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Title
Sensing R-Loop-Associated DNA Damage to Safeguard Genome Stability
Authors
Keywords
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Journal
Frontiers in Cell and Developmental Biology
Volume 8, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-01-13
DOI
10.3389/fcell.2020.618157
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Note: Only part of the references are listed.- Emerging roles for R-loop structures in the management of topological stress
- (2020) Frederic Chedin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ultra-Deep Coverage Single-Molecule R-loop Footprinting Reveals Principles of R-loop Formation
- (2020) Maika Malig et al. JOURNAL OF MOLECULAR BIOLOGY
- The dark side of RNA:DNA hybrids
- (2020) Alessandra Brambati et al. MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
- Regulatory R-loops as facilitators of gene expression and genome stability
- (2020) Christof Niehrs et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Homologous recombination and Mus81 promote replication completion in response to replication fork blockage
- (2020) Benjamin Pardo et al. EMBO REPORTS
- DNA:RNA hybrids form at DNA double-strand breaks in transcriptionally active loci
- (2020) Aldo S. Bader et al. Cell Death & Disease
- Senataxin Ortholog Sen1 Limits DNA:RNA Hybrid Accumulation at DNA Double-Strand Breaks to Control End Resection and Repair Fidelity
- (2020) Chetan C. Rawal et al. Cell Reports
- qDRIP: a method to quantitatively assess RNA–DNA hybrid formation genome-wide
- (2020) Magdalena P Crossley et al. NUCLEIC ACIDS RESEARCH
- Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites
- (2020) Alexy Promonet et al. Nature Communications
- Origin matters: spontaneous DNA–RNA hybrids do not form in trans as a source of genome instability
- (2020) Belén Gómez-González et al. CURRENT GENETICS
- ATM pathway activation limits R-loop-associated genomic instability in Werner syndrome cells
- (2019) Veronica Marabitti et al. NUCLEIC ACIDS RESEARCH
- Interplay between DNA sequence and negative superhelicity drives R-loop structures
- (2019) Robert Stolz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- R-Loops as Cellular Regulators and Genomic Threats
- (2019) Madzia P. Crossley et al. MOLECULAR CELL
- BRCA1-associated R-loop affects transcription and differentiation in breast luminal epithelial cells
- (2019) Huai-Chin Chiang et al. NUCLEIC ACIDS RESEARCH
- The DNA damage response acts as a safeguard against harmful DNA–RNA hybrids of different origins
- (2019) Sonia Barroso et al. EMBO REPORTS
- Yeast Sirtuin Family Members Maintain Transcription Homeostasis to Ensure Genome Stability
- (2019) Jessica L. Feldman et al. Cell Reports
- Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks
- (2019) Agnese Cristini et al. Cell Reports
- R Loops: From Physiological to Pathological Roles
- (2019) Tatiana García-Muse et al. CELL
- ATR Protects the Genome against R Loops through a MUS81-Triggered Feedback Loop
- (2019) Dominick A. Matos et al. MOLECULAR CELL
- The balancing act of R-loop biology: The good, the bad, and the ugly
- (2019) Youssef A. Hegazy et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- R-loops: targets for nuclease cleavage and repeat instability
- (2018) Catherine H. Freudenreich CURRENT GENETICS
- Yra1-bound RNA–DNA hybrids cause orientation-independent transcription–replication collisions and telomere instability
- (2018) María García-Rubio et al. GENES & DEVELOPMENT
- Senataxin Mutation Reveals How R-Loops Promote Transcription by Blocking DNA Methylation at Gene Promoters
- (2018) Christopher Grunseich et al. MOLECULAR CELL
- The Cellular Response to Transcription-Blocking DNA Damage
- (2018) Lea H. Gregersen et al. TRENDS IN BIOCHEMICAL SCIENCES
- Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair
- (2018) Wei-Ting Lu et al. Nature Communications
- Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations
- (2018) Sarah Cohen et al. Nature Communications
- BRCA2 Regulates Transcription Elongation by RNA Polymerase II to Prevent R-Loop Accumulation
- (2018) Mahmud K.K. Shivji et al. Cell Reports
- Genome-wide Map of R-Loop-Induced Damage Reveals How a Subset of R-Loops Contributes to Genomic Instability
- (2018) Lorenzo Costantino et al. MOLECULAR CELL
- Transcription shapes DNA replication initiation and termination in human cells
- (2018) Yu-Hung Chen et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment
- (2018) Giuseppina D’Alessandro et al. Nature Communications
- RECQ-like helicases Sgs1 and BLM regulate R-loop–associated genome instability
- (2017) Emily Yun-Chia Chang et al. JOURNAL OF CELL BIOLOGY
- Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1
- (2017) Hai Dang Nguyen et al. MOLECULAR CELL
- R-ChIP Using Inactive RNase H Reveals Dynamic Coupling of R-loops with Transcriptional Pausing at Gene Promoters
- (2017) Liang Chen et al. MOLECULAR CELL
- Histone Mutants Separate R Loop Formation from Genome Instability Induction
- (2017) Desiré García-Pichardo et al. MOLECULAR CELL
- Introns Protect Eukaryotic Genomes from Transcription-Associated Genetic Instability
- (2017) Amandine Bonnet et al. MOLECULAR CELL
- ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response
- (2017) Andrew N. Blackford et al. MOLECULAR CELL
- Dormant origins and fork protection mechanisms rescue sister forks arrested by transcription
- (2017) Alessandra Brambati et al. NUCLEIC ACIDS RESEARCH
- A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation
- (2017) Lilian Kabeche et al. SCIENCE
- Spatial and Temporal Control of Evolution through Replication–Transcription Conflicts
- (2017) Houra Merrikh TRENDS IN MICROBIOLOGY
- Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis
- (2017) Xiaowen Zhang et al. Nature Communications
- The Role of Replication-Associated Repair Factors on R-Loops
- (2017) et al. Genes
- Replication Fork Protection Factors Controlling R-Loop Bypass and Suppression
- (2017) Emily Chang et al. Genes
- R-loop: an emerging regulator of chromatin dynamics: Table 1.
- (2016) Qais Al-Hadid et al. ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- Transient RNA-DNA Hybrids Are Required for Efficient Double-Strand Break Repair
- (2016) Corina Ohle et al. CELL
- Conflict Resolution in the Genome: How Transcription and Replication Make It Work
- (2016) Stephan Hamperl et al. CELL
- Mec1, INO80, and the PAF1 complex cooperate to limit transcription replication conflicts through RNAPII removal during replication stress
- (2016) Jérôme Poli et al. GENES & DEVELOPMENT
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- (2016) Lamia Wahba et al. GENES & DEVELOPMENT
- DICER, DROSHA and DNA damage response RNAs are necessary for the secondary recruitment of DNA damage response factors
- (2016) Sofia Francia et al. JOURNAL OF CELL SCIENCE
- Prevalent, Dynamic, and Conserved R-Loop Structures Associate with Specific Epigenomic Signatures in Mammals
- (2016) Lionel A. Sanz et al. MOLECULAR CELL
- Transcription–replication conflicts: how they occur and how they are resolved
- (2016) Tatiana García-Muse et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Bidirectional coupling of splicing and ATM signaling in response to transcription-blocking DNA damage
- (2016) Maria Tresini et al. RNA Biology
- Increased global transcription activity as a mechanism of replication stress in cancer
- (2016) Panagiotis Kotsantis et al. Nature Communications
- Replication landscape of the human genome
- (2016) Nataliya Petryk et al. Nature Communications
- The Yin and Yang of R-loop biology
- (2015) Lorenzo Costantino et al. CURRENT OPINION IN CELL BIOLOGY
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- (2015) Olivier J. Becherel et al. HUMAN MOLECULAR GENETICS
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- BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair
- (2015) Elodie Hatchi et al. MOLECULAR CELL
- The core spliceosome as target and effector of non-canonical ATM signalling
- (2015) Maria Tresini et al. NATURE
- ATM Dependent Silencing Links Nucleolar Chromatin Reorganization to DNA Damage Recognition
- (2015) Shane M. Harding et al. Cell Reports
- The Fanconi Anemia Pathway Protects Genome Integrity from R-loops
- (2015) María L. García-Rubio et al. PLoS Genetics
- Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi–Goutières syndrome
- (2015) Yoong Wearn Lim et al. eLife
- Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination
- (2014) Min Gao et al. CELL RESEARCH
- The yeast and human FACT chromatin-reorganizing complexes solve R-loop-mediated transcription-replication conflicts
- (2014) E. Herrera-Moyano et al. GENES & DEVELOPMENT
- Defective removal of ribonucleotides from DNA promotes systemic autoimmunity
- (2014) Claudia Günther et al. JOURNAL OF CLINICAL INVESTIGATION
- Transcription-Coupled Nucleotide Excision Repair Factors Promote R-Loop-Induced Genome Instability
- (2014) Julie Sollier et al. MOLECULAR CELL
- Arginine Methylation Facilitates the Recruitment of TOP3B to Chromatin to Prevent R Loop Accumulation
- (2014) Yanzhong Yang et al. MOLECULAR CELL
- BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2
- (2014) Vaibhav Bhatia et al. NATURE
- R-loops Associated with Triplet Repeat Expansions Promote Gene Silencing in Friedreich Ataxia and Fragile X Syndrome
- (2014) Matthias Groh et al. PLoS Genetics
- Identification of Early Replicating Fragile Sites that Contribute to Genome Instability
- (2013) Jacqueline H. Barlow et al. CELL
- GC skew at the 5' and 3' ends of human genes links R-loop formation to epigenetic regulation and transcription termination
- (2013) P. A. Ginno et al. GENOME RESEARCH
- R Loops Are Linked to Histone H3 S10 Phosphorylation and Chromatin Condensation
- (2013) Maikel Castellano-Pozo et al. MOLECULAR CELL
- Causes and consequences of replication stress
- (2013) Michelle K. Zeman et al. NATURE CELL BIOLOGY
- A direct role for small non-coding RNAs in DNA damage response
- (2013) Fabrizio d’Adda di Fagagna TRENDS IN CELL BIOLOGY
- Chromosome Translocation, B Cell Lymphoma, and Activation-Induced Cytidine Deaminase
- (2012) Davide F. Robbiani et al. Annual Review of Pathology-Mechanisms of Disease
- A Role for Small RNAs in DNA Double-Strand Break Repair
- (2012) Wei Wei et al. CELL
- Mechanisms for recurrent and complex human genomic rearrangements
- (2012) Pengfei Liu et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Senataxin, Defective in the Neurodegenerative Disorder Ataxia with Oculomotor Apraxia 2, Lies at the Interface of Transcription and the DNA Damage Response
- (2012) O. Yuce et al. MOLECULAR AND CELLULAR BIOLOGY
- R-Loop Formation Is a Distinctive Characteristic of Unmethylated Human CpG Island Promoters
- (2012) Paul A. Ginno et al. MOLECULAR CELL
- R Loops: From Transcription Byproducts to Threats to Genome Stability
- (2012) Andrés Aguilera et al. MOLECULAR CELL
- Site-specific DICER and DROSHA RNA products control the DNA-damage response
- (2012) Sofia Francia et al. NATURE
- Diseases Associated with Defective Responses to DNA Damage
- (2012) M. O'Driscoll Cold Spring Harbor Perspectives in Biology
- The Replication Checkpoint Protects Fork Stability by Releasing Transcribed Genes from Nuclear Pores
- (2011) Rodrigo Bermejo et al. CELL
- Linking RNA Polymerase Backtracking to Genome Instability in E. coli
- (2011) Dipak Dutta et al. CELL
- ATM activation in the presence of oxidative stress
- (2011) Zhi Guo et al. CELL CYCLE
- Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles
- (2011) Belén Gómez-González et al. EMBO JOURNAL
- R-loop-mediated genomic instability is caused by impairment of replication fork progression
- (2011) W. Gan et al. GENES & DEVELOPMENT
- Collisions between Replication and Transcription Complexes Cause Common Fragile Site Instability at the Longest Human Genes
- (2011) Anne Helmrich et al. MOLECULAR CELL
- Yeast Sen1 Helicase Protects the Genome from Transcription-Associated Instability
- (2011) Hannah E. Mischo et al. MOLECULAR CELL
- Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination
- (2011) Konstantina Skourti-Stathaki et al. MOLECULAR CELL
- Genome Instability and Transcription Elongation Impairment in Human Cells Depleted of THO/TREX
- (2011) María S. Domínguez-Sánchez et al. PLoS Genetics
- ATM-Dependent Chromatin Changes Silence Transcription In cis to DNA Double-Strand Breaks
- (2010) Niraj M. Shanbhag et al. CELL
- Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis
- (2010) A. El Hage et al. GENES & DEVELOPMENT
- ATR: a master conductor of cellular responses to DNA replication stress
- (2010) Rachel Litman Flynn et al. TRENDS IN BIOCHEMICAL SCIENCES
- The S-phase checkpoint: targeting the replication fork
- (2009) Mónica Segurado et al. BIOLOGY OF THE CELL
- Ribonuclease H: the enzymes in eukaryotes
- (2009) Susana M. Cerritelli et al. FEBS Journal
- Functional role for senataxin, defective in ataxia oculomotor apraxia type 2, in transcriptional regulation
- (2009) Amila Suraweera et al. HUMAN MOLECULAR GENETICS
- The S-Phase Checkpoint Is Required To Respond to R-Loops Accumulated in THO Mutants
- (2009) B. Gomez-Gonzalez et al. MOLECULAR AND CELLULAR BIOLOGY
- Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription
- (2009) Sandie Tuduri et al. NATURE CELL BIOLOGY
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