An SPNS1-dependent lysosomal lipid transport pathway that enables cell survival under choline limitation

Isotope tracing in health and disease

(2022) Wentao Dong et al.   CURRENT OPINION IN BIOTECHNOLOGY

CLN3 is required for the clearance of glycerophosphodiesters from lysosomes

(2022) Nouf N. Laqtom et al.   NATURE

Spns1 is a lysophospholipid transporter mediating lysosomal phospholipid salvage

(2022) Menglan He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals

(2022) Kayvon Pedram et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proton-driven alternating access in a spinster lipid transporter

(2022) Reza Dastvan et al.   Nature Communications

Development of an Autophagy-Based and Stemness-Correlated Prognostic Model for Hepatocellular Carcinoma Using Bulk and Single-Cell RNA-Sequencing

(2021) Shengwei Shen et al.   Frontiers in Cell and Developmental Biology

Analysis of Phospholipids, Lysophospholipids, and Their Linked Fatty Acyl Chains in Yellow Lupin Seeds (Lupinus luteus L.) by Liquid Chromatography and Tandem Mass Spectrometry

(2020) Cosima Damiana Calvano et al.   MOLECULES

Identification of an autophagy-related gene signature that can improve prognosis of hepatocellular carcinoma patients

(2020) Xingxing Huo et al.   BMC CANCER

How Lysosomes Sense, Integrate, and Cope with Stress

(2020) Paul Saftig et al.   TRENDS IN BIOCHEMICAL SCIENCES

De novo phosphatidylcholine synthesis is required for autophagosome membrane formation and maintenance during autophagy

(2019) Gabriela Andrejeva et al.   Autophagy

CRISPR-Cas9 screens identify regulators of antibody–drug conjugate toxicity

(2019) C. Kimberly Tsui et al.   Nature Chemical Biology

Crystal structure of a bacterial homolog to human lysosomal transporter, spinster

(2019) Fu Zhou et al.   Science Bulletin

Lysosomes as dynamic regulators of cell and organismal homeostasis

(2019) Andrea Ballabio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lysosomes: Signaling Hubs for Metabolic Sensing and Longevity

(2019) Marzia Savini et al.   TRENDS IN CELL BIOLOGY

EPT1 (selenoprotein I) is critical for the neural development and maintenance of plasmalogen in humans

(2018) Yasuhiro Horibata et al.   JOURNAL OF LIPID RESEARCH

Autophagy Sustains Pancreatic Cancer Growth through Both Cell-Autonomous and Nonautonomous Mechanisms

(2018) Annan Yang et al.   Cancer Discovery

Lysosomal storage diseases

(2018) Frances M. Platt et al.   Nature Reviews Disease Primers

Nutrient acquisition strategies of mammalian cells

(2017) Wilhelm Palm et al.   NATURE

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes

(2017) Monther Abu-Remaileh et al.   SCIENCE

Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens

(2017) David W. Morgens et al.   Nature Communications

Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression

(2017) Emelie Perland et al.   Open Biology

Autolysosome biogenesis and developmental senescence are regulated by both Spns1 and v-ATPase

(2016) Tomoyuki Sasaki et al.   Autophagy

Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes

(2016) David W Morgens et al.   NATURE BIOTECHNOLOGY

The I-TASSER Suite: protein structure and function prediction

(2015) Jianyi Yang et al.   NATURE METHODS

Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations

(2014) A. Yang et al.   Cancer Discovery

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

p53 status determines the role of autophagy in pancreatic tumour development

(2013) Mathias T. Rosenfeldt et al.   NATURE

Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol

(2009) Hyock Joo Kwon et al.   CELL

Principles of lysosomal membrane degradation

(2008) Heike Schulze et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Retromer

(2008) Juan S Bonifacino et al.   CURRENT OPINION IN CELL BIOLOGY

Thematic Review Series: Glycerolipids.Phosphatidylcholine and choline homeostasis

(2008) Zhaoyu Li et al.   JOURNAL OF LIPID RESEARCH

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

(2008) Emyr Lloyd-Evans et al.   NATURE MEDICINE