Design and Synthesis of a Cell-Permeable, Drug-Like Small Molecule Inhibitor Targeting the Polo-Box Domain of Polo-Like Kinase 1

Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1

(2013) Ravichandran N. Murugan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Exploring the Binding Nature of Pyrrolidine Pocket-Dependent Interactions in the Polo-Box Domain of Polo-Like Kinase 1

(2013) Ravichandran N. Murugan et al.   PLoS One

Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides Using Oxime-Based Diversification

(2012) Fa Liu et al.   ACS Chemical Biology

High-Throughput Interrogation of Ligand Binding Mode Using a Fluorescence-Based Assay

(2012) Paweł Śledź et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Effects on polo-like kinase 1 polo-box domain binding affinities of peptides incurred by structural variation at the phosphoamino acid position

(2012) Wenjian Qian et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Non-proteinogenic amino acids in the pThr-2 position of a pentamer peptide that confer high binding affinity for the polo box domain (PBD) of polo-like kinase 1 (Plk1)

(2012) Wen-Jian Qian et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Peptoid-Peptide Hybrid Ligands Targeting the Polo Box Domain of Polo-Like Kinase 1

(2012) Fa Liu et al.   CHEMBIOCHEM

Targeting Subcellular Localization through the Polo-Box Domain: Non-ATP Competitive Inhibitors Recapitulate a PLK1 Phenotype

(2012) C. McInnes et al.   MOLECULAR CANCER THERAPEUTICS

From Crystal Packing to Molecular Recognition: Prediction and Discovery of a Binding Site on the Surface of Polo-Like Kinase 1

(2011) Paweł Śledź et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Plk1-targeted small molecule inhibitors: molecular basis for their potency and specificity

(2011) Ravichandran N. Murugan et al.   MOLECULES AND CELLS

Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel

(2011) Fa Liu et al.   Nature Chemical Biology

Polo-box domain: a versatile mediator of polo-like kinase function

(2010) Jung-Eun Park et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A Direct, Regioselective Palladium-Catalyzed Synthesis of N-Substituted Benzimidazoles and Imidazopyridines

(2010) Jorge Alonso et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Probing Binding Modes of Small Molecule Inhibitors to the Polo-Box Domain of Human Polo-like Kinase 1

(2010) Chenzhong Liao et al.   ACS Medicinal Chemistry Letters

Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1

(2009) Sang-Moon Yun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inhibition of Polo-like Kinase 1 by Blocking Polo-Box Domain-Dependent Protein-Protein Interactions

(2008) Wolfgang Reindl et al.   CHEMISTRY & BIOLOGY

Deficiency in Chromosome Congression by the Inhibition of Plk1 Polo Box Domain-dependent Recognition

(2008) Nobumoto Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Small Molecular Scaffold for Selective Inhibition of Wip1 Phosphatase

(2007) Jeong Bang et al.   ChemMedChem