Saga of Mcl-1: regulation from transcription to degradation

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

(2019) Rumani Singh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Elevated H3K27me3 levels sensitize osteosarcoma to cisplatin

(2019) Chao He et al.   Clinical Epigenetics

Circular RNA circHIPK3 promotes cell proliferation and invasion of prostate cancer by sponging miR-193a-3p and regulating MCL1 expression

(2019) Dong Chen et al.   Cancer Management and Research

Myeloid cell leukemia-1 dependence in acute myeloid leukemia: a novel approach to patient therapy

(2019) Tapan Mahendra Kadia et al.   Oncotarget

MGMT-activated DUB3 stabilizes MCL1 and drives chemoresistance in ovarian cancer

(2019) Xiaowei Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent advances in the development of Mcl-1 inhibitors for cancer therapy

(2019) Alexander W. Hird et al.   PHARMACOLOGY & THERAPEUTICS

CircOMA1 mediated miR-145-5p suppresses tumor growth of nonfunctioning pituitary adenomas by targeting TPT1

(2019) Qiu Du et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

(2019) Mohamed Elgendy et al.   CANCER CELL

JOSD1 inhibits mitochondrial apoptotic signalling to drive acquired chemoresistance in gynaecological cancer by stabilizing MCL1

(2019) Xiaowei Wu et al.   CELL DEATH AND DIFFERENTIATION

Molecular Comprehension of Mcl-1: From Gene Structure to Cancer Therapy

(2019) Viacheslav V. Senichkin et al.   TRENDS IN CELL BIOLOGY

LncRNA ANRIL protects against oxygen and glucose deprivation (OGD)-induced injury in PC-12 cells: potential role in ischaemic stroke

(2019) Bin Liu et al.   Artificial Cells Nanomedicine and Biotechnology

Long non‐coding RNA MYOSLID functions as a competing endogenous RNA to regulate MCL‐1 expression by sponging miR‐29c‐3p in gastric cancer

(2019) Yuying Han et al.   CELL PROLIFERATION

Modulation of Mcl-1 transcription by serum deprivation sensitizes cancer cells to cisplatin

(2018) Viacheslav V. Senichkin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Long noncoding RNA SNHG12 mediates doxorubicin resistance of osteosarcoma via miR-320a/MCL1 axis

(2018) Binghua Zhou et al.   BIOMEDICINE & PHARMACOTHERAPY

LINC00152 down-regulated miR-193a-3p to enhance MCL1 expression and promote gastric cancer cells proliferation

(2018) Yong Huang et al.   BIOSCIENCE REPORTS

Mcl-1 phosphorylation without degradation mediates sensitivity to HDAC inhibitors by liberating BH3-only proteins

(2018) Jingshan Tong et al.   CANCER RESEARCH

Atypical APC/C‐dependent degradation of Mcl‐1 provides an apoptotic timer during mitotic arrest

(2018) Lindsey A Allan et al.   EMBO JOURNAL

Post-Transcriptional Regulation of Anti-Apoptotic BCL2 Family Members

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MCL-1 is a prognostic indicator and drug target in breast cancer

(2018) Kirsteen J. Campbell et al.   Cell Death & Disease

Long noncoding RNA LINC00152 promotes cell proliferation through competitively binding endogenous miR-125b with MCL-1 by regulating mitochondrial apoptosis pathways in ovarian cancer

(2018) Puxiang Chen et al.   Cancer Medicine

The suppressive effect of arsenic trioxide on TET2-FOXP3-Lyn-Akt axis-modulated MCL1 expression induces apoptosis in human leukemia cells

(2018) Ying-Jung Chen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines

(2018) Delphine Merino et al.   CANCER CELL

FBXW7 modulates malignant potential and cisplatin-induced apoptosis in cholangiocarcinoma through NOTCH1 and MCL1

(2018) Akiko Mori et al.   CANCER SCIENCE

By reducing global mRNA translation in several ways, 2-deoxyglucose lowers MCL-1 protein and sensitizes hemopoietic tumor cells to BH3 mimetic ABT737

(2018) Maximilien Tailler et al.   CELL DEATH AND DIFFERENTIATION

LncRNA PMS2L2 protects ATDC5 chondrocytes against lipopolysaccharide-induced inflammatory injury by sponging miR-203

(2018) Xiaoyan Li et al.   LIFE SCIENCES

Novel regulatory roles of Mff and Drp1 in E3 ubiquitin ligase MARCH5–dependent degradation of MiD49 and Mcl1 and control of mitochondrial dynamics

(2017) Edward Cherok et al.   MOLECULAR BIOLOGY OF THE CELL

Multifaceted Roles of GSK-3 in Cancer and Autophagy-Related Diseases

(2017) Romina Mancinelli et al.   Oxidative Medicine and Cellular Longevity

A pathology atlas of the human cancer transcriptome

(2017) Mathias Uhlen et al.   SCIENCE

Post-translational Modification of Caspases: The Other Side of Apoptosis Regulation

(2017) Alexey V. Zamaraev et al.   TRENDS IN CELL BIOLOGY

Inhibition of EZH2 triggers the tumor suppressive miR-29b network in multiple myeloma

(2017) Maria Angelica Stamato et al.   Oncotarget

Carfilzomib Triggers Cell Death in Chronic Lymphocytic Leukemia by Inducing Proapoptotic and Endoplasmic Reticulum Stress Responses

(2016) B. Lamothe et al.   CLINICAL CANCER RESEARCH

Binding of Released Bim to Mcl-1 is a Mechanism of Intrinsic Resistance to ABT-199 which can be Overcome by Combination with Daunorubicin or Cytarabine in AML Cells

(2016) X. Niu et al.   CLINICAL CANCER RESEARCH

HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation

(2016) Kevin B Myant et al.   EMBO Molecular Medicine

The lncRNA MALAT1 functions as a competing endogenous RNA to regulate MCL-1 expression by sponging miR-363-3p in gallbladder cancer

(2016) Shou-Hua Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Survival control of malignant lymphocytes by anti-apoptotic MCL-1

(2016) Y Fernández-Marrero et al.   LEUKEMIA

COSMIC: somatic cancer genetics at high-resolution

(2016) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation

(2016) J Tong et al.   ONCOGENE

Efficacy and Biological Correlates of Response in a Phase II Study of Venetoclax Monotherapy in Patients with Acute Myelogenous Leukemia

(2016) M. Konopleva et al.   Cancer Discovery

Inhibition of MARCH5 ubiquitin ligase abrogates MCL1-dependent resistance to BH3 mimetics via NOXA

(2016) Aishwarya Subramanian et al.   Oncotarget

Mcl-1 dynamics influence mitotic slippage and death in mitosis

(2016) Olivia Sloss et al.   Oncotarget

Reduced occurrence of tumor flare with flavopiridol followed by combined flavopiridol and lenalidomide in patients with relapsed chronic lymphocytic leukemia (CLL)

(2015) Kami Maddocks et al.   AMERICAN JOURNAL OF HEMATOLOGY

Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies

(2015) L. F. Peterson et al.   BLOOD

Sorafenib Inhibition of Mcl-1 Accelerates ATRA-Induced Apoptosis in Differentiation-Responsive AML Cells

(2015) R. Wang et al.   CLINICAL CANCER RESEARCH

Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family members

(2015) Joseph T. Opferman   FEBS Journal

A phase 1 study with dose expansion of the CDK inhibitor dinaciclib (SCH 727965) in combination with epirubicin in patients with metastatic triple negative breast cancer

(2015) Zahi Mitri et al.   INVESTIGATIONAL NEW DRUGS

Inhibition of IRAK1/4 sensitizes T cell acute lymphoblastic leukemia to chemotherapies

(2015) Zhaoyang Li et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR Complex 2 Stabilizes Mcl-1 Protein by Suppressing Its Glycogen Synthase Kinase 3-Dependent and SCF-FBXW7-Mediated Degradation

(2015) Junghui Koo et al.   MOLECULAR AND CELLULAR BIOLOGY

Apoptosis Triggers Specific, Rapid, and Global mRNA Decay with 3′ Uridylated Intermediates Degraded by DIS3L2

(2015) Marshall P. Thomas et al.   Cell Reports

Sorafenib Sensitizes Glioma Cells to the BH3 Mimetic ABT-737 by Targeting MCL1 in a STAT3-Dependent Manner

(2015) Irina Kiprianova et al.   NEOPLASIA

Role of Ku70 in deubiquitination of Mcl-1 and suppression of apoptosis

(2014) B Wang et al.   CELL DEATH AND DIFFERENTIATION

PINK1 Triggers Autocatalytic Activation of Parkin to Specify Cell Fate Decisions

(2014) Conggang Zhang et al.   CURRENT BIOLOGY

Estrogen Regulation of Anti-Apoptotic Bcl-2 Family Member Mcl-1 Expression in Breast Cancer Cells

(2014) Jennifer L. Schacter et al.   PLoS One

Parkin Sensitizes toward Apoptosis Induced by Mitochondrial Depolarization through Promoting Degradation of Mcl-1

(2014) Richard G. Carroll et al.   Cell Reports

HTLV-1 Tax Stabilizes MCL-1 via TRAF6-Dependent K63-Linked Polyubiquitination to Promote Cell Survival and Transformation

(2014) Young Bong Choi et al.   PLoS Pathogens

Mcl-1 Ubiquitination: Unique Regulation of an Essential Survival Protein

(2014) Barbara Mojsa et al.   Cells

Targeting Mcl-1 for multiple myeloma (MM) therapy: Drug-induced generation of Mcl-1 fragment Mcl-1128–350 triggers MM cell death via c-Jun upregulation

(2013) Fengjuan Fan et al.   CANCER LETTERS

Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction

(2013) X. Wang et al.   GENES & DEVELOPMENT

Glycolysis Inhibition Sensitizes Non-Small Cell Lung Cancer with T790M Mutation to Irreversible EGFR Inhibitors via Translational Suppression of Mcl-1 by AMPK Activation

(2013) S. M. Kim et al.   MOLECULAR CANCER THERAPEUTICS

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor

(2013) T M Becker et al.   ONCOGENE

Mcl-1 Phosphorylation Defines ABT-737 Resistance That Can Be Overcome by Increased NOXA Expression in Leukemic B cells

(2012) S. Mazumder et al.   CANCER RESEARCH

MYC directs transcription of MCL1 and eIF4E genes to control sensitivity of gastric cancer cells toward HDAC inhibitors

(2012) Wajana L. Labisso et al.   CELL CYCLE

Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons

(2012) M M Magiera et al.   CELL DEATH AND DIFFERENTIATION

Selectively targeting Mcl-1 for the treatment of acute myelogenous leukemia and solid tumors

(2012) G. J. Gores et al.   GENES & DEVELOPMENT

The E3 ubiquitin ligase Mule acts through the ATM–p53 axis to maintain B lymphocyte homeostasis

(2012) Zhenyue Hao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mcl-1 and FBW7 Control a Dominant Survival Pathway Underlying HDAC and Bcl-2 Inhibitor Synergy in Squamous Cell Carcinoma

(2012) Lei He et al.   Cancer Discovery

Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1/USP9X interaction

(2011) Patricia Gomez-Bougie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of ATF4 mediates unwanted Mcl-1 accumulation by proteasome inhibition

(2011) J. Hu et al.   BLOOD

Phase 1 and pharmacokinetic study of bolus-infusion flavopiridol followed by cytosine arabinoside and mitoxantrone for acute leukemias

(2011) J. E. Karp et al.   BLOOD

Navitoclax (ABT-263) Accelerates Apoptosis during Drug-Induced Mitotic Arrest by Antagonizing Bcl-xL

(2011) J. Shi et al.   CANCER RESEARCH

Molecular Mechanisms of Long Noncoding RNAs

(2011) Kevin C. Wang et al.   MOLECULAR CELL

SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

(2011) Hiroyuki Inuzuka et al.   NATURE

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

(2011) Ingrid E. Wertz et al.   NATURE

ELK4 neutralization sensitizes glioblastoma to apoptosis through downregulation of the anti-apoptotic protein Mcl-1

(2011) Bryan W. Day et al.   NEURO-ONCOLOGY

Epidermal growth factor regulates Mcl-1 expression through the MAPK-Elk-1 signalling pathway contributing to cell survival in breast cancer

(2011) E P Booy et al.   ONCOGENE

Ets-1 mediates upregulation of Mcl-1 downstream of XBP-1 in human melanoma cells upon ER stress

(2011) L Dong et al.   ONCOGENE

Mechanism of hypoxia-inducible factor 1α-mediated Mcl1 regulation in Helicobacter pylori-infected human gastric epithelium

(2010) Asima Bhattacharyya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Phosphorylation of Mcl-1 by CDK1–cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest

(2010) Margaret E Harley et al.   EMBO JOURNAL

Mcl-1; the molecular regulation of protein function

(2010) Luke W. Thomas et al.   FEBS LETTERS

Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia

(2010) Zhifu Xiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Ubiquitin-Independent Degradation of Antiapoptotic MCL-1

(2010) D. P. Stewart et al.   MOLECULAR AND CELLULAR BIOLOGY

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications

(2010) Zhi Sheng et al.   NATURE MEDICINE

Evidence that Mitotic Exit Is a Better Cancer Therapeutic Target Than Spindle Assembly

(2009) Hsiao-Chun Huang et al.   CANCER CELL

MCL-1ES, a novel variant of MCL-1, associates with MCL-1L and induces mitochondrial cell death

(2009) Jae-Hong Kim et al.   FEBS LETTERS

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

(2009) Martin Schwickart et al.   NATURE

Glycolysis inhibition sensitizes tumor cells to death receptors-induced apoptosis by AMP kinase activation leading to Mcl-1 block in translation

(2009) L A Pradelli et al.   ONCOGENE

Down-regulation of Myeloid Cell Leukemia-1 through Inhibiting Erk/Pin 1 Pathway by Sorafenib Facilitates Chemosensitization in Breast Cancer

(2008) Q. Ding et al.   CANCER RESEARCH

Up-regulation of Mcl-1 Is Critical for Survival of Human Melanoma Cells upon Endoplasmic Reticulum Stress

(2008) C. C. Jiang et al.   CANCER RESEARCH

Mcl-1 Is a Key Regulator of Apoptosis during CNS Development and after DNA Damage

(2008) N. Arbour et al.   JOURNAL OF NEUROSCIENCE

Regulation of the proapoptotic factor Bax by Ku70-dependent deubiquitylation

(2008) Avigail D. Amsel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTORC1 promotes survival through translational control of Mcl-1

(2008) J. R. Mills et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA