CRISPR-Cas9 screens identify regulators of antibody–drug conjugate toxicity
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Title
CRISPR-Cas9 screens identify regulators of antibody–drug conjugate toxicity
Authors
Keywords
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Journal
Nature Chemical Biology
Volume 15, Issue 10, Pages 949-958
Publisher
Springer Science and Business Media LLC
Online
2019-08-27
DOI
10.1038/s41589-019-0342-2
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Note: Only part of the references are listed.- FRET Reagent Reveals the Intracellular Processing of Peptide-Linked Antibody–Drug Conjugates
- (2018) Byoung-Chul Lee et al. BIOCONJUGATE CHEMISTRY
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- (2018) Guangmin Li et al. MOLECULAR CANCER THERAPEUTICS
- Antibody-drug conjugates (ADCs) for cancer therapy: Strategies, challenges, and successes
- (2018) Meghdad Abdollahpour-Alitappeh et al. JOURNAL OF CELLULAR PHYSIOLOGY
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- (2017) Kai Liu et al. JOURNAL OF CELL BIOLOGY
- LC–MS/MS method for the simultaneous determination of Lys-MCC-DM1, MCC-DM1 and DM1 as potential intracellular catabolites of the antibody-drug conjugate trastuzumab emtansine (T-DM1)
- (2017) Yazhong Liu et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Systematic Analysis of Human Cells Lacking ATG8 Proteins Uncovers Roles for GABARAPs and the CCZ1/MON1 Regulator C18orf8/RMC1 in Macroautophagic and Selective Autophagic Flux
- (2017) Laura Pontano Vaites et al. MOLECULAR AND CELLULAR BIOLOGY
- Caveolae-Mediated Endocytosis as a Novel Mechanism of Resistance to Trastuzumab Emtansine (T-DM1)
- (2017) Matthew Sung et al. MOLECULAR CANCER THERAPEUTICS
- Strategies and challenges for the next generation of antibody–drug conjugates
- (2017) Alain Beck et al. NATURE REVIEWS DRUG DISCOVERY
- Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens
- (2017) David W. Morgens et al. Nature Communications
- Sialyltransferase inhibition and recent advances
- (2016) Libo Wang et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Linkers Having a Crucial Role in Antibody–Drug Conjugates
- (2016) Jun Lu et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion
- (2016) Kai Liu et al. JOURNAL OF CELL BIOLOGY
- A simple LC/MRM–MS-based method to quantify free linker-payload in antibody-drug conjugate preparations
- (2016) Wesley Zmolek et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Effects of antibody, drug and linker on the preclinical and clinical toxicities of antibody-drug conjugates
- (2016) Heather Donaghy mAbs
- Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes
- (2016) David W Morgens et al. NATURE BIOTECHNOLOGY
- Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification
- (2016) Richard M Deans et al. Nature Chemical Biology
- Precision glycocalyx editing as a strategy for cancer immunotherapy
- (2016) Han Xiao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Genetic Screen Identifies a Critical Role for the WDR81-WDR91 Complex in the Trafficking and Degradation of Tetherin
- (2016) Radu Rapiteanu et al. TRAFFIC
- SLC46A3 Is Required to Transport Catabolites of Noncleavable Antibody Maytansine Conjugates from the Lysosome to the Cytoplasm
- (2015) K. J. Hamblett et al. CANCER RESEARCH
- The effect of the size of fluorescent dextran on its endocytic pathway
- (2015) Lei Li et al. CELL BIOLOGY INTERNATIONAL
- Sialic acids in cancer biology and immunity
- (2015) Oliver M T Pearce et al. GLYCOBIOLOGY
- The galectin lattice at a glance
- (2015) I. R. Nabi et al. JOURNAL OF CELL SCIENCE
- Tumor Cells Chronically Treated with a Trastuzumab-Maytansinoid Antibody-Drug Conjugate Develop Varied Resistance Mechanisms but Respond to Alternate Treatments
- (2015) F. Loganzo et al. MOLECULAR CANCER THERAPEUTICS
- Systemic Blockade of Sialylation in Mice with a Global Inhibitor of Sialyltransferases
- (2014) Matthew S. Macauley et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hydrazino-Pictet-Spengler Ligation as a Biocompatible Method for the Generation of Stable Protein Conjugates
- (2013) Paresh Agarwal et al. BIOCONJUGATE CHEMISTRY
- Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
- (2013) Lei S. Qi et al. CELL
- Implications of receptor-mediated endocytosis and intracellular trafficking dynamics in the development of antibody drug conjugates
- (2013) Michael Ritchie et al. mAbs
- Maturation of autophagosomes and endosomes: A key role for Rab7
- (2012) Juha M.T. Hyttinen et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome
- (2012) Cory D Rillahan et al. Nature Chemical Biology
- Site-specific chemical protein conjugation using genetically encoded aldehyde tags
- (2012) David Rabuka et al. Nature Protocols
- Antibodies to cell surface proteins redirect intracellular trafficking pathways
- (2011) Christine A. St. Pierre et al. EXPERIMENTAL AND MOLECULAR PATHOLOGY
- Identification of the Switch in Early-to-Late Endosome Transition
- (2010) Dmitry Poteryaev et al. CELL
- Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules
- (2010) M. Lopus et al. MOLECULAR CANCER THERAPEUTICS
- Antibody-Drug Conjugates for the Treatment of Non-Hodgkin's Lymphoma: Target and Linker-Drug Selection
- (2009) A. G. Polson et al. CANCER RESEARCH
- Targeting HER2-Positive Breast Cancer with Trastuzumab-DM1, an Antibody-Cytotoxic Drug Conjugate
- (2008) G. D. Lewis Phillips et al. CANCER RESEARCH
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