Ferroptosis and Acetaminophen Hepatotoxicity: Are We Going Down Another Rabbit Hole?

Novel Therapeutic Approaches Against Acetaminophen-induced Liver Injury and Acute Liver Failure

(2020) Hartmut Jaeschke et al.   TOXICOLOGICAL SCIENCES

Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure

(2020) Naoya Yamada et al.   Cell Death & Disease

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

(2020) Fulvio Ursini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Suppression of iron mobilization from lysosomes to mitochondria attenuates liver injury after acetaminophen overdose in vivo in mice: Protection by minocycline

(2020) Jiangting Hu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Aldehyde dehydrogenase-2 activation decreases acetaminophen hepatotoxicity by prevention of mitochondrial depolarization

(2020) Hereward J. Wimborne et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Emerging Mechanisms and Disease Relevance of Ferroptosis

(2020) Brent R. Stockwell et al.   TRENDS IN CELL BIOLOGY

(+)-Clausenamide protects against drug-induced liver injury by inhibiting hepatocyte ferroptosis

(2020) Min Wang et al.   Cell Death & Disease

CoQ10 protects against acetaminophen-induced liver injury by enhancing mitophagy

(2020) Peiwen Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice

(2020) Nga T. Nguyen et al.   TOXICOLOGY LETTERS

Acetaminophen Hepatotoxicity

(2019) Anup Ramachandran et al.   SEMINARS IN LIVER DISEASE

The molecular machinery of regulated cell death

(2019) Daolin Tang et al.   CELL RESEARCH

Emerging and established modes of cell death during acetaminophen-induced liver injury

(2019) Hartmut Jaeschke et al.   ARCHIVES OF TOXICOLOGY

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

The role of apoptosis in acetaminophen hepatotoxicity

(2018) Hartmut Jaeschke et al.   FOOD AND CHEMICAL TOXICOLOGY

Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity

(2018) Kuo Du et al.   ARCHIVES OF TOXICOLOGY

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

Iron and ferroptosis: A still ill-defined liaison

(2017) Sebastian Doll et al.   IUBMB LIFE

Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity

(2016) Kuo Du et al.   ARCHIVES OF TOXICOLOGY

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Translocation of iron from lysosomes to mitochondria during acetaminophen-induced hepatocellular injury: Protection by starch-desferal and minocycline

(2016) Jiangting Hu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential

(2016) Kuo Du et al.   Redox Biology

Acetaminophen: Dose-Dependent Drug Hepatotoxicity and Acute Liver Failure in Patients

(2015) Hartmut Jaeschke   DIGESTIVE DISEASES

The neuronal nitric oxide synthase inhibitor NANT blocks acetaminophen toxicity and protein nitration in freshly isolated hepatocytes

(2015) Sudip Banerjee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis

(2015) Lily Dara et al.   HEPATOLOGY

Ferroptosis is Involved in Acetaminophen Induced Cell Death

(2015) Tamás Lőrincz et al.   PATHOLOGY & ONCOLOGY RESEARCH

Lysosomal Instability and Cathepsin B Release during Acetaminophen Hepatotoxicity

(2015) Benjamin L. Woolbright et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice

(2013) Anup Ramachandran et al.   HEPATOLOGY

Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose–response, mechanisms, and clinical implications

(2013) Mitchell R. McGill et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

(2012) Hartmut Jaeschke et al.   DRUG METABOLISM REVIEWS

Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity

(2012) Mitchell R. McGill et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Activation of autophagy protects against acetaminophen-induced hepatotoxicity

(2011) Hong-Min Ni et al.   HEPATOLOGY

The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity

(2011) Anup Ramachandran et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury

(2010) Anup Ramachandran et al.   FREE RADICAL RESEARCH

Acetaminophen-Induced Hepatotoxicity in Mice Occurs with Inhibition of Activity and Nitration of Mitochondrial Manganese Superoxide Dismutase

(2010) R. Agarwal et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Lysosomal Iron Mobilization and Induction of the Mitochondrial Permeability Transition in Acetaminophen-Induced Toxicity to Mouse Hepatocytes

(2010) Kazuyoshi Kon et al.   TOXICOLOGICAL SCIENCES

The Oxygen Tension Modulates Acetaminophen-Induced Mitochondrial Oxidant Stress and Cell Injury in Cultured Hepatocytes

(2010) Hui-Min Yan et al.   TOXICOLOGICAL SCIENCES

Iron Potentiates Acetaminophen-Induced Oxidative Stress and Mitochondrial Dysfunction in Cultured Mouse Hepatocytes

(2010) Mi Sun Moon et al.   TOXICOLOGICAL SCIENCES

Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine

(2009) Chieko Saito et al.   HEPATOLOGY

Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury

(2008) Naoko Hanawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY