A novel chemical attack on Notch-mediated transcription by targeting the NACK ATPase

Pharmacological disruption of the Notch1 transcriptional complex inhibits tumor growth by selectively targeting cancer stem cells

(2021) Annamil Alvarez-Trotta et al.   CANCER RESEARCH

NACK and INTEGRATOR act coordinately to activate Notch-mediated transcription in tumorigenesis

(2021) Elena Shersher et al.   Cell Communication and Signaling

KLIFS: an overhaul after the first 5 years of supporting kinase research

(2020) Georgi K Kanev et al.   NUCLEIC ACIDS RESEARCH

Unexplored therapeutic opportunities in the human genome

(2018) Tudor I. Oprea et al.   NATURE REVIEWS DRUG DISCOVERY

Dimerization of the Pragmin Pseudo-Kinase Regulates Protein Tyrosine Phosphorylation

(2018) Céline Lecointre et al.   STRUCTURE

The Many Substrates of Presenilin/γ-Secretase

(2018) Annakaisa Haapasalo et al.   JOURNAL OF ALZHEIMERS DISEASE

Targeting Cancer Stemness in the Clinic: From Hype to Hope

(2018) Caner Saygin et al.   Cell Stem Cell

Notch Signaling in Development, Tissue Homeostasis, and Disease

(2017) Chris Siebel et al.   PHYSIOLOGICAL REVIEWS

Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders

(2017) David E. Puleo et al.   ACS Medicinal Chemistry Letters

Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association

(2017) Onisha Patel et al.   Nature Communications

The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis

(2016) L. Astudillo et al.   CANCER RESEARCH

Downregulation of Notch1 induces apoptosis and inhibits cell proliferation and metastasis in laryngeal squamous cell carcinoma

(2015) MENG-YUAN DAI et al.   ONCOLOGY REPORTS

YASARA View—molecular graphics for all devices—from smartphones to workstations

(2014) Elmar Krieger et al.   BIOINFORMATICS

NACK Is an Integral Component of the Notch Transcriptional Activation Complex and Is Critical for Development and Tumorigenesis

(2014) Kelly L. Weaver et al.   CANCER RESEARCH

Notch Signaling Drives Stemness and Tumorigenicity of Esophageal Adenocarcinoma

(2014) Z. Wang et al.   CANCER RESEARCH

Triple negative breast cancer initiating cell subsets differ in functional and molecular characteristics and in γ-secretase inhibitor drug responses

(2013) Diana J. Azzam et al.   EMBO Molecular Medicine

Targeting Notch signaling pathway in cancer: Clinical development advances and challenges

(2013) Naoko Takebe et al.   PHARMACOLOGY & THERAPEUTICS

Kinome-wide Activity Modeling from Diverse Public High-Quality Data Sets

(2012) Stephan C. Schürer et al.   Journal of Chemical Information and Modeling

NOTCH1 Nuclear Interactome Reveals Key Regulators of Its Transcriptional Activity and Oncogenic Function

(2012) Ahmad Yatim et al.   MOLECULAR CELL

Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells

(2011) K. L. VanDussen et al.   DEVELOPMENT

A Monoclonal Antibody against Human Notch1 Ligand-Binding Domain Depletes Subpopulation of Putative Breast Cancer Stem-like Cells

(2011) A. Sharma et al.   MOLECULAR CANCER THERAPEUTICS

Targeting cancer stem cells by inhibiting Wnt, Notch and Hedgehog pathways

(2010) Naoko Takebe et al.   Nature Reviews Clinical Oncology

Establishment of Patient-Derived Non-Small Cell Lung Cancer Xenografts as Models for the Identification of Predictive Biomarkers

(2008) I. Fichtner et al.   CLINICAL CANCER RESEARCH