A molecular switch modulates assembly and host factor binding of the HIV-1 capsid

HIV Capsid and Integration Targeting

(2021) Alan N. Engelman   Viruses-Basel

A lysine ring in HIV capsid pores coordinates IP6 to drive mature capsid assembly

(2021) Nadine Renner et al.   PLoS Pathogens

Sec24C is an HIV-1 host dependency factor crucial for virus replication

(2021) Stephanie V. Rebensburg et al.   Nature Microbiology

HIV-1 capsid exploitation of the host microtubule cytoskeleton during early infection

(2021) Mojgan H. Naghavi   Retrovirology

HIV-1 capsid is the key orchestrator of early viral replication

(2021) Vojtech Zila et al.   PLoS Pathogens

Structure of native HIV-1 cores and their interactions with IP6 and CypA

(2021) Tao Ni et al.   Science Advances

Clinical targeting of HIV capsid protein with a long-acting small molecule

(2020) John O. Link et al.   NATURE

Cryo-EM analysis of a membrane protein embedded in the liposome

(2020) Xia Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV ‐1 capsids mimic a microtubule regulator to coordinate early stages of infection

(2020) Eveline Santos da Silva et al.   EMBO JOURNAL

Reconstitution and visualization of HIV-1 capsid-dependent replication and integration in vitro

(2020) Devin E. Christensen et al.   SCIENCE

A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model

(2019) Stephen R. Yant et al.   NATURE MEDICINE

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

(2019) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

Nup153 Unlocks the Nuclear Pore Complex for HIV-1 Nuclear Translocation in Non-dividing Cells

(2018) Cindy Buffone et al.   JOURNAL OF VIROLOGY

IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis

(2018) Donna L Mallery et al.   eLife

Inositol phosphates are assembly co-factors for HIV-1

(2018) Robert A. Dick et al.   NATURE

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

A dynamic hydrophobic core orchestrates allostery in protein kinases

(2017) Jonggul Kim et al.   Science Advances

The structure and flexibility of conical HIV-1 capsids determined within intact virions

(2016) Simone Mattei et al.   SCIENCE

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability

(2015) A. T. Gres et al.   SCIENCE

Structural basis of HIV-1 capsid recognition by PF74 and CPSF6

(2014) Akash Bhattacharya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-throughput profiling of point mutations across the HIV-1 genome

(2014) Laith Q Al-Mawsawi et al.   Retrovirology

A model for cofactor use during HIV-1 reverse transcription and nuclear entry

(2014) Laura Hilditch et al.   Current Opinion in Virology

Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly

(2014) Amanda J. Price et al.   PLoS Pathogens

Virus Assembly and Maturation: Auto-Regulation through Allosteric Molecular Switches

(2013) Tatiana Domitrovic et al.   JOURNAL OF MOLECULAR BIOLOGY

Fitness Costs of Mutations at the HIV-1 Capsid Hexamerization Interface

(2013) Siriphan Manocheewa et al.   PLoS One

Extreme Genetic Fragility of the HIV-1 Capsid

(2013) Suzannah J. Rihn et al.   PLoS Pathogens

Nucleoporin NUP153 Phenylalanine-Glycine Motifs Engage a Common Binding Pocket within the HIV-1 Capsid Protein to Mediate Lentiviral Infectivity

(2013) Kenneth A. Matreyek et al.   PLoS Pathogens

Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein

(2012) C. T. Lemke et al.   JOURNAL OF VIROLOGY

HIV-1 Capsid-Targeting Domain of Cleavage and Polyadenylation Specificity Factor 6

(2012) K. Lee et al.   JOURNAL OF VIROLOGY

CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication

(2012) Amanda J. Price et al.   PLoS Pathogens

The Evolution of Protein Kinase Inhibitors from Antagonists to Agonists of Cellular Signaling

(2011) Arvin C. Dar et al.   Annual Review of Biochemistry

Atomic-level modelling of the HIV capsid

(2011) Owen Pornillos et al.   NATURE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Virus assembly, allostery and antivirals

(2010) Adam Zlotnick et al.   TRENDS IN MICROBIOLOGY

HIV Capsid is a Tractable Target for Small Molecule Therapeutic Intervention

(2010) Wade S. Blair et al.   PLoS Pathogens

X-Ray Structures of the Hexameric Building Block of the HIV Capsid

(2009) Owen Pornillos et al.   CELL

Characterization of the In Vitro HIV-1 Capsid Assembly Pathway

(2009) Eric Barklis et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure and assembly of immature HIV

(2009) J. A. G. Briggs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA