RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer

An atlas of substrate specificities for the human serine/threonine kinome

(2023) Jared L. Johnson et al.   NATURE

The Match between Molecular Subtypes, Histology and Microenvironment of Pancreatic Cancer and Its Relevance for Chemoresistance

(2021) Javier Martinez-Useros et al.   Cancers

MYH9-dependent polarization of ATG9B promotes colorectal cancer metastasis by accelerating focal adhesion assembly

(2021) Yan Zhong et al.   CELL DEATH AND DIFFERENTIATION

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

RBFOX2 alters splicing outcome in distinct binding modes with multiple protein partners

(2021) Delong Zhou et al.   NUCLEIC ACIDS RESEARCH

Paxillin promotes breast tumor collective cell invasion through maintenance of adherens junction integrity

(2021) Weiyi Xu et al.   MOLECULAR BIOLOGY OF THE CELL

AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models

(2021) Mihaly Varadi et al.   NUCLEIC ACIDS RESEARCH

Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution

(2020) Michelle Chan-Seng-Yue et al.   NATURE GENETICS

Concentration-dependent splicing is enabled by Rbfox motifs of intermediate affinity

(2020) Bridget E. Begg et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TGF-β-induced alternative splicing of TAK1 promotes EMT and drug resistance

(2019) Veenu Tripathi et al.   ONCOGENE

Integration of Genomic and Transcriptional Features in Pancreatic Cancer Reveals Increased Cell Cycle Progression in Metastases

(2019) Ashton A. Connor et al.   CANCER CELL

PSI-Sigma: a comprehensive splicing-detection method for short-read and long-read RNA-seq analysis

(2019) Kuan-Ting Lin et al.   BIOINFORMATICS

CHOPCHOP v3: expanding the CRISPR web toolbox beyond genome editing

(2019) Kornel Labun et al.   NUCLEIC ACIDS RESEARCH

Microtubules at focal adhesions – a double-edged sword

(2019) Shailaja Seetharaman et al.   JOURNAL OF CELL SCIENCE

Recapitulating the clinical scenario of BRCA-associated pancreatic cancer in pre-clinical models

(2018) Talia Golan et al.   INTERNATIONAL JOURNAL OF CANCER

rbFOX1/MBNL1 competition for CCUG RNA repeats binding contributes to myotonic dystrophy type 1/type 2 differences

(2018) Chantal Sellier et al.   Nature Communications

Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer

(2017) Tessa Humphries-Bickley et al.   MOLECULAR CANCER THERAPEUTICS

Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer

(2017) Alvin P Makohon-Moore et al.   NATURE GENETICS

Pancreatic cancer ascites xenograft–an expeditious model mirroring advanced therapeutic resistant disease

(2017) Talia Golan et al.   Oncotarget

Splice variants as novel targets in pancreatic ductal adenocarcinoma

(2017) Jun Wang et al.   Scientific Reports

Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma

(2017) Ashton A. Connor et al.   JAMA Oncology

Rbfox Proteins Regulate Splicing as Part of a Large Multiprotein Complex LASR

(2016) Andrey Damianov et al.   CELL

Genomic analyses identify molecular subtypes of pancreatic cancer

(2016) Peter Bailey et al.   NATURE

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma

(2015) Richard A Moffitt et al.   NATURE GENETICS

The MEME Suite

(2015) Timothy L. Bailey et al.   NUCLEIC ACIDS RESEARCH

Pancreatic Adenocarcinoma

(2015) David P. Ryan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

The RNA-binding protein Rbfox2: an essential regulator of EMT-driven alternative splicing and a mediator of cellular invasion

(2013) C Braeutigam et al.   ONCOGENE

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

The splicing factor SRSF6 is amplified and is an oncoprotein in lung and colon cancers

(2012) Michal Cohen-Eliav et al.   JOURNAL OF PATHOLOGY

RBFOX2 Is an Important Regulator of Mesenchymal Tissue-Specific Splicing in both Normal and Cancer Tissues

(2012) J. P. Venables et al.   MOLECULAR AND CELLULAR BIOLOGY

Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

(2011) Eric A Collisson et al.   NATURE MEDICINE

Distant metastasis occurs late during the genetic evolution of pancreatic cancer

(2010) Shinichi Yachida et al.   NATURE

Cell adhesion: integrating cytoskeletal dynamics and cellular tension

(2010) J. Thomas Parsons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Characterization of Alternative Spliceoforms and the RNA Splicing Machinery in Pancreatic Cancer

(2010) Patricia E. Carrigan et al.   PANCREAS

Cancer-associated regulation of alternative splicing

(2009) Julian P Venables et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE