Cationic amphiphilic antihistamines inhibit STAT3 via Ca2+-dependent lysosomal H+ efflux

Improved survival in several cancers with use of H1-antihistamines desloratadine and loratadine

(2021) Ildikó Fritz et al.   Translational Oncology

Saga of Mcl-1: regulation from transcription to degradation

(2020) Viacheslav V. Senichkin et al.   CELL DEATH AND DIFFERENTIATION

Desloratadine and loratadine stand out among common H1-antihistamines for association with improved breast cancer survival

(2020) Ildikó Fritz et al.   ACTA ONCOLOGICA

Lysosomes in glioblastoma: pump up the volume

(2020) Kathryn A Jacobs et al.   CELL CYCLE

Cationic amphiphilic drugs induce elevation in lysoglycerophospholipid levels and cell death in leukemia cells

(2020) Inger Ødum Nielsen et al.   Metabolomics

Lysosome as a Central Hub for Rewiring PH Homeostasis in Tumors

(2020) Ran Chen et al.   Cancers

Cell death induced by cationic amphiphilic drugs depends on lysosomal Ca2+ release and cyclic AMP

(2019) Atul Anand et al.   MOLECULAR CANCER THERAPEUTICS

Nutrient regulation of mTORC1 at a glance

(2019) Kendall J. Condon et al.   JOURNAL OF CELL SCIENCE

Antihistamines and ovarian cancer survival: nationwide cohort study and in vitro cell viability assay

(2019) Freija Verdoodt et al.   JNCI-Journal of the National Cancer Institute

Statistical determination of synergy based on Bliss definition of drugs independence

(2019) Eugene Demidenko et al.   PLoS One

The hidden potential of lysosomal ion channels: A new era of oncogenes

(2018) Andra M Sterea et al.   CELL CALCIUM

SypHer3s: a genetically encoded fluorescent ratiometric probe with enhanced brightness and an improved dynamic range

(2018) Y. G. Ermakova et al.   CHEMICAL COMMUNICATIONS

L61H46 shows potent efficacy against human pancreatic cancer through inhibiting STAT3 pathway

(2018) Encheng Bai et al.   Cancer Management and Research

STAT3 associates with vacuolar H+-ATPase and regulates cytosolic and lysosomal pH

(2018) Bin Liu et al.   CELL RESEARCH

V-ATPase (Vacuolar ATPase) Activity Required for ABCA1 (ATP-Binding Cassette Protein A1)-Mediated Cholesterol Efflux

(2018) Shuhui Wang Lorkowski et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lysosomal Ion Channels as Decoders of Cellular Signals

(2018) Ping Li et al.   TRENDS IN BIOCHEMICAL SCIENCES

Drugging the addict: non‐oncogene addiction as a target for cancer therapy

(2016) Remco Nagel et al.   EMBO REPORTS

The position of lysosomes within the cell determines their luminal pH

(2016) Danielle E. Johnson et al.   JOURNAL OF CELL BIOLOGY

The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins

(2016) Andrew D. Rouillard et al.   Database-The Journal of Biological Databases and Curation

Repurposing Cationic Amphiphilic Antihistamines for Cancer Treatment

(2016) Anne-Marie Ellegaard et al.   EBioMedicine

Lysosomal Physiology

(2015) Haoxing Xu et al.   Annual Review of Physiology

Sensitive detection of lysosomal membrane permeabilization by lysosomal galectin puncta assay

(2015) Sonja Aits et al.   Autophagy

Dual Targeting of the Autophagic Regulatory Circuitry in Gliomas with Repurposed Drugs Elicits Cell-Lethal Autophagy and Therapeutic Benefit

(2015) Ksenya Shchors et al.   CANCER CELL

Penfluridol: An Antipsychotic Agent Suppresses Metastatic Tumor Growth in Triple-Negative Breast Cancer by Inhibiting Integrin Signaling Axis

(2015) A. Ranjan et al.   CANCER RESEARCH

Lung Adenocarcinomas and Lung Cancer Cell Lines Show Association of MMP-1 Expression With STAT3 Activation

(2015) Alexander Schütz et al.   Translational Oncology

Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation

(2014) Marie Stampe Ostenfeld et al.   Autophagy

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The voltage-gated sodium channel TPC1 confers endolysosomal excitability

(2014) Chunlei Cang et al.   Nature Chemical Biology

Genetically-Encoded Yellow Fluorescent cAMP Indicator with an Expanded Dynamic Range for Dual-Color Imaging

(2014) Haruki Odaka et al.   PLoS One

STAT3 Target Genes Relevant to Human Cancers

(2014) Richard Carpenter et al.   Cancers

Transformation-Associated Changes in Sphingolipid Metabolism Sensitize Cells to Lysosomal Cell Death Induced by Inhibitors of Acid Sphingomyelinase

(2013) Nikolaj H.T. Petersen et al.   CANCER CELL

Ultrasensitive fluorescent proteins for imaging neuronal activity

(2013) Tsai-Wen Chen et al.   NATURE

Tagging of Genomic STAT3 and STAT1 with Fluorescent Proteins and Insertion of a Luciferase Reporter in the Cyclin D1 Gene Provides a Modified A549 Cell Line to Screen for Selective STAT3 Inhibitors

(2013) Andrey Samsonov et al.   PLoS One

A Drug Repositioning Approach Identifies Tricyclic Antidepressants as Inhibitors of Small Cell Lung Cancer and Other Neuroendocrine Tumors

(2013) N. S. Jahchan et al.   Cancer Discovery

Structure-Activity Analysis of Niclosamide Reveals Potential Role for Cytoplasmic pH in Control of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling

(2012) Bruno D. Fonseca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors

(2012) Mahadeo A. Sukhai et al.   JOURNAL OF CLINICAL INVESTIGATION

ErbB2-Driven Breast Cancer Cell Invasion Depends on a Complex Signaling Network Activating Myeloid Zinc Finger-1-Dependent Cathepsin B Expression

(2012) Bo Rafn et al.   MOLECULAR CELL

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Niclosamide Is a Proton Carrier and Targets Acidic Endosomes with Broad Antiviral Effects

(2012) Andreas Jurgeit et al.   PLoS Pathogens

Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): A Novel Pharmacological Group of Drugs with Broad Clinical Applications

(2010) Johannes Kornhuber et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

(2009) D. J. Gough et al.   SCIENCE

Function of Mitochondrial Stat3 in Cellular Respiration

(2009) J. Wegrzyn et al.   SCIENCE

Function, structure and regulation of the vacuolar (H+)-ATPases

(2008) Kevin C. Jefferies et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Quantitative modeling of selective lysosomal targeting for drug design

(2008) Stefan Trapp et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology