Efficient evolution of human antibodies from general protein language models
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Title
Efficient evolution of human antibodies from general protein language models
Authors
Keywords
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Journal
NATURE BIOTECHNOLOGY
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2023-04-25
DOI
10.1038/s41587-023-01763-2
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- (2022) Gabriel D. Victora et al. Annual Review of Immunology
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- (2022) Sisi Shan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Evolution and Biology of SARS-CoV-2 Variants
- (2022) Amalio Telenti et al. Cold Spring Harbor Perspectives in Medicine
- Evolution of antibody immunity to SARS-CoV-2
- (2021) Christian Gaebler et al. NATURE
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- Low-N protein engineering with data-efficient deep learning
- (2021) Surojit Biswas et al. NATURE METHODS
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- (2021) Alexander Rives et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2021) Derek M. Mason et al. Nature Biomedical Engineering
- Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations
- (2021) Frauke Muecksch et al. IMMUNITY
- Rapid generation of potent antibodies by autonomous hypermutation in yeast
- (2021) Alon Wellner et al. Nature Chemical Biology
- Revealing enzyme functional architecture via high-throughput microfluidic enzyme kinetics
- (2021) C. J. Markin et al. SCIENCE
- Informed training set design enables efficient machine learning-assisted directed protein evolution
- (2021) Bruce J. Wittmann et al. Cell Systems
- Learning the protein language: Evolution, structure, and function
- (2021) Tristan Bepler et al. Cell Systems
- Adaptive machine learning for protein engineering
- (2021) Brian L. Hie et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Observed Antibody Space: A diverse database of cleaned, annotated, and translated unpaired and paired antibody sequences
- (2021) Tobias H. Olsen et al. PROTEIN SCIENCE
- Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody
- (2020) Dora Pinto et al. NATURE
- NetMHCpan-4.1 and NetMHCIIpan-4.0: improved predictions of MHC antigen presentation by concurrent motif deconvolution and integration of MS MHC eluted ligand data
- (2020) Birkir Reynisson et al. NUCLEIC ACIDS RESEARCH
- Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays
- (2020) Katharine H. D. Crawford et al. Viruses-Basel
- Using deep mutational scanning to benchmark variant effect predictors and identify disease mutations
- (2020) Benjamin J Livesey et al. Molecular Systems Biology
- Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model
- (2020) Thomas F. Rogers et al. SCIENCE
- Structure-based design of prefusion-stabilized SARS-CoV-2 spikes
- (2020) Ching-Lin Hsieh et al. SCIENCE
- Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail
- (2020) Johanna Hansen et al. SCIENCE
- CoV-AbDab: the Coronavirus Antibody Database
- (2020) Matthew I J Raybould et al. BIOINFORMATICS
- Structural and functional characterization of G protein-coupled receptors with deep mutational scanning
- (2020) Eric M Jones et al. eLife
- Leveraging Uncertainty in Machine Learning Accelerates Biological Discovery and Design
- (2020) Brian Hie et al. Cell Systems
- Machine-learning-guided directed evolution for protein engineering
- (2019) Kevin K. Yang et al. NATURE METHODS
- A Probabilistic Model of the Germinal Center Reaction
- (2019) Marcel Jan Thomas et al. Frontiers in Immunology
- Thera-SAbDab: the Therapeutic Structural Antibody Database
- (2019) Matthew I J Raybould et al. NUCLEIC ACIDS RESEARCH
- Unified rational protein engineering with sequence-based deep representation learning
- (2019) Ethan C. Alley et al. NATURE METHODS
- Mutational processes shape the landscape of TP53 mutations in human cancer
- (2018) Andrew O. Giacomelli et al. NATURE GENETICS
- Deep mutational scanning of hemagglutinin helps predict evolutionary fates of human H3N2 influenza variants
- (2018) Juhye M. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- abYsis: Integrated Antibody Sequence and Structure—Management, Analysis, and Prediction
- (2017) Mark B. Swindells et al. JOURNAL OF MOLECULAR BIOLOGY
- Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes
- (2016) Nicole L. Kallewaard et al. CELL
- Mastering the game of Go with deep neural networks and tree search
- (2016) David Silver et al. NATURE
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- (2016) D. Corti et al. SCIENCE
- Visualizing antibody affinity maturation in germinal centers
- (2016) J. M. J. Tas et al. SCIENCE
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- (2016) Michael Doud et al. Viruses-Basel
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- (2016) Lisa Brenan et al. Cell Reports
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- Deep mutational scanning: a new style of protein science
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- (2013) K. Katoh et al. MOLECULAR BIOLOGY AND EVOLUTION
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- ABangle: characterising the VH-VL orientation in antibodies
- (2013) J. Dunbar et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective
- (2010) Olga Khersonsky and Dan S. Tawfik Annual Review of Biochemistry
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