Crystal structure and interaction studies of human DHTKD1 provide insight into a mitochondrial megacomplex in lysine catabolism

Human 2-Oxoglutarate Dehydrogenase and 2-Oxoadipate Dehydrogenase Both Generate Superoxide/H2O2 in a Side Reaction and Each Could Contribute to Oxidative Stress in Mitochondria

(2019) Frank Jordan et al.   NEUROCHEMICAL RESEARCH

Conformational transitions in the active site of mycobacterial 2-oxoglutarate dehydrogenase upon binding phosphonate analogues of 2-oxoglutarate: From a Michaelis-like complex to ThDP adducts

(2019) Tristan Wagner et al.   JOURNAL OF STRUCTURAL BIOLOGY

Evidence for functional and regulatory cross-talk between the tricarboxylic acid cycle 2-oxoglutarate dehydrogenase complex and 2-oxoadipate dehydrogenase on the l -lysine, l -hydroxylysine and l -tryptophan degradation pathways from studies in vitro

(2018) Natalia S. Nemeria et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Generation of superoxide and hydrogen peroxide by side reactions of mitochondrial 2-oxoacid dehydrogenase complexes in isolation and in cells

(2018) Victoria I. Bunik et al.   BIOLOGICAL CHEMISTRY

The mitochondrial 2-oxoadipate and 2-oxoglutarate dehydrogenase complexes share their E2 and E3 components for their function and both generate reactive oxygen species

(2018) Natalia S. Nemeria et al.   FREE RADICAL BIOLOGY AND MEDICINE

A multipronged approach unravels unprecedented protein–protein interactions in the human 2-oxoglutarate dehydrogenase multienzyme complex

(2018) Jieyu Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

A cell is more than the sum of its (dilute) parts: A brief history of quinary structure

(2017) Rachel D. Cohen et al.   PROTEIN SCIENCE

Recent developments in the CCP-EM software suite

(2017) Tom Burnley et al.   Acta Crystallographica Section D-Structural Biology

ATSAS 2.8: a comprehensive data analysis suite for small-angle scattering from macromolecular solutions

(2017) D. Franke et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Production of superoxide/hydrogen peroxide by the mitochondrial 2-oxoadipate dehydrogenase complex

(2016) Renata L.S. Goncalves et al.   FREE RADICAL BIOLOGY AND MEDICINE

Genetic basis of alpha-aminoadipic and alpha-ketoadipic aciduria

(2015) Jacob Hagen et al.   JOURNAL OF INHERITED METABOLIC DISEASE

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Why are the 2-oxoacid dehydrogenase complexes so large? Generation of an active trimeric complex

(2014) Nia L. Marrott et al.   BIOCHEMICAL JOURNAL

The 2-Oxoacid Dehydrogenase Complexes in Mitochondria Can Produce Superoxide/Hydrogen Peroxide at Much Higher Rates Than Complex I

(2014) Casey L. Quinlan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A dual conformation of the post-decarboxylation intermediate is associated with distinct enzyme states in mycobacterial KGD (α-ketoglutarate decarboxylase)

(2013) Tristan Wagner et al.   BIOCHEMICAL JOURNAL

DHTKD1 is essential for mitochondrial biogenesis and function maintenance

(2013) Wangyang Xu et al.   FEBS LETTERS

A Nonsense Mutation in DHTKD1 Causes Charcot-Marie-Tooth Disease Type 2 in a Large Chinese Pedigree

(2012) Wang-yang Xu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

DHTKD1 Mutations Cause 2-Aminoadipic and 2-Oxoadipic Aciduria

(2012) Katharina Danhauser et al.   AMERICAN JOURNAL OF HUMAN GENETICS

On the role of the mitochondrial 2-oxoglutarate dehydrogenase complex in amino acid metabolism

(2012) Wagner L. Araújo et al.   AMINO ACIDS

Prevention of overfitting in cryo-EM structure determination

(2012) Sjors H W Scheres et al.   NATURE METHODS

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Revealing the Allosterome: Systematic Identification of Metabolite–Protein Interactions

(2011) Thomas Orsak et al.   BIOCHEMISTRY

Functional Plasticity and Allosteric Regulation of α-Ketoglutarate Decarboxylase in Central Mycobacterial Metabolism

(2011) Tristan Wagner et al.   CHEMISTRY & BIOLOGY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Interaction of E1 and E3 components with the core proteins of the human pyruvate dehydrogenase complex

(2009) Mulchand S. Patel et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Novel isoenzyme of 2-oxoglutarate dehydrogenase is identified in brain, but not in heart

(2008) Victoria Bunik et al.   FEBS Journal

CHAINSAW: a program for mutating pdb files used as templates in molecular replacement

(2008) Norman Stein   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Structures of the Human Pyruvate Dehydrogenase Complex Cores: A Highly Conserved Catalytic Center with Flexible N-Terminal Domains

(2008) Xuekui Yu et al.   STRUCTURE

Structure-function relationships in the 2-oxo acid dehydrogenase family: Substrate-specific signatures and functional predictions for the 2-oxoglutarate dehydrogenase-like proteins

(2007) Victoria I. Bunik et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS