Development of Bifunctional Inhibitors of Polo-Like Kinase 1 with Low-Nanomolar Activities Against the Polo-Box Domain

Optimized Plk1 PBD Inhibitors Based on Poloxin Induce Mitotic Arrest and Apoptosis in Tumor Cells

(2015) Andrej Scharow et al.   ACS Chemical Biology

Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in hela cells

(2014) Wen-Jian Qian et al.   BIOPOLYMERS

Quantitative chemical proteomics reveals a Plk1 inhibitor-compromised cell death pathway in human cells

(2014) Monika Raab et al.   CELL RESEARCH

Identification of Green Tea Catechins as Potent Inhibitors of the Polo-Box Domain of Polo-Like kinase 1

(2014) Hong-Mei Shan et al.   ChemMedChem

A New Class of Peptidomimetics Targeting the Polo-Box Domain of Polo-Like Kinase 1

(2014) Mija Ahn et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and Synthesis of a Cell-Permeable, Drug-Like Small Molecule Inhibitor Targeting the Polo-Box Domain of Polo-Like Kinase 1

(2014) Ganipisetti Srinivasrao et al.   PLoS One

Thymoquinone Blocks pSer/pThr Recognition by Plk1 Polo-Box Domain As a Phosphate Mimic

(2012) Zhou Yin et al.   ACS Chemical Biology

Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides Using Oxime-Based Diversification

(2012) Fa Liu et al.   ACS Chemical Biology

High-Throughput Interrogation of Ligand Binding Mode Using a Fluorescence-Based Assay

(2012) Paweł Śledź et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Peptoid-Peptide Hybrid Ligands Targeting the Polo Box Domain of Polo-Like Kinase 1

(2012) Fa Liu et al.   CHEMBIOCHEM

Bioorthogonal Probes for Polo-like Kinase 1 Imaging and Quantification

(2011) Ghyslain Budin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

From Crystal Packing to Molecular Recognition: Prediction and Discovery of a Binding Site on the Surface of Polo-Like Kinase 1

(2011) Paweł Śledź et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phosphopeptides with improved cellular uptake properties as ligands for the polo-box domain of polo-like kinase 1

(2011) Susan Richter et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

From Plk1 to Plk5

(2011) Guillermo de Cárcer et al.   CELL CYCLE

Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel

(2011) Fa Liu et al.   Nature Chemical Biology

Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy

(2010) Klaus Strebhardt   NATURE REVIEWS DRUG DISCOVERY

Development of high-throughput assays based on fluorescence polarization for inhibitors of the polo-box domains of polo-like kinases 2 and 3

(2009) Wolfgang Reindl et al.   ANALYTICAL BIOCHEMISTRY

A Pan-Specific Inhibitor of the Polo-Box Domains of Polo-like Kinases Arrests Cancer Cells in Mitosis

(2009) Wolfgang Reindl et al.   CHEMBIOCHEM

Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1

(2009) Sang-Moon Yun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Polo-Like Kinase (PLK) Inhibitors in Preclinical and Early Clinical Development in Oncology

(2009) P. Schoffski   ONCOLOGIST

A high-throughput assay based on fluorescence polarization for inhibitors of the polo-box domain of polo-like kinase 1

(2008) Wolfgang Reindl et al.   ANALYTICAL BIOCHEMISTRY

Inhibition of Polo-like Kinase 1 by Blocking Polo-Box Domain-Dependent Protein-Protein Interactions

(2008) Wolfgang Reindl et al.   CHEMISTRY & BIOLOGY

Polo on the Rise—from Mitotic Entry to Cytokinesis with Plk1

(2008) Mark Petronczki et al.   DEVELOPMENTAL CELL

Deficiency in Chromosome Congression by the Inhibition of Plk1 Polo Box Domain-dependent Recognition

(2008) Nobumoto Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY