Immune compartments at the brain’s borders in health and neurovascular diseases

A mesothelium divides the subarachnoid space into functional compartments

(2023) Kjeld Møllgård et al.   SCIENCE

Single-cell Transcriptomic Profiling of the Hypothalamic Median Eminence during Aging

(2022) Zhen-Hua Chen et al.   Journal of Genetics and Genomics

Scavenger receptor CD36 governs recruitment of myeloid cells to the blood–CSF barrier after stroke in neonatal mice

(2022) Aditya Rayasam et al.   Journal of Neuroinflammation

Stroke induces disease-specific myeloid cells in the brain parenchyma and pia

(2022) Carolin Beuker et al.   Nature Communications

Aging Microbiota-Gut-Brain Axis in Stroke Risk and Outcome

(2022) Pedram Honarpisheh et al.   CIRCULATION RESEARCH

Specification of CNS macrophage subsets occurs postnatally in defined niches

(2022) Takahiro Masuda et al.   NATURE

Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels

(2022) Jose A. Mazzitelli et al.   NATURE NEUROSCIENCE

Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis

(2022) Fadi E. Pulous et al.   NATURE NEUROSCIENCE

Heterogeneity and developmental dynamics of LYVE-1 perivascular macrophages distribution in the mouse brain

(2022) Marie Karam et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Distinct roles of the meningeal layers in CNS autoimmunity

(2022) Arianna Merlini et al.   NATURE NEUROSCIENCE

Arachnoid granulations are lymphatic conduits that communicate with bone marrow and dura-arachnoid stroma

(2022) Trishna Shah et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid

(2022) Antoine Drieu et al.   NATURE

The meningeal transcriptional response to traumatic brain injury and aging

(2022) Ashley C Bolte et al.   eLife

Infiltration of meningeal macrophages into the Virchow–Robin space after ischemic stroke in rats: Correlation with activated PDGFR-β-positive adventitial fibroblasts

(2022) Tae-Ryong Riew et al.   Frontiers in Molecular Neuroscience

Morphology, localization, and postnatal development of dural macrophages

(2021) Takehito Sato et al.   CELL AND TISSUE RESEARCH

Role of perivascular and meningeal macrophages in outcome following experimental subarachnoid hemorrhage

(2021) Hoyee Wan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Functional characterization of the dural sinuses as a neuroimmune interface

(2021) Justin Rustenhoven et al.   CELL

T Cells Actively Infiltrate the White Matter of the Aging Monkey Brain in Relation to Increased Microglial Reactivity and Cognitive Decline

(2021) Katelyn V. Batterman et al.   Frontiers in Immunology

Stroke affects intestinal immune cell trafficking to the central nervous system

(2021) David Brea et al.   BRAIN BEHAVIOR AND IMMUNITY

A cellular and spatial map of the choroid plexus across brain ventricles and ages

(2021) Neil Dani et al.   CELL

Single-cell profiling of CNS border compartment leukocytes reveals that B cells and their progenitors reside in non-diseased meninges

(2021) David Schafflick et al.   NATURE NEUROSCIENCE

Bcl6 controls meningeal Th17–B cell interaction in murine neuroinflammation

(2021) Maike Hartlehnert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma

(2021) Andrea Cugurra et al.   SCIENCE

Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders

(2021) Simone Brioschi et al.   SCIENCE

Neutrophil Enzyme Myeloperoxidase Modulates Neuronal Response in a Model of Subarachnoid Hemorrhage by Venous Injury

(2021) Aminata P. Coulibaly et al.   STROKE

Macrophages on the margin: choroid plexus immune responses

(2021) Jin Cui et al.   TRENDS IN NEUROSCIENCES

Molecular trans-dural efflux to skull bone marrow in humans with cerebrospinal fluid disorders

(2021) Geir Ringstad et al.   BRAIN

Early developing B cells undergo negative selection by central nervous system-specific antigens in the meninges

(2021) Yan Wang et al.   IMMUNITY

Quantitative 3D imaging of the cranial microvascular environment at single-cell resolution

(2021) Alexandra N. Rindone et al.   Nature Communications

Activation of group 2 innate lymphoid cells alleviates aging-associated cognitive decline

(2020) Ivan Ting Hin Fung et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cerebrospinal fluid tracer efflux to parasagittal dura in humans

(2020) Geir Ringstad et al.   Nature Communications

Meningeal Immunity and Its Function in Maintenance of the Central Nervous System in Health and Disease

(2020) Kalil Alves de Lima et al.   Annual Review of Immunology

Defining molecular identity and fates of CNS-border associated macrophages after ischemic stroke in rodents and humans

(2020) Wenson D. Rajan et al.   NEUROBIOLOGY OF DISEASE

Endothelium-Macrophage Crosstalk Mediates Blood-Brain Barrier Dysfunction in Hypertension

(2020) Monica M. Santisteban et al.   HYPERTENSION

Direct Measurement of Cerebrospinal Fluid Production in Mice

(2020) Guojun Liu et al.   Cell Reports

Neuroinflammation-induced lymphangiogenesis near the cribriform plate contributes to drainage of CNS-derived antigens and immune cells

(2019) Martin Hsu et al.   Nature Communications

Tissue-Resident Group 2 Innate Lymphoid Cells Differentiate by Layered Ontogeny and In Situ Perinatal Priming

(2019) Christoph Schneider et al.   IMMUNITY

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment

(2019) Hannah Van Hove et al.   NATURE NEUROSCIENCE

Location of Neutrophils in Different Compartments of the Damaged Mouse Brain After Severe Ischemia/Reperfusion

(2019) Amaia Otxoa-de-Amezaga et al.   STROKE

The anatomy and immunology of vasculature in the central nervous system

(2019) Panagiotis Mastorakos et al.   Science Immunology

Brain perivascular macrophages contribute to the development of hypertension in stroke-prone spontaneously hypertensive rats via sympathetic activation

(2019) Takeshi Iyonaga et al.   HYPERTENSION RESEARCH

Brain-to-cervical lymph node signaling after stroke

(2019) Elga Esposito et al.   Nature Communications

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

(2018) Dunja Mrdjen et al.   IMMUNITY

Infiltrating macrophages contribute to age-related neuroinflammation in C57/BL6 mice

(2018) H. Wolfe et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Leukaemia hijacks a neural mechanism to invade the central nervous system

(2018) Hisayuki Yao et al.   NATURE

Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration

(2018) Fanny Herisson et al.   NATURE NEUROSCIENCE

CNS-border associated macrophages respond to acute ischemic stroke attracting granulocytes and promoting vascular leakage

(2018) Jordi Pedragosa et al.   Acta Neuropathologica Communications

Histological investigations on the dura mater vascular system of mice

(2018) Badreddine Mecheri et al.   ACTA HISTOCHEMICA

Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism

(2018) Cristina García-Cáceres et al.   NATURE NEUROSCIENCE

Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull–meninges connections

(2018) Ruiyao Cai et al.   NATURE NEUROSCIENCE

Microglia are continuously activated in the circumventricular organs of mouse brain

(2017) Shohei Takagi et al.   JOURNAL OF NEUROIMMUNOLOGY

Choroid plexus-cerebrospinal fluid route for monocyte-derived macrophages after stroke

(2017) Ruimin Ge et al.   Journal of Neuroinflammation

Where are we? The anatomy of the murine cortical meninges revisited for intravital imaging, immunology, and clearance of waste from the brain

(2017) Jonathan A. Coles et al.   PROGRESS IN NEUROBIOLOGY

Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice

(2017) Qiaoli Ma et al.   Nature Communications

Expansion of brain T cells in homeostatic conditions in lymphopenic Rag2−/− mice

(2016) Chang Song et al.   BRAIN BEHAVIOR AND IMMUNITY

Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension

(2016) Giuseppe Faraco et al.   JOURNAL OF CLINICAL INVESTIGATION

Characterization of meningeal type 2 innate lymphocytes and their response to CNS injury

(2016) Sachin P. Gadani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Origin, fate and dynamics of macrophages at central nervous system interfaces

(2016) Tobias Goldmann et al.   NATURE IMMUNOLOGY

Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells

(2016) Corinne Benakis et al.   NATURE MEDICINE

Heterogeneous vascular permeability and alternative diffusion barrier in sensory circumventricular organs of adult mouse brain

(2015) Shoko Morita et al.   CELL AND TISSUE RESEARCH

Mast Cells Promote Blood Brain Barrier Breakdown and Neutrophil Infiltration in a Mouse Model of Focal Cerebral Ischemia

(2015) Craig M McKittrick et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Head and Neck Veins of the Mouse. A Magnetic Resonance, Micro Computed Tomography and High Frequency Color Doppler Ultrasound Study

(2015) Marcello Mancini et al.   PLoS One

Neutrophil recruitment to the brain in mouse and human ischemic stroke

(2014) Isabel Perez-de-Puig et al.   ACTA NEUROPATHOLOGICA

Cranial Arachnoid Protrusions and Contiguous Diploic Veins in CSF Drainage

(2014) S. Tsutsumi et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Evidence that Meningeal Mast Cells Can Worsen Stroke Pathology in Mice

(2014) Ahmet Arac et al.   AMERICAN JOURNAL OF PATHOLOGY

The Superficial Glia Limitans of Mouse and Monkey Brain and Spinal Cord

(2014) Xiaofeng Liu et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Spontaneous white matter damage, cognitive decline and neuroinflammation in middle-aged hypertensive rats: an animal model of early-stage cerebral small vessel disease

(2014) Daniel Kaiser et al.   Acta Neuropathologica Communications

Sterile Inflammation after Permanent Distal MCA Occlusion in Hypertensive Rats

(2013) Karoline Möller et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Tanycyte-like cells form a blood-cerebrospinal fluid barrier in the circumventricular organs of the mouse brain

(2013) Fanny Langlet et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Mast cells on the mind: new insights and opportunities

(2013) Rae Silver et al.   TRENDS IN NEUROSCIENCES

The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury

(2012) Gaby Enzmann et al.   ACTA NEUROPATHOLOGICA

Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain

(2011) Niroshana Anandasabapathy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Brain Perivascular Macrophages and the Sympathetic Response to Inflammation in Rats After Myocardial Infarction

(2010) Yang Yu et al.   HYPERTENSION

Mast Cells as Early Responders in the Regulation of Acute Blood–Brain Barrier Changes after Cerebral Ischemia and Hemorrhage

(2010) Perttu Johannes Lindsberg et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Developmental and circulatory profile of the diploic veins

(2010) Haruki Toriumi et al.   MICROVASCULAR RESEARCH

Immune surveillance of the normal human CNS takes place in dependence of the locoregional blood-brain barrier configuration and is mainly performed by CD3+/CD8+ lymphocytes

(2010) Christian Loeffler et al.   NEUROPATHOLOGY

The diploic venous system: surgical anatomy and neurosurgical implications

(2009) Ulises García-González et al.   Neurosurgical Focus

Selective targeting of perivascular macrophages for clearance of  -amyloid in cerebral amyloid angiopathy

(2009) C. A. Hawkes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Venous Anatomy and Imaging of the First Centimeter

(2009) Neel Patel   SEMINARS IN ULTRASOUND CT AND MRI

Cerebrospinal fluid outflow: An evolving perspective

(2008) Kapil G. Kapoor et al.   BRAIN RESEARCH BULLETIN