Polygenic scoring accuracy varies across the genetic ancestry continuum

Portability of 245 polygenic scores when derived from the UK Biobank and applied to 9 ancestry groups from the same cohort

(2022) Florian Privé et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A roadmap to increase diversity in genomic studies

(2022) Segun Fatumo et al.   NATURE MEDICINE

Improving polygenic prediction in ancestrally diverse populations

(2022) Yunfeng Ruan et al.   NATURE GENETICS

Polygenic scores in biomedical research

(2022) Iftikhar J. Kullo et al.   NATURE REVIEWS GENETICS

Genetic ancestry in precision medicine is reshaping the race debate

(2022) Talia Krainc et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Getting genetic ancestry right for science and society

(2022) Anna C. F. Lewis et al.   SCIENCE

Race and Ethnicity Stratification for Polygenic Risk Score Analyses May Mask Disparities in Hispanics

(2022) Shoa L. Clarke et al.   CIRCULATION

Increasing diversity in genomics requires investment in equitable partnerships and capacity building

(2022) Alicia R. Martin et al.   NATURE GENETICS

Leveraging genomic diversity for discovery in an electronic health record linked biobank: the UCLA ATLAS Community Health Initiative

(2022) Ruth Johnson et al.   Genome Medicine

Toward a fine-scale population health monitoring system

(2021) Gillian M. Belbin et al.   CELL

Improved genetic prediction of complex traits from individual-level data or summary statistics

(2021) Qianqian Zhang et al.   Nature Communications

Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification

(2021) Yi Ding et al.   NATURE GENETICS

Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps

(2021) et al.   NATURE MEDICINE

Variable prediction accuracy of polygenic scores within an ancestry group

(2020) Hakhamanesh Mostafavi et al.   eLife

Validating Breast Cancer Risk Prediction Models in the Korean Cancer Prevention Study-II Biobank

(2020) Yon Ho Jee et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Electronic health records and polygenic risk scores for predicting disease risk

(2020) Ruowang Li et al.   NATURE REVIEWS GENETICS

What is ancestry?

(2020) Iain Mathieson et al.   PLoS Genetics

Using Monte Carlo method to include polygenic effects in calculation of SNP-BLUP model reliability

(2020) H. Ben Zaabza et al.   JOURNAL OF DAIRY SCIENCE

Efficient polygenic risk scores for biobank scale data by exploiting phenotypes from inferred relatives

(2020) Buu Truong et al.   Nature Communications

Polygenic Scores for Height in Admixed Populations

(2020) Bárbara D. Bitarello et al.   G3-Genes Genomes Genetics

LDpred2: better, faster, stronger

(2020) Florian Privé et al.   BIOINFORMATICS

BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors

(2019) Andrew Lee et al.   GENETICS IN MEDICINE

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood

(2019) Amit V. Khera et al.   CELL

Genetic analyses of diverse populations improves discovery for complex traits

(2019) Genevieve L. Wojcik et al.   NATURE

Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture

(2019) Kangcheng Hou et al.   NATURE GENETICS

Atherosclerotic Cardiovascular Disease Risk Prediction in Disaggregated Asian and Hispanic Subgroups Using Electronic Health Records

(2019) Fatima Rodriguez et al.   Journal of the American Heart Association

Towards clinical utility of polygenic risk scores

(2019) Samuel A Lambert et al.   HUMAN MOLECULAR GENETICS

Polygenic Risk Score Contribution to Psychosis Prediction in a Target Population of Persons at Clinical High Risk

(2019) Diana O. Perkins et al.   AMERICAN JOURNAL OF PSYCHIATRY

Improved polygenic prediction by Bayesian multiple regression on summary statistics

(2019) Luke R. Lloyd-Jones et al.   Nature Communications

Efficient analysis of large-scale genome-wide data with two R packages: bigstatsr and bigsnpr

(2018) Florian Privé et al.   BIOINFORMATICS

The personal and clinical utility of polygenic risk scores

(2018) Ali Torkamani et al.   NATURE REVIEWS GENETICS

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

Using Genetic Distance to Infer the Accuracy of Genomic Prediction

(2016) Marco Scutari et al.   PLoS Genetics

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Fast Principal Component Analysis of Large-Scale Genome-Wide Data

(2014) Gad Abraham et al.   PLoS One

Pitfalls of predicting complex traits from SNPs

(2013) Naomi R. Wray et al.   NATURE REVIEWS GENETICS

The Effect of Linkage Disequilibrium and Family Relationships on the Reliability of Genomic Prediction

(2012) Y. C. J. Wientjes et al.   GENETICS

Enhancements to the ADMIXTURE algorithm for individual ancestry estimation

(2011) David H Alexander et al.   BMC BIOINFORMATICS

Using the genomic relationship matrix to predict the accuracy of genomic selection

(2011) M.E. Goddard et al.   JOURNAL OF ANIMAL BREEDING AND GENETICS

Reliability of direct genomic values for animals with different relationships within and to the reference population

(2011) M. Pszczola et al.   JOURNAL OF DAIRY SCIENCE

Common SNPs explain a large proportion of the heritability for human height

(2010) Jian Yang et al.   NATURE GENETICS

A Commentary on ‘Common SNPs Explain a Large Proportion of the Heritability for Human Height’ by Yang et al. (2010)

(2010) Peter M. Visscher et al.   Twin Research and Human Genetics

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Reduced Neutrophil Count in People of African Descent Is Due To a Regulatory Variant in the Duffy Antigen Receptor for Chemokines Gene

(2009) David Reich et al.   PLoS Genetics

Genomic selection: prediction of accuracy and maximisation of long term response

(2008) Mike Goddard   GENETICA

Efficient Methods to Compute Genomic Predictions

(2008) P.M. VanRaden   JOURNAL OF DAIRY SCIENCE

Accuracy of Predicting the Genetic Risk of Disease Using a Genome-Wide Approach

(2008) Hans D. Daetwyler et al.   PLoS One

The impact of genetic relationship information on genome-assisted breeding values

(2007) D. Habier et al.   GENETICS