Article
Biochemistry & Molecular Biology
Mohammed Al-Chawishly, Oliver Loveland, Alison M. Gurney
Summary: Kv7.4 channels contribute to endothelium-dependent dilation and the effects of drugs that act by stimulating cGMP, but not cAMP, signalling.
Article
Pharmacology & Pharmacy
Silvijus Abramavicius, Asbjorn G. Petersen, Nirthika S. Renaltan, Judit Prat-Duran, Roberta Torregrossa, Edgaras Stankevicius, Matthew Whiteman, Ulf Simonsen
Summary: The study suggests that L-cysteine inhibits relaxations induced by Na2S and GYY4137 by forming sulfides. The rate of release of H2S species from GYY4137 affects the sensitivity of relaxations towards high K+ concentration and potassium channel blockers, indicating a potential beneficial effect of GYY4137 in treating cardiovascular diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xinhe Yang, Shuai Chen, Shuo Zhang, Sai Shi, Rui Zong, Yiting Gao, Bingcai Guan, Nikita Gamper, Haixia Gao
Summary: Zinc serves as a cofactor for numerous enzymes, transcription factors, receptors, and other proteins. It acts as an important signaling molecule and can activate Kv7 channels, protecting neurons from overactivity.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Neurosciences
Pamela J. Urrutia, Christian Gonzalez-Billault
Summary: Neuronal polarization is a complex process regulated by various intrinsic and extrinsic mechanisms. The review summarizes the role of second messengers, such as Ca21, IP3, cAMP, cGMP, and hydrogen peroxide, in controlling different aspects of neuronal polarization. It also highlights the remaining challenges in fully understanding the cellular processes involved in axodendritic polarization.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Physiology
Yibin Wang, Fatima Yildiz, Andrey Struve, Mario Kassmann, Lajos Marko, May-Britt Kohler, Friedrich C. Luft, Maik Gollasch, Dmitry Tsvetkov
Summary: Aging is an independent risk factor for hypertension, cardiovascular morbidity, and mortality, however, the detailed mechanisms are unclear. This study demonstrated that aging impairs the control of vascular tone via K(v)7 channels in perivascular adipose tissue, and identified QO58 as a novel pharmacological vasodilator for aging-related vascular dysfunction. Targeting inflammation and metabolism in perivascular adipose tissue may represent new approaches for restoring vascular function during aging.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Bhaskar Jyoti Dutta, Shamsher Singh, Sanket Seksaria, Ghanshyam Das Gupta, Surendra H. Bodakhe, Amrita Singh
Summary: Despite significant investments, no disease-modifying medications for Alzheimer's disease have been found. More in-depth understanding of the pathophysiology and innovative therapeutic strategies are needed. Targeting signaling cascades and calcium dysregulation show promise in clinical trials.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Danfeng Zhang, Bernhard M. Krause, Hans-Gunther Schmalz, Paulus Wohlfart, Benito A. Yard, Rudolf Schubert
Summary: The mechanism by which carbon monoxide (CO) mediates vasodilation is not completely understood, with inconsistency in the types of K+-channels activated by CO releasing molecules (CORMs) in published studies. This study found that Kv7 channels are the main channel through which ET-CORM rac-4 mediates vasodilation, suggesting potential use of ET-CORMs in cardiovascular diseases warrants further in vivo studies.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Arun Samidurai, Lei Xi, Anindita Das, Audra N. Iness, Navin G. Vigneshwar, Pin-Lan Li, Dinender K. Singla, Sakthivel Muniyan, Surinder K. Batra, Rakesh C. Kukreja
Summary: Cyclic nucleotide phosphodiesterases (PDEs) are a superfamily of enzymes that regulate the spatial and temporal relationship of second messenger signaling in the cellular system. The PDE1 sub-family consists of three subtypes with different affinities for cAMP and cGMP, and their catalytic activity is stimulated by binding to Ca2+/calmodulin, playing a critical role in various diseases.
PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Endocrinology & Metabolism
Stepan Gambaryan, Sanika Mohagaonkar, Viacheslav O. Nikolaev
Summary: The renin-angiotensin-aldosterone system (RAAS) plays a crucial role in blood volume and blood pressure regulation, and its dysfunction is associated with cardiovascular and renal diseases. Cyclic nucleotides and phosphodiesterases are the main regulators of this system, controlling the expression and activity of renin and aldosterone. This review summarizes the known mechanisms by which cyclic nucleotides and phosphodiesterases regulate the expression of renin gene, secretion of renin granules, and production of aldosterone, as well as highlighting some unanswered questions for future research.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Bryan VanSchouwen, Stephen Boulton, Giuseppe Melacini
Summary: This study using NMR reveals that the contributions of the two substituents of cGMP to the binding affinity of PKG are surprisingly nonadditive, primarily due to mutual protein-ligand conformational selection. The 6-oxo substituent controls the conformational equilibrium of the bound protein, while the 2-NH2 substituent primarily controls the conformational equilibrium of the unbound ligand. Understanding the conformational dynamics of both the protein and ligand is essential to explain the cGMP-versus-cAMP selectivity of PKG.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Review
Plant Sciences
Brygida Swiezawska-Boniecka, Maria Duszyn, Mateusz Kwiatkowski, Adriana Szmidt-Jaworska, Krzysztof Jaworski
Summary: Plant cellular activities are regulated by mechanisms controlling the level of signal molecules and calcium ions. Studies have shown that while cNMPs and Ca2(+) can act independently, they can also interact and function together. Maintaining a balance between Ca2(+) and cNMP is crucial for cellular homeostasis.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Multidisciplinary Sciences
Tamer M. Gamal El-Din, Timothy Lantin, Christopher W. Tschumi, Barbara Juarez, Meagan Quinlan, Julia H. Hayano, Jin Li, Larry S. Zweifel, William A. Catterall
Summary: Autism spectrum disorder affects over 1% of children in the United States, resulting in social interaction deficits, repetitive behaviors, and communication disorders. Genetic analysis through genome sequencing has identified over 500 genes with mutations in ASD, suggesting that altered control of action potential generation by gating pore current through mutant K(v)7 channels may be a potential pathogenic mechanism in autism.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Kogiku Shiba, Kazuo Inaba
Summary: Spermatozoa can sense and respond to environmental signals to ensure successful fertilization. In the ascidian Ciona intestinalis, CNG channels play a vital role in regulating sperm motility and intracellular calcium regulation during chemotaxis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Mariia Khamina, Karla Martinez Pomier, Madoka Akimoto, Bryan VanSchouwen, Giuseppe Melacini
Summary: The protein kinases PKA and PKG can be activated by not only cyclic nucleotides, but also a wide range of non-canonical allosteric effectors. The molecular mechanisms involve shifts in dynamical regulatory equilibria and modulation of inter-protomer interactions. Mutations can lead to constitutive kinase activation, resulting in physiological or pathological outcomes.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Moawiah M. Naffaa, Ola A. Al-Ewaidat
Summary: KCNQ-encoded potassium channels play diverse roles in human tissues, affecting various physiological processes and pathophysiological conditions. New, more selective and potent molecules targeting Kv7 channels are desired for effective therapies. Understanding the structure and function of human KCNQ-encoded channels helps in achieving these therapeutic goals.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Vincenzo Barrese, Jennifer B. Stott, Iain A. Greenwood
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 58
(2018)
Article
Hematology
Jennifer B. Stott, Vincenzo Barrese, Malavika Suresh, Shirou Masoodi, Iain A. Greenwood
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2018)
Article
Hematology
Leon J. DeLalio, Alexander S. Keller, Jiwang Chen, Andrew K. J. Boyce, Mykhaylo V. Artamonov, Henry R. Askew-Page, T. C. Stevenson Keller, Scott R. Johnstone, Rachel B. Weaver, Miranda E. Good, Sara A. Murphy, Angela K. Best, Ellen L. Mintz, Silvia Penuela, Iain A. Greenwood, Roberto F. Machado, Avril V. Somlyo, Leigh Anne Swayne, Richard D. Minshall, Brant E. Isakson
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2018)
Article
Peripheral Vascular Disease
Vincenzo Barrese, Jennifer B. Stott, Hericka B. Figueiredo, Aisah A. Aubdool, Adrian J. Hobbs, Thomas A. Jepps, Alister J. McNeish, Iain A. Greenwood
Article
Pharmacology & Pharmacy
Henry R. Askew Page, Thomas Dalsgaard, Samuel N. Baldwin, Thomas A. Jepps, Oleksandr Povstyan, Soren P. Olesen, Iain A. Greenwood
BRITISH JOURNAL OF PHARMACOLOGY
(2019)
Article
Cell Biology
Ramon J. Ayon, Matthew B. Hawn, Joydeep Aoun, Michael Wiwchar, Abigail S. Forrest, Fiona Cunningham, Cherie A. Singer, Maria L. Valencik, Iain A. Greenwood, Normand Leblanc
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2019)
Article
Physiology
Iain A. Greenwood, Jennifer B. Stott
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Hematology
Vincenzo Barrese, Jennifer B. Stott, Samuel N. Baldwin, Gema Mondejar-Parreno, Iain A. Greenwood
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2020)
Article
Pharmacology & Pharmacy
Kazi S. Jahan, Jian Shi, Harry Z. E. Greenberg, Sam Khavandi, Miguel Martin-Aragon Baudel, Vincenzo Barrese, Iain A. Greenwood, Anthony P. Albert
VASCULAR PHARMACOLOGY
(2020)
Review
Physiology
Jennifer van der Horst, Iain A. Greenwood, Thomas A. Jepps
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Peripheral Vascular Disease
Gema Mondejar-Parreno, Bianca Barreira, Maria Callejo, Daniel Morales-Cano, Vincenzo Barrese, Sergio Esquivel-Ruiz, Miguel A. Olivencia, Miguel Macias, Laura Moreno, Iain A. Greenwood, Francisco Perez-Vizcaino, Angel Cogolludo
Article
Physiology
Samuel N. Baldwin, Shaun L. Sandow, Gema Mondejar-Parreno, Jennifer B. Stott, Iain A. Greenwood
FRONTIERS IN PHYSIOLOGY
(2020)
