Tobramycin Variants with Enhanced Ribosome-Targeting Activity

New trends in the use of aminoglycosides

(2014) Marina Y. Fosso et al.   MedChemComm

4′-O-substitutions determine selectivity of aminoglycoside antibiotics

(2014) Déborah Perez-Fernandez et al.   Nature Communications

Structure ofMycobacterium smegmatisEis in complex with paromomycin

(2014) Kyoung Hoon Kim et al.   Acta Crystallographica Section F-Structural Biology Communications

Chemical and Structural Insights into the Regioversatility of the Aminoglycoside Acetyltransferase Eis

(2013) Jacob L. Houghton et al.   CHEMBIOCHEM

Strategies to overcome the action of aminoglycoside-modifying enzymes for treating resistant bacterial infections

(2013) Kristin J Labby et al.   Future Medicinal Chemistry

Synthesis and Evaluation of Hetero- and Homodimers of Ribosome-Targeting Antibiotics: Antimicrobial Activity, in Vitro Inhibition of Translation, and Drug Resistance

(2013) Yifat Berkov-Zrihen et al.   JOURNAL OF MEDICINAL CHEMISTRY

6′′-Thioether Tobramycin Analogues: Towards Selective Targeting of Bacterial Membranes

(2012) Ido M. Herzog et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure-Activity Relationships among the Kanamycin Aminoglycosides: Role of Ring I Hydroxyl and Amino Groups

(2012) Sumantha Salian et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Selectively Guanidinylated Aminoglycosides as Antibiotics

(2012) Richard J. Fair et al.   ChemMedChem

Design, Synthesis, and Antibacterial Activities of Conformationally Constrained Kanamycin A Derivatives

(2012) Wenxuan Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Effects of Altering Aminoglycoside Structures on Bacterial Resistance Enzyme Activities

(2011) Keith D. Green et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Crystal Structures of Antibiotic-Bound Complexes of Aminoglycoside 2′′-Phosphotransferase IVa Highlight the Diversity in Substrate Binding Modes among Aminoglycoside Kinases

(2011) Kun Shi et al.   BIOCHEMISTRY

A Small Molecule Discrimination Map of the Antibiotic Resistance Kinome

(2011) Tushar Shakya et al.   CHEMISTRY & BIOLOGY

Neomycin−Neomycin Dimer: An All-Carbohydrate Scaffold with High Affinity for AT-Rich DNA Duplexes

(2011) Sunil Kumar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dissecting the cosubstrate structure requirements of the Staphylococcus aureus aminoglycoside resistance enzyme ANT(4′)

(2010) Vanessa R. Porter et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Aminoglycoside modifying enzymes

(2010) Maria S. Ramirez et al.   DRUG RESISTANCE UPDATES

Exploring the Substrate Promiscuity of Drug-Modifying Enzymes for the Chemoenzymatic Generation of N-Acylated Aminoglycosides

(2009) Keith D. Green et al.   CHEMBIOCHEM

Control of translation initiation involves a factor-induced rearrangement of helix 44 of 16S ribosomal RNA

(2009) Daoming Qin et al.   MOLECULAR MICROBIOLOGY

A nonradioactive high-throughput assay for screening and characterization of adenylation domains for nonribosomal peptide combinatorial biosynthesis

(2008) Thomas J. McQuade et al.   ANALYTICAL BIOCHEMISTRY

Mechanistic and Structural Analysis of AminoglycosideN-Acetyltransferase AAC(6′)-Ib and Its Bifunctional, Fluoroquinolone-Active AAC(6′)-Ib-cr Variant†‡

(2008) Matthew W. Vetting et al.   BIOCHEMISTRY