Rapid restitution of contractile dysfunction by synthetic copolymers in dystrophin-deficient single live skeletal muscle fibers

Synthesis and Micellization of Bottlebrush Poloxamers

(2022) Joseph F. Hassler et al.   ACS Macro Letters

Postdevelopmental knockout of Orai1 improves muscle pathology in a mouse model of Duchenne muscular dystrophy

(2022) Maricela García-Castañeda et al.   JOURNAL OF GENERAL PHYSIOLOGY

Duchenne muscular dystrophy

(2021) Dongsheng Duan et al.   Nature Reviews Disease Primers

Abnormal Calcium Handling in Duchenne Muscular Dystrophy: Mechanisms and Potential Therapies

(2021) Satvik Mareedu et al.   Frontiers in Physiology

Murine models of Duchenne muscular dystrophy: is there a best model?

(2021) Kristy Swiderski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Gene Therapy for Duchenne Muscular Dystrophy

(2021) Nertiyan Elangkovan et al.   Journal of Neuromuscular Diseases

The ERG1a potassium channel increases basal intracellular calcium concentration and calpain activity in skeletal muscle cells

(2020) Clayton Whitmore et al.   Skeletal Muscle

Steroid Responsiveness in Duchenne Muscular Dystrophy – Predictive Value of Epigenetic Regulator Histone Deacetylase 2

(2020) Sunil Pradhan et al.   INDIAN JOURNAL OF PEDIATRICS

The Quest for the Prediction of Steroid Responsiveness in Duchenne Muscular Dystrophy

(2020) Renu Suthar et al.   INDIAN JOURNAL OF PEDIATRICS

Early myopathy in Duchenne muscular dystrophy is associated with elevated mitochondrial H 2 O 2 emission during impaired oxidative phosphorylation

(2019) Meghan C. Hughes et al.   Journal of Cachexia Sarcopenia and Muscle

AAV-based gene therapies for the muscular dystrophies

(2019) Julie M Crudele et al.   HUMAN MOLECULAR GENETICS

Micro-Dystrophin Gene Therapy Goes Systemic in Duchenne Muscular Dystrophy Patients

(2018) Dongsheng Duan   HUMAN GENE THERAPY

Muscle membrane integrity in Duchenne muscular dystrophy: recent advances in copolymer-based muscle membrane stabilizers

(2018) Evelyne M. Houang et al.   Skeletal Muscle

All-Atom Molecular Dynamics-Based Analysis of Membrane-Stabilizing Copolymer Interactions with Lipid Bilayers Probed under Constant Surface Tensions

(2017) Evelyne M. Houang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Chemical End Group Modified Diblock Copolymers Elucidate Anchor and Chain Mechanism of Membrane Stabilization

(2017) Evelyne M. Houang et al.   MOLECULAR PHARMACEUTICS

Anti-inflammatory drugs for Duchenne muscular dystrophy: focus on skeletal muscle-releasing factors

(2016) Yoshitsugu Aoki et al.   Drug Design Development and Therapy

Dystrophin restoration therapy improves both the reduced excitability and the force drop induced by lengthening contractions in dystrophic mdx skeletal muscle

(2016) Pauline Roy et al.   Skeletal Muscle

Membrane-stabilizing copolymers confer marked protection to dystrophic skeletal muscle in vivo

(2015) Evelyne M Houang et al.   Molecular Therapy-Methods & Clinical Development

Chronic Dosing with Membrane Sealant Poloxamer 188 NF Improves Respiratory Dysfunction in Dystrophic Mdx and Mdx/Utrophin-/- Mice

(2015) Bruce E. Markham et al.   PLoS One

Recovery of altered neuromuscular junction morphology and muscle function in mdx mice after injury

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Acute failure of action potential conduction inmdxmuscle reveals new mechanism of contraction-induced force loss

(2013) Jarrod A. Call et al.   JOURNAL OF PHYSIOLOGY-LONDON

Poloxamer 188 Protects Neurons against Ischemia/Reperfusion Injury through Preserving Integrity of Cell Membranes and Blood Brain Barrier

(2013) Jin-Hua Gu et al.   PLoS One

Effects ofin vivoinjury on the neuromuscular junction in healthy and dystrophic muscles

(2012) Stephen J.P. Pratt et al.   JOURNAL OF PHYSIOLOGY-LONDON

Interactions of PEO–PPO–PEO block copolymers with lipid membranes: a computational and experimental study linking membrane lysis with polymer structure

(2012) Selina Nawaz et al.   Soft Matter

Membrane Sealant Poloxamer P188 Protects Against Isoproterenol Induced Cardiomyopathy in Dystrophin Deficient Mice

(2011) Christopher F Spurney et al.   BMC Cardiovascular Disorders

Exacerbation of pathology by oxidative stress in respiratory and locomotor muscles with Duchenne muscular dystrophy

(2011) John M. Lawler   JOURNAL OF PHYSIOLOGY-LONDON

Diagnosis and management of Duchenne muscular dystrophy, part 1: diagnosis, and pharmacological and psychosocial management

(2009) Katharine Bushby et al.   LANCET NEUROLOGY

Effects of Poloxamer 188 on Phospholipid Monolayer Morphology: An Atomic Force Microscopy Study

(2009) Guohui Wu et al.   LANGMUIR

Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle

(2009) Andrew M Bellinger et al.   NATURE MEDICINE

Cardiac Consequences to Skeletal Muscle-Centric Therapeutics for Duchenne Muscular Dystrophy

(2009) DeWayne Townsend et al.   TRENDS IN CARDIOVASCULAR MEDICINE