note: Only part of the references are listed.- The accuracy of reverse genetics systems for SARS‐CoV‐2: Circular polymerase extension reaction versus bacterial artificial chromosome
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- (2022) Rahul K. Suryawanshi et al. NATURE
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- (2022) Yang Liu et al. Cell Reports
- Characterization of SARS-CoV-2 Omicron BA.4 and BA.5 isolates in rodents
- (2022) Ryuta Uraki et al. NATURE
- SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells
- (2021) Michihito Sasaki et al. PLoS Pathogens
- Engineering SARS-CoV-2 using a reverse genetic system
- (2021) Xuping Xie et al. Nature Protocols
- Generation of SARS-CoV-2 reporter replicon for high-throughput antiviral screening and testing
- (2021) Xi He et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Establishment of a reverse genetics system for SARS-CoV-2 using circular polymerase extension reaction
- (2021) Shiho Torii et al. Cell Reports
- The SARS-CoV-2 and other human coronavirus spike proteins are fine-tuned towards temperature and proteases of the human airways
- (2021) Manon Laporte et al. PLoS Pathogens
- The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets
- (2021) Thomas P. Peacock et al. Nature Microbiology
- SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity
- (2021) Chihiro Motozono et al. Cell Host & Microbe
- SARS-CoV-2 Delta VOC in Scotland: demographics, risk of hospital admission, and vaccine effectiveness
- (2021) Aziz Sheikh et al. LANCET
- Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study
- (2021) Katherine A Twohig et al. LANCET INFECTIOUS DISEASES
- Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization
- (2021) Delphine Planas et al. NATURE
- mRNA-1273 protects against SARS-CoV-2 beta infection in nonhuman primates
- (2021) Kizzmekia S. Corbett et al. NATURE IMMUNOLOGY
- SARS-CoV-2 variants of concern are emerging in India
- (2021) Jasdeep Singh et al. NATURE MEDICINE
- Characterization of a new SARS-CoV-2 variant that emerged in Brazil
- (2021) Masaki Imai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A versatile reverse genetics platform for SARS-CoV-2 and other positive-strand RNA viruses
- (2021) Alberto A. Amarilla et al. Nature Communications
- Emerging mutation patterns in SARS-CoV-2 variants
- (2021) David A. Ostrov et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation
- (2021) Akatsuki Saito et al. NATURE
- Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant
- (2021) Jun Zhang et al. SCIENCE
- Functional evaluation of the P681H mutation on the proteolytic activation of the SARS-CoV-2 variant B.1.1.7 (Alpha) spike
- (2021) Bailey Lubinski et al. iScience
- Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
- (2020) Chaolin Huang et al. LANCET
- A Novel Coronavirus from Patients with Pneumonia in China, 2019
- (2020) Na Zhu et al. NEW ENGLAND JOURNAL OF MEDICINE
- SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract
- (2020) Yixuan J. Hou et al. CELL
- SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
- (2020) Markus Hoffmann et al. CELL
- Cell entry mechanisms of SARS-CoV-2
- (2020) Jian Shang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells
- (2020) Shutoku Matsuyama et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Natural transmission of bat-like SARS-CoV-2PRRA variants in COVID-19 patients
- (2020) Yik Chun Wong et al. CLINICAL INFECTIOUS DISEASES
- SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology
- (2020) Natacha S. Ogando et al. JOURNAL OF GENERAL VIROLOGY
- Identification of common deletions in the spike protein of SARS-CoV-2
- (2020) Zhe Liu et al. JOURNAL OF VIROLOGY
- Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development
- (2020) Masaki Imai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein
- (2020) Andrew D. Davidson et al. Genome Medicine
- SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected hospitalized COVID-19 patients
- (2020) William B. Klimstra et al. JOURNAL OF GENERAL VIROLOGY
- Rescue of SARS-CoV-2 from a Single Bacterial Artificial Chromosome
- (2020) Chengjin Ye et al. mBio
- SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity
- (2020) Lizhou Zhang et al. Nature Communications
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