PARP1 associates with R-loops to promote their resolution and genome stability

Functions of ADP-ribose transferases in the maintenance of telomere integrity

(2022) Daniela Muoio et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes

(2022) Anna Maria Sole Giordano et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibitors of PARP: Number crunching and structure gazing

(2022) Johannes Rudolph et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of R-loop recognition by the S9.6 monoclonal antibody

(2022) Charles Bou-Nader et al.   Nature Communications

DDX18 prevents R-loop-induced DNA damage and genome instability via PARP-1

(2022) Wen-Ling Lin et al.   Cell Reports

Sensing R-Loop-Associated DNA Damage to Safeguard Genome Stability

(2021) Carlo Rinaldi et al.   Frontiers in Cell and Developmental Biology

Poly-ADP-ribosylation drives loss of protein homeostasis in ATM and Mre11 deficiency

(2021) Ji-Hoon Lee et al.   MOLECULAR CELL

PARP1-mediated PARylation of TonEBP prevents R-loop–associated DNA damage

(2021) Byeong Jin Ye et al.   DNA REPAIR

Recognition of RNA by the S9.6 antibody creates pervasive artifacts when imaging RNA:DNA hybrids

(2021) John A. Smolka et al.   JOURNAL OF CELL BIOLOGY

Untangling the crosstalk between BRCA1 and R-loops during DNA repair

(2021) Marta San Martin Alonso et al.   NUCLEIC ACIDS RESEARCH

ADP-ribosylation of DNA and RNA

(2021) Joséphine Groslambert et al.   DNA REPAIR

ADP‐ribosyltransferases, an update on function and nomenclature

(2021) Bernhard Lüscher et al.   FEBS Journal

UPF1 promotes the formation of R loops to stimulate DNA double-strand break repair

(2021) Greg H. P. Ngo et al.   Nature Communications

Harmful R-loops are prevented via different cell cycle-specific mechanisms

(2021) Marta San Martin-Alonso et al.   Nature Communications

A Tale of Loops and Tails: The Role of Intrinsically Disordered Protein Regions in R-Loop Recognition and Phase Separation

(2021) Leonardo G. Dettori et al.   Frontiers in Molecular Biosciences

Defining R-loop classes and their contributions to genome instability

(2021) Daisy Castillo-Guzman et al.   DNA REPAIR

R-loops trigger the release of cytoplasmic ssDNAs leading to chronic inflammation upon DNA damage

(2021) Ourania Chatzidoukaki et al.   Science Advances

Insight into DNA substrate specificity of PARP1-catalysed DNA poly(ADP-ribosyl)ation

(2020) Elie Matta et al.   Scientific Reports

UAP56/DDX39B is a major cotranscriptional RNA–DNA helicase that unwinds harmful R loops genome-wide

(2020) Carmen Pérez-Calero et al.   GENES & DEVELOPMENT

Cohesin SA1 and SA2 are RNA binding proteins that localize to RNA containing regions on DNA

(2020) Hai Pan et al.   NUCLEIC ACIDS RESEARCH

Structural basis for allosteric PARP-1 retention on DNA breaks

(2020) Levani Zandarashvili et al.   SCIENCE

Genome-wide R-loop analysis defines unique roles for DDX5, XRN2, and PRMT5 in DNA/RNA hybrid resolution

(2020) Oscar D Villarreal et al.   Life Science Alliance

RAD51-dependent recruitment of TERRA lncRNA to telomeres through R-loops

(2020) Marianna Feretzaki et al.   NATURE

BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage

(2020) Fred C. Lam et al.   Nature Communications

XRN2 interactome reveals its synthetic lethal relationship with PARP1 inhibition

(2020) Praveen L. Patidar et al.   Scientific Reports

BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation

(2020) Drake S. Edwards et al.   Cell Reports

SFPQ and NONO suppress RNA:DNA-hybrid-related telomere instability

(2019) Eleonora Petti et al.   Nature Communications

The extruded non-template strand determines the architecture of R-loops

(2019) Yeraldinne Carrasco-Salas et al.   NUCLEIC ACIDS RESEARCH

Arginine methylation of the DDX 5 helicase RGG / RG motif by PRMT 5 regulates resolution of RNA:DNA hybrids

(2019) Sofiane Y Mersaoui et al.   EMBO JOURNAL

Activation of PARP-1 by snoRNAs Controls Ribosome Biogenesis and Cell Growth via the RNA Helicase DDX21

(2019) Dae-Seok Kim et al.   MOLECULAR CELL

Perspectives on PARPs in S Phase

(2019) Hana Hanzlikova et al.   TRENDS IN GENETICS

Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks

(2019) Agnese Cristini et al.   Cell Reports

R Loops: From Physiological to Pathological Roles

(2019) Tatiana García-Muse et al.   CELL

Nonspecific Binding of RNA to PARP1 and PARP2 Does Not Lead to Catalytic Activation

(2019) Meagan Y. Nakamoto et al.   BIOCHEMISTRY

R-loops: targets for nuclease cleavage and repeat instability

(2018) Catherine H. Freudenreich   CURRENT GENETICS

DNA:RNA hybrids at telomeres - when it is better to be out of the (R) loop

(2018) Shir Toubiana et al.   FEBS Journal

The Affinity of the S9.6 Antibody for Double-Stranded RNAs Impacts the Accurate Mapping of R-Loops in Fission Yeast

(2018) Stella R. Hartono et al.   JOURNAL OF MOLECULAR BIOLOGY

The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations

(2018) Liang Chen et al.   MOLECULAR CELL

RNA/DNA Hybrid Interactome Identifies DXH9 as a Molecular Player in Transcriptional Termination and R-Loop-Associated DNA Damage

(2018) Agnese Cristini et al.   Cell Reports

R-loop generation during transcription: Formation, processing and cellular outcomes

(2018) Boris P. Belotserkovskii et al.   DNA REPAIR

Genome-wide Map of R-Loop-Induced Damage Reveals How a Subset of R-Loops Contributes to Genomic Instability

(2018) Lorenzo Costantino et al.   MOLECULAR CELL

A two-nuclease pathway involving RNase H1 is required for primer removal at human mitochondrial OriL

(2018) Ali Al-Behadili et al.   NUCLEIC ACIDS RESEARCH

Systems-wide Analysis of Serine ADP-Ribosylation Reveals Widespread Occurrence and Site-Specific Overlap with Phosphorylation

(2018) Sara C. Larsen et al.   Cell Reports

DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells

(2018) Alessio De Magis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RECQ-like helicases Sgs1 and BLM regulate R-loop–associated genome instability

(2017) Emily Yun-Chia Chang et al.   JOURNAL OF CELL BIOLOGY

Lead Discovery of Dual G-Quadruplex Stabilizers and Poly(ADP-ribose) Polymerases (PARPs) Inhibitors: A New Avenue in Anticancer Treatment

(2017) Erica Salvati et al.   JOURNAL OF MEDICINAL CHEMISTRY

Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1

(2017) Hai Dang Nguyen et al.   MOLECULAR CELL

PARP1 changes from three-dimensional DNA damage searching to one-dimensional diffusion after auto-PARylation or in the presence of APE1

(2017) Lili Liu et al.   NUCLEIC ACIDS RESEARCH

A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation

(2017) Lilian Kabeche et al.   SCIENCE

Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybrids

(2017) Shira Sagie et al.   Nature Communications

Preventing replication fork collapse to maintain genome integrity

(2015) David Cortez   DNA REPAIR

Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1

(2015) Sebastian Eustermann et al.   MOLECULAR CELL

PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain

(2015) Jennine M. Dawicki-McKenna et al.   MOLECULAR CELL

R loops: new modulators of genome dynamics and function

(2015) José M. Santos-Pereira et al.   NATURE REVIEWS GENETICS

The spliceosome-associated protein Nrl1 suppresses homologous recombination-dependent R-loop formation in fission yeast

(2015) Lucia Aronica et al.   NUCLEIC ACIDS RESEARCH

Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)

(2015) Matthias Altmeyer et al.   Nature Communications

The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability

(2014) Stephan Hamperl et al.   DNA REPAIR

Transcription-Coupled Nucleotide Excision Repair Factors Promote R-Loop-Induced Genome Instability

(2014) Julie Sollier et al.   MOLECULAR CELL

PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress

(2014) Giuditta Illuzzi et al.   NUCLEIC ACIDS RESEARCH

PARP-2 and PARP-3 are selectively activated by 5′ phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1

(2014) Marie-France Langelier et al.   NUCLEIC ACIDS RESEARCH

Out of Balance: R-loops in Human Disease

(2014) Matthias Groh et al.   PLoS Genetics

The THO complex component Thp2 counteracts telomeric R-loops and telomere shortening

(2013) Verena Pfeiffer et al.   EMBO JOURNAL

GC skew at the 5' and 3' ends of human genes links R-loop formation to epigenetic regulation and transcription termination

(2013) P. A. Ginno et al.   GENOME RESEARCH

Stereospecific PARP Trapping by BMN 673 and Comparison with Olaparib and Rucaparib

(2013) J. Murai et al.   MOLECULAR CANCER THERAPEUTICS

The Rs of Biology: R-Loops and the Regulation of Regulators

(2013) Lamia Wahba et al.   MOLECULAR CELL

TRF1 and TRF2 use different mechanisms to find telomeric DNA but share a novel mechanism to search for protein partners at telomeres

(2013) Jiangguo Lin et al.   NUCLEIC ACIDS RESEARCH

DNA-RNA hybrid formation mediates RNAi-directed heterochromatin formation

(2012) Mina Nakama et al.   GENES TO CELLS

R-Loop Formation Is a Distinctive Characteristic of Unmethylated Human CpG Island Promoters

(2012) Paul A. Ginno et al.   MOLECULAR CELL

R Loops: From Transcription Byproducts to Threats to Genome Stability

(2012) Andrés Aguilera et al.   MOLECULAR CELL

Quantitative proteomics profiling of the poly(ADP-ribose)-related response to genotoxic stress

(2012) Jean-Philippe Gagné et al.   NUCLEIC ACIDS RESEARCH

The Guanine-Quadruplex Structure in the Human c-myc Gene's Promoter Is Converted into B-DNA Form by the Human Poly(ADP-Ribose)Polymerase-1

(2012) Anna Fekete et al.   PLoS One

Structural Basis for DNA Damage-Dependent Poly(ADP-ribosyl)ation by Human PARP-1

(2012) M.-F. Langelier et al.   SCIENCE

Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA

(2011) Marie-France Langelier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination

(2011) Konstantina Skourti-Stathaki et al.   MOLECULAR CELL

PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy

(2010) E Salvati et al.   ONCOGENE

Investigation of PARP-1, PARP-2, and PARG interactomes by affinity-purification mass spectrometry

(2010) Maxim Isabelle et al.   Proteome Science

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination

(2009) Helen E Bryant et al.   EMBO JOURNAL

First Evidence of a Functional Interaction between DNA Quadruplexes and Poly(ADP-ribose) Polymerase-1

(2008) V. A. Soldatenkov et al.   ACS Chemical Biology

Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes

(2008) Jean-Philippe Gagné et al.   NUCLEIC ACIDS RESEARCH