Microfluidic platforms for DNA methylation analysis

Detection of DNA methyltransferase activity using allosteric molecular beacons

(2016) Weiting Zhang et al.   ANALYST

A novel label-free fluorescence strategy for methyltransferase activity assay based on dsDNA-templated copper nanoparticles coupled with an endonuclease-assisted signal transduction system

(2016) Q. Q. Lai et al.   ANALYST

High-Sensitivity and High-Efficiency Detection of DNA Hydroxymethylation in Genomic DNA by Multiplexing Electrochemical Biosensing

(2016) Shixing Chen et al.   ANALYTICAL CHEMISTRY

Efficient Enhancement of Electrochemiluminescence from Cadmium Sulfide Quantum Dots by Glucose Oxidase Mimicking Gold Nanoparticles for Highly Sensitive Assay of Methyltransferase Activity

(2016) Hong Zhou et al.   ANALYTICAL CHEMISTRY

Determination of DNA and RNA Methylation in Circulating Tumor Cells by Mass Spectrometry

(2016) Wei Huang et al.   ANALYTICAL CHEMISTRY

Rapid detection of Dam methyltransferase activity based on the exonuclease III-assisted isothermal amplification cycle

(2016) Xue Li et al.   Analytical Methods

A parallelized microfluidic DNA bisulfite conversion module for streamlined methylation analysis

(2016) Alejandro Stark et al.   BIOMEDICAL MICRODEVICES

Sensitive SERS detection of DNA methyltransferase by target triggering primer generation-based multiple signal amplification strategy

(2016) Ying Li et al.   BIOSENSORS & BIOELECTRONICS

Femtomolar level detection of RASSF1A tumor suppressor gene methylation by electrochemical nano-genosensor based on Fe 3 O 4 /TMC/Au nanocomposite and PT-modified electrode

(2016) Maryam Daneshpour et al.   BIOSENSORS & BIOELECTRONICS

DNA methyltransferase detection based on digestion triggering the combination of poly adenine DNA with gold nanoparticles

(2016) Pei Liu et al.   BIOSENSORS & BIOELECTRONICS

A dual amplification fluorescent strategy for sensitive detection of DNA methyltransferase activity based on strand displacement amplification and DNAzyme amplification

(2016) Wanling Cui et al.   BIOSENSORS & BIOELECTRONICS

Ultrasensitive determination of 5-methylcytosine and 5-hydroxymethylcytosine in genomic DNA by sheathless interfaced capillary electrophoresis–mass spectrometry

(2016) Fang Yuan et al.   CHEMICAL COMMUNICATIONS

Target-protected dumbbell molecular probe mediated cascade rolling circle amplification strategy for the sensitive assay of DNA methyltransferase activity

(2016) Haiyan Zhao et al.   CHEMICAL COMMUNICATIONS

Accurate and sensitive total genomic DNA methylation analysis from sub-nanogram input with embedded SERS nanotags

(2016) Yuling Wang et al.   CHEMICAL COMMUNICATIONS

Cell refractive index for cell biology and disease diagnosis: past, present and future

(2016) P. Y. Liu et al.   LAB ON A CHIP

Distance-based microfluidic quantitative detection methods for point-of-care testing

(2016) Tian Tian et al.   LAB ON A CHIP

Label-free monitoring of DNA methyltransferase activity based on terminal deoxynucleotidyl transferase using a thioflavin T probe

(2016) Changbei Ma et al.   MOLECULAR AND CELLULAR PROBES

DNA–gold nanoparticles network based electrochemical biosensors for DNA MTase activity

(2016) Lu Hong et al.   TALANTA

Quantification of 5-methyl-2'-deoxycytidine in the DNA

(2015) Małgorzata Giel-Pietraszuk et al.   ACTA BIOCHIMICA POLONICA

A sensitive strategy for the fluorescence detection of DNA methyltransferase activity based on the graphene oxide platform and T7 exonuclease-assisted cyclic signal amplification

(2015) Yefei Ma et al.   ANALYST

DNA methylation detection with end-to-end nanorod assembly-enhanced surface plasmon resonance

(2015) Xuemei Li et al.   ANALYST

Magnetic nanoparticles-cooperated fluorescence sensor for sensitive and accurate detection of DNA methyltransferase activity coupled with exonuclease III-assisted target recycling

(2015) Qingwang Xue et al.   ANALYST

MoS2 nanosheets as an effective fluorescence quencher for DNA methyltransferase activity detection

(2015) Huimin Deng et al.   ANALYST

A highly sensitive fluorescence assay for methyltransferase activity by exonuclease-aided signal amplification

(2015) Feng Tang et al.   ANALYST

G-quadruplex functionalized nano mesoporous silica for assay of the DNA methyltransferase activity

(2015) Pei Liu et al.   ANALYTICA CHIMICA ACTA

On-Chip Sequence-Specific Immunochemical Epigenomic Analysis Utilizing Outward-Turned Cytosine in a DNA Bulge with Handheld Surface Plasmon Resonance Equipment

(2015) Ryoji Kurita et al.   ANALYTICAL CHEMISTRY

Sensitive and Simultaneous Determination of 5-Methylcytosine and Its Oxidation Products in Genomic DNA by Chemical Derivatization Coupled with Liquid Chromatography-Tandem Mass Spectrometry Analysis

(2015) Yang Tang et al.   ANALYTICAL CHEMISTRY

Microfluidic Sample Preparation for Single Cell Analysis

(2015) Sanjin Hosic et al.   ANALYTICAL CHEMISTRY

Site-specific immunochemical methylation assessment from genome DNA utilizing a conformational difference between looped-out target and stacked-in nontarget methylcytosines

(2015) Ryoji Kurita et al.   BIOSENSORS & BIOELECTRONICS

Label-free electrochemical detection of methyltransferase activity and inhibitor screening based on endonuclease HpaII and the deposition of polyaniline

(2015) Linqun Zhang et al.   BIOSENSORS & BIOELECTRONICS

Nanosilver-based surface-enhanced Raman spectroscopic determination of DNA methyltransferase activity through real-time hybridization chain reaction

(2015) Ping Ping Hu et al.   BIOSENSORS & BIOELECTRONICS

DNA methyltransferase activity detection based on fluorescent silver nanocluster hairpin-shaped DNA probe with 5’-C-rich/G-rich-3’ tails

(2015) Wenting Liu et al.   BIOSENSORS & BIOELECTRONICS

Nanoplasmonic biosensor: Detection and amplification of dual bio-signatures of circulating tumor DNA

(2015) Anh H. Nguyen et al.   BIOSENSORS & BIOELECTRONICS

Highly sensitive fluorescence assay of DNA methyltransferase activity by methylation-sensitive cleavage-based primer generation exponential isothermal amplification-induced G-quadruplex formation

(2015) Qingwang Xue et al.   BIOSENSORS & BIOELECTRONICS

One-pot synthesis of GO/AgNPs/luminol composites with electrochemiluminescence activity for sensitive detection of DNA methyltransferase activity

(2015) Hui-Fang Zhao et al.   BIOSENSORS & BIOELECTRONICS

Ultrasensitive homogeneous electrochemical strategy for DNA methyltransferase activity assay based on autonomous exonuclease III-assisted isothermal cycling signal amplification

(2015) Wei Li et al.   BIOSENSORS & BIOELECTRONICS

Highly sensitive photoelectrochemical assay for DNA methyltransferase activity and inhibitor screening by exciton energy transfer coupled with enzyme cleavage biosensing strategy

(2015) Qingming Shen et al.   BIOSENSORS & BIOELECTRONICS

Label free detection of 5′hydroxymethylcytosine within CpG islands using optical sensors

(2015) Rasheeda M. Hawk et al.   BIOSENSORS & BIOELECTRONICS

Label free colorimetric and fluorimetric direct detection of methylated DNA based on silver nanoclusters for cancer early diagnosis

(2015) Mehdi Dadmehr et al.   BIOSENSORS & BIOELECTRONICS

Label-free molecular beacon-based quadratic isothermal exponential amplification: a simple and sensitive one-pot method to detect DNA methyltransferase activity

(2015) Qingwang Xue et al.   CHEMICAL COMMUNICATIONS

The determination of DNA methyltransferase activity by quenching of tris(2,2′-bipyridine)ruthenium electrogenerated chemiluminescence with ferrocene

(2015) Xiaoe Luo et al.   CHEMICAL COMMUNICATIONS

DNA-hybrid-gated functional mesoporous silica for sensitive DNA methyltransferase SERS detection

(2015) Xiaomeng Wang et al.   CHEMICAL COMMUNICATIONS

Sensitive detection of DNA methyltransferase activity by transcription-mediated duplex-specific nuclease-assisted cyclic signal amplification

(2015) Yan Zhang et al.   CHEMICAL COMMUNICATIONS

A label-free electrochemical strategy for highly sensitive methyltransferase activity assays

(2015) Jiawan Zhou et al.   CHEMICAL COMMUNICATIONS

Evaluation of DNA methyltransferase activity and inhibition via chiroplasmonic assemblies of gold nanoparticles

(2015) Yuanjian Liu et al.   CHEMICAL COMMUNICATIONS

Direct potential resolution and simultaneous detection of cytosine and 5-methylcytosine based on the construction of polypyrrole functionalized graphene nanowall interface

(2015) Po Wang et al.   ELECTROCHEMISTRY COMMUNICATIONS

Electrochemical biosensor for detection of DNA hydroxymethylation based on glycosylation and alkaline phosphatase catalytic signal amplification

(2015) Yunlei Zhou et al.   ELECTROCHIMICA ACTA

LoMA-B: a simple and versatile lab-on-a-chip system based on single-channel bisulfite conversion for DNA methylation analysis

(2015) Jaeyun Yoon et al.   LAB ON A CHIP

Research highlights: microfluidic-enabled single-cell epigenetics

(2015) Manjima Dhar et al.   LAB ON A CHIP

Microfluidic cell sorting: a review of the advances in the separation of cells from debulking to rare cell isolation

(2015) C. Wyatt Shields IV et al.   LAB ON A CHIP

Methyltransferase activity assay based on the use of exonuclease III, the hemin/G-quadruplex system and reduced graphene oxide on a gold electrode, and a study on enzyme inhibition

(2015) Zhiqing Yang et al.   MICROCHIMICA ACTA

Attomole quantification and global profile of RNA modifications: Epitranscriptome of human neural stem cells

(2015) Maria Basanta-Sanchez et al.   NUCLEIC ACIDS RESEARCH

Electrochemical immunosensor for N6-methyladenosine RNA modification detection

(2015) Huanshun Yin et al.   SENSORS AND ACTUATORS B-CHEMICAL

Electrochemical assessment of local cytosine methylation in genomic DNA on a nanocarbon film electrode fabricated by unbalanced magnetron sputtering

(2015) Hiroyuki Yanagisawa et al.   SENSORS AND ACTUATORS B-CHEMICAL

Electrochemical biosensor for DNA methyltransferase detection based on DpnI digestion triggering the formation of G-quadruplex DNAzymes

(2015) Pei Liu et al.   SENSORS AND ACTUATORS B-CHEMICAL

Highly sensitive homogeneous electrochemical assay for methyltransferase activity based on methylation-responsive exonuclease III-assisted signal amplification

(2015) Xiuzhong Wang et al.   SENSORS AND ACTUATORS B-CHEMICAL

Determination of DNA adenine methylation in genomes of mammals and plants by liquid chromatography/mass spectrometry

(2015) Wei Huang et al.   RSC Advances

Evaluating the sensitivity of hybridization-based epigenotyping using a methyl binding domain protein

(2014) Brandon W. Heimer et al.   ANALYST

Quantification of 5-methylcytosine, 5-hydroxymethylcytosine and 5-carboxylcytosine from the blood of cancer patients by an enzyme-based immunoassay

(2014) Basudev Chowdhury et al.   ANALYTICA CHIMICA ACTA

Rapid microfluidic solid-phase extraction system for hyper-methylated DNA enrichment and epigenetic analysis

(2014) Arpita De et al.   Biomicrofluidics

A sensitive microfluidic platform for a high throughput DNA methylation assay

(2014) Maria Ronen et al.   LAB ON A CHIP

High-Throughput Microfluidic Single-Cell Digital Polymerase Chain Reaction

(2013) A. K. White et al.   ANALYTICAL CHEMISTRY

Rapid screening of the heterogeneity of DNA methylation by single-strand conformation polymorphism and CE-LIF in the presence of electro-osmotic flow

(2013) Meng-Hsuan Yu et al.   ELECTROPHORESIS

Chemical Modification-Assisted Bisulfite Sequencing (CAB-Seq) for 5-Carboxylcytosine Detection in DNA

(2013) Xingyu Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electrochemical Assay for the Signal-On Detection of Human DNA Methyltransferase Activity

(2013) Natalie B. Muren et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solid phase nucleic acid extraction technique in a microfluidic chip using a novel non-chaotropic agent: dimethyl adipimidate

(2013) Yong Shin et al.   LAB ON A CHIP

A DNA methylation assay for detection of ovarian cancer cells using a HpaII/MspI digestion-based PCR assay in an integrated microfluidic system

(2013) Chih-Hung Wang et al.   Microfluidics and Nanofluidics

Tet-mediated covalent labelling of 5-methylcytosine for its genome-wide detection and sequencing

(2013) Liang Zhang et al.   Nature Communications

A simple colorimetric detection of DNA methylation

(2012) Chenchen Ge et al.   ANALYST

Signal Amplification of Graphene Oxide Combining with Restriction Endonuclease for Site-Specific Determination of DNA Methylation and Assay of Methyltransferase Activity

(2012) Wen Li et al.   ANALYTICAL CHEMISTRY

DNA Methylation Analysis Triggered by Bulge Specific Immuno-Recognition

(2012) Ryoji Kurita et al.   ANALYTICAL CHEMISTRY

Highly sensitive fluorescence assay of DNA methyltransferase activity via methylation-sensitive cleavage coupled with nicking enzyme-assisted signalamplification

(2012) Yongxi Zhao et al.   BIOSENSORS & BIOELECTRONICS

A sensitive electrochemical biosensor for detection of DNA methyltransferase activity by combining DNA methylation-sensitive cleavage and terminal transferase-mediated extension

(2012) Huiwang Wu et al.   CHEMICAL COMMUNICATIONS

Environmental epigenetics: prospects for studying epigenetic mediation of exposure–response relationships

(2012) Victoria K. Cortessis et al.   HUMAN GENETICS

Determination of the heterogeneity of DNA methylation by combined bisulfite restriction analysis and capillary electrophoresis with laser-induced fluorescence

(2012) Hua-Chien Chen et al.   JOURNAL OF CHROMATOGRAPHY A

Microfluidic designs and techniques using lab-on-a-chip devices for pathogen detection for point-of-care diagnostics

(2012) Amir M. Foudeh et al.   LAB ON A CHIP

Real-time analysis and selection of methylated DNA by fluorescence-activated single molecule sorting in a nanofluidic channel

(2012) B. R. Cipriany et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of methyl-DNA immunoprecipitation (MeDIP) and methyl-CpG binding domain (MBD) protein capture for genome-wide DNA methylation analysis reveal CpG sequence coverage bias

(2011) Shalima S. Nair et al.   Epigenetics

Environmental chemical exposures and human epigenetics

(2011) Lifang Hou et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

An immunochemical method for detection and analysis of changes in methylome

(2011) Deepti D. Deobagkar et al.   METHODS

Novel DNA binding domain-based assays for detection of methylated and nonmethylated DNA

(2011) Luis G Acevedo et al.   Epigenomics

Label-free cell separation and sorting in microfluidic systems

(2010) Daniel R. Gossett et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Fluorescently Imaged Particle Counting Immunoassay for Sensitive Detection of DNA Modifications

(2010) Zhixin Wang et al.   ANALYTICAL CHEMISTRY

Direct DNA Methylation Profiling Using Methyl Binding Domain Proteins

(2010) Yinni Yu et al.   ANALYTICAL CHEMISTRY

Single Molecule Epigenetic Analysis in a Nanofluidic Channel

(2010) Benjamin R. Cipriany et al.   ANALYTICAL CHEMISTRY

A novel method to assess the full genome methylation profile using monoclonal antibody combined with the high throughput based microarray approach

(2010) Ashwin Kelkar et al.   Epigenetics

Overview of single-cell analyses: microdevices and applications

(2010) Sara Lindström et al.   LAB ON A CHIP

Lab-on-a-chip based immunosensor principles and technologies for the detection of cardiac biomarkers: a review

(2010) Mazher-Iqbal Mohammed et al.   LAB ON A CHIP

DNA methylation profiling using bisulfite-based epityping of pooled genomic DNA

(2010) Sophia J. Docherty et al.   METHODS

Quantitative comparison of genome-wide DNA methylation mapping technologies

(2010) Christoph Bock et al.   NATURE BIOTECHNOLOGY

Targets and dynamics of promoter DNA methylation during early mouse development

(2010) Julie Borgel et al.   NATURE GENETICS

Single cell analysis: the new frontier in ‘omics’

(2010) Daojing Wang et al.   TRENDS IN BIOTECHNOLOGY

Fluorescence Polarization Combined Capillary Electrophoresis Immunoassay for the Sensitive Detection of Genomic DNA Methylation

(2009) Xiaoli Wang et al.   ANALYTICAL CHEMISTRY

Novel Method to Detect DNA Methylation Using Gold Nanoparticles Coupled with Enzyme-Linkage Reactions

(2009) Tao Liu et al.   ANALYTICAL CHEMISTRY

PCR-Based Methods for Detecting Single-Locus DNA Methylation Biomarkers in Cancer Diagnostics, Prognostics, and Response to Treatment

(2009) L. S. Kristensen et al.   CLINICAL CHEMISTRY

Nucleic acid extraction techniques and application to the microchip

(2009) Carol W. Price et al.   LAB ON A CHIP

MBD-isolated Genome Sequencing provides a high-throughput and comprehensive survey of DNA methylation in the human genome

(2009) David Serre et al.   NUCLEIC ACIDS RESEARCH

Innovations in optical microfluidic technologies for point-of-care diagnostics

(2008) Frank B. Myers et al.   LAB ON A CHIP

Towards non- and minimally instrumented, microfluidics-based diagnostic devices

(2008) Bernhard Weigl et al.   LAB ON A CHIP

An in vitro microfluidic approach to generating protein-interaction networks

(2008) Doron Gerber et al.   NATURE METHODS

The development of microgels/nanogels for drug delivery applications

(2008) Jung Kwon Oh et al.   PROGRESS IN POLYMER SCIENCE

Selective Detection of 5-Methylcytosine Sites in DNA

(2007) Sébastian Bareyt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

MEMS-based micropumps in drug delivery and biomedical applications

(2007) A. Nisar et al.   SENSORS AND ACTUATORS B-CHEMICAL