Prediction of prime editing insertion efficiencies using sequence features and DNA repair determinants

Prediction of prime editing insertion efficiencies using sequence features and DNA repair determinants

(2023) Jonas Koeppel et al.   NATURE BIOTECHNOLOGY

CRISPR-based genome editing through the lens of DNA repair

(2022) Tarun S. Nambiar et al.   MOLECULAR CELL

Saturation variant interpretation using CRISPR prime editing

(2022) Steven Erwood et al.   NATURE BIOTECHNOLOGY

Prime editing efficiency and fidelity are enhanced in the absence of mismatch repair

(2022) J. Ferreira da Silva et al.   Nature Communications

Efficient targeted insertion of large DNA fragments without DNA donors

(2022) Jinlin Wang et al.   NATURE METHODS

Predicting base editing outcomes using position-specific sequence determinants

(2022) Ananth Pallaseni et al.   NUCLEIC ACIDS RESEARCH

Enhancing prime editing efficiency by modified pegRNA with RNA G-quadruplexes

(2022) Xiangyang Li et al.   Journal of Molecular Cell Biology

Highly efficient prime editing by introducing same-sense mutations in pegRNA or stabilizing its structure

(2022) Xiaosa Li et al.   Nature Communications

Enhancement of prime editing via xrRNA motif-joined pegRNA

(2022) Guiquan Zhang et al.   Nature Communications

A time-resolved, multi-symbol molecular recorder via sequential genome editing

(2022) Junhong Choi et al.   NATURE

Designing and executing prime editing experiments in mammalian cells

(2022) Jordan L. Doman et al.   Nature Protocols

Targeted genomic translocations and inversions generated using a paired prime editing strategy

(2022) Jiyeon Kweon et al.   MOLECULAR THERAPY

Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases

(2022) Matthew T. N. Yarnall et al.   NATURE BIOTECHNOLOGY

Prime editing for precise and highly versatile genome manipulation

(2022) Peter J. Chen et al.   NATURE REVIEWS GENETICS

Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide

(2021) Max Jan et al.   Science Translational Medicine

Engineered prime editors with PAM flexibility

(2021) Jiyeon Kweon et al.   MOLECULAR THERAPY

Chromothripsis as an on-target consequence of CRISPR–Cas9 genome editing

(2021) Mitchell L. Leibowitz et al.   NATURE GENETICS

Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice

(2021) Pengpeng Liu et al.   Nature Communications

Prime editing – an update on the field

(2021) Janine Scholefield et al.   GENE THERAPY

Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids

(2021) Maarten H Geurts et al.   Life Science Alliance

Enhanced prime editing systems by manipulating cellular determinants of editing outcomes

(2021) Peter J. Chen et al.   CELL

The CRISPR-Cas toolbox and gene editing technologies

(2021) Guanwen Liu et al.   MOLECULAR CELL

Deletion and replacement of long genomic sequences using prime editing

(2021) Tingting Jiang et al.   NATURE BIOTECHNOLOGY

Engineered pegRNAs improve prime editing efficiency

(2021) James W. Nelson et al.   NATURE BIOTECHNOLOGY

Precise genomic deletions using paired prime editing

(2021) Junhong Choi et al.   NATURE BIOTECHNOLOGY

Programmable deletion, replacement, integration and inversion of large DNA sequences with twin prime editing

(2021) Andrew V. Anzalone et al.   NATURE BIOTECHNOLOGY

Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs

(2020) Marco Jost et al.   NATURE BIOTECHNOLOGY

Efficient generation of mouse models with the prime editing system

(2020) Yao Liu et al.   Cell Discovery

Determinants of Base Editing Outcomes from Target Library Analysis and Machine Learning

(2020) Mandana Arbab et al.   CELL

Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors

(2020) Andrew V. Anzalone et al.   NATURE BIOTECHNOLOGY

Sequence-specific prediction of the efficiencies of adenine and cytosine base editors

(2020) Myungjae Song et al.   NATURE BIOTECHNOLOGY

Predicting the efficiency of prime editing guide RNAs in human cells

(2020) Hui Kwon Kim et al.   NATURE BIOTECHNOLOGY

Prime editing for functional repair in patient-derived disease models

(2020) Imre F. Schene et al.   Nature Communications

Search-and-replace genome editing without double-strand breaks or donor DNA

(2019) Andrew V. Anzalone et al.   NATURE

SpCas9 activity prediction by DeepSpCas9, a deep learning–based model with high generalization performance

(2019) Hui Kwon Kim et al.   Science Advances

Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements

(2018) Michael Kosicki et al.   NATURE BIOTECHNOLOGY

Predicting the mutations generated by repair of Cas9-induced double-strand breaks

(2018) Felicity Allen et al.   NATURE BIOTECHNOLOGY

GUIDES: sgRNA design for loss-of-function screens

(2017) Joshua A Meier et al.   NATURE METHODS

ClinVar: improving access to variant interpretations and supporting evidence

(2017) Melissa J Landrum et al.   NUCLEIC ACIDS RESEARCH

Improved split fluorescent proteins for endogenous protein labeling

(2017) Siyu Feng et al.   Nature Communications

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

Transcription Termination: Variations on Common Themes

(2016) Odil Porrua et al.   TRENDS IN GENETICS

ELM 2016—data update and new functionality of the eukaryotic linear motif resource

(2015) Holger Dinkel et al.   NUCLEIC ACIDS RESEARCH

ClinVar: public archive of interpretations of clinically relevant variants

(2015) Melissa J. Landrum et al.   NUCLEIC ACIDS RESEARCH

Transcription Activator-Like Effector Nuclease (TALEN)-Mediated CLYBL Targeting Enables Enhanced Transgene Expression and One-Step Generation of Dual Reporter Human Induced Pluripotent Stem Cell (iPSC) and Neural Stem Cell (NSC) Lines

(2015) Trevor Cerbini et al.   PLoS One

Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System

(2013) Baohui Chen et al.   CELL

The eukaryotic linear motif resource ELM: 10 years and counting

(2013) Holger Dinkel et al.   NUCLEIC ACIDS RESEARCH

Genetic Variation and Clinical Heterogeneity in Cystic Fibrosis

(2011) Mitchell L. Drumm et al.   Annual Review of Pathology-Mechanisms of Disease

Mechanism of mismatch recognition revealed by human MutSβ bound to unpaired DNA loops

(2011) Shikha Gupta et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A hyperactive piggyBac transposase for mammalian applications

(2011) K. Yusa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Vienna RNA Websuite

(2008) A. R. Gruber et al.   NUCLEIC ACIDS RESEARCH