Non-invasive PTEN mRNA brain delivery effectively mitigates growth of orthotopic glioblastoma

Brain-Targeted Codelivery of Bcl-2/Bcl-xl and Mcl-1 Inhibitors by Biomimetic Nanoparticles for Orthotopic Glioblastoma Therapy

(2022) Wenya He et al.   ACS Nano

Blood-brain barrier–penetrating single CRISPR-Cas9 nanocapsules for effective and safe glioblastoma gene therapy

(2022) Yan Zou et al.   Science Advances

Brain‐Targeting Metastatic Tumor Cell Membrane Cloaked Biomimetic Nanomedicines Mediate Potent Chemodynamic and RNAi Combinational Therapy of Glioblastoma

(2022) Dongya Zhang et al.   ADVANCED FUNCTIONAL MATERIALS

Coagulation-Inspired Direct Fibrinogen Assay Using Plasmonic Nanoparticles Functionalized with Red Blood Cell Membranes

(2021) Insu Kim et al.   ACS Nano

Self-assembled mRNA vaccines

(2021) Jeonghwan Kim et al.   ADVANCED DRUG DELIVERY REVIEWS

Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR–Cas gene editing

(2021) Shuai Liu et al.   NATURE MATERIALS

Immunogenicity of a Single Dose of SARS-CoV-2 Messenger RNA Vaccine in Solid Organ Transplant Recipients

(2021) Brian J. Boyarsky et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Selective transferrin coating as a facile strategy to fabricate BBB-permeable and targeted vesicles for potent RNAi therapy of brain metastatic breast cancer in vivo

(2021) Yaohua Wei et al.   JOURNAL OF CONTROLLED RELEASE

Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models

(2021) Yao-Xin Lin et al.   Science Translational Medicine

Intracranial delivery of synthetic mRNA to suppress glioblastoma

(2021) Hao Peng et al.   Molecular Therapy-Oncolytics

Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle

(2020) Prakash Dharmalingam et al.   ACS Nano

Charge Conversional Biomimetic Nanocomplexes as a Multifunctional Platform for Boosting Orthotopic Glioblastoma RNAi Therapy

(2020) Yanjie Liu et al.   NANO LETTERS

Deconvoluting Lipid Nanoparticle Structure for Messenger RNA Delivery

(2020) Yulia Eygeris et al.   NANO LETTERS

Translational Nanomedicine Boosts Anti-PD1 Therapy to Eradicate Orthotopic PTEN-Negative Glioblastoma

(2020) Hiroaki Kinoh et al.   ACS Nano

Management of glioblastoma: State of the art and future directions

(2020) Aaron C. Tan et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Recent advances in mRNA vaccine technology

(2020) Norbert Pardi et al.   CURRENT OPINION IN IMMUNOLOGY

E2F7−EZH2 axis regulates PTEN/AKT/mTOR signalling and glioblastoma progression

(2020) Rui Yang et al.   BRITISH JOURNAL OF CANCER

Adeno-associated virus vector as a platform for gene therapy delivery

(2019) Dan Wang et al.   NATURE REVIEWS DRUG DISCOVERY

Carriers Break Barriers in Drug Delivery: Endocytosis and Endosomal Escape of Gene Delivery Vectors

(2019) Isabelle M. S. Degors et al.   ACCOUNTS OF CHEMICAL RESEARCH

Fast and Efficient CRISPR/Cas9 Genome Editing In Vivo Enabled by Bioreducible Lipid and Messenger RNA Nanoparticles

(2019) Ji Liu et al.   ADVANCED MATERIALS

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

(2019) Cyril Neftel et al.   CELL

LRP1-upregulated nanoparticles for efficiently conquering the blood-brain barrier and targetedly suppressing multifocal and infiltrative brain metastases

(2019) Qian Guo et al.   JOURNAL OF CONTROLLED RELEASE

Chemical modulation of siRNA lipophilicity for efficient delivery

(2019) Wanyi Tai   JOURNAL OF CONTROLLED RELEASE

Three decades of messenger RNA vaccine development

(2019) Rein Verbeke et al.   Nano Today

Molecular targeted therapy of glioblastoma

(2019) Emilie Le Rhun et al.   CANCER TREATMENT REVIEWS

Gradient Redox-Responsive and Two-Stage Rocket-Mimetic Drug Delivery System for Improved Tumor Accumulation and Safe Chemotherapy

(2019) Xiaobo Jia et al.   NANO LETTERS

RNA therapies explained

(2019) Sarah DeWeerdt   NATURE

Red blood cell–derived nanoerythrosome for antigen delivery with enhanced cancer immunotherapy

(2019) Xiao Han et al.   Science Advances

Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition

(2019) Na Kong et al.   Science Translational Medicine

MiR-132 controls pancreatic beta cell proliferation and survival through Pten/Akt/Foxo3 signaling

(2019) Hassan Mziaut et al.   Molecular Metabolism

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

(2019) Zhaogang Yang et al.   Nature Biomedical Engineering

Endosomal Size and Membrane Leakiness Influence Proton Sponge-Based Rupture of Endosomal Vesicles

(2018) Lotte M. P. Vermeulen et al.   ACS Nano

PTBP1 promotes the growth of breast cancer cells through the PTEN/Akt pathway and autophagy

(2018) Xu Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Drug delivery challenges and future of chemotherapeutic nanomedicine for glioblastoma treatment

(2018) Lakshmi Pallavi Ganipineni et al.   JOURNAL OF CONTROLLED RELEASE

Crossing the blood-brain barrier with nanoparticles

(2018) Yiqun Zhou et al.   JOURNAL OF CONTROLLED RELEASE

Design of an Amphiphilic iRGD Peptide and Self-Assembling Nanovesicles for Improving Tumor Accumulation and Penetration and the Photodynamic Efficacy of the Photosensitizer

(2018) Yue Jiang et al.   ACS Applied Materials & Interfaces

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing

(2018) Barry Boland et al.   NATURE REVIEWS DRUG DISCOVERY

Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA

(2018) Mohammad Ariful Islam et al.   Nature Biomedical Engineering

Apolipoprotein E Peptide-Directed Chimeric Polymersomes Mediate an Ultrahigh-Efficiency Targeted Protein Therapy for Glioblastoma

(2018) Yu Jiang et al.   ACS Nano

Biomimetic ApoE-Reconstituted High Density Lipoprotein Nanocarrier for Blood–Brain Barrier Penetration and Amyloid Beta-Targeting Drug Delivery

(2016) Qingxiang Song et al.   MOLECULAR PHARMACEUTICS

Phenylboronic Acid-Decorated Chondroitin Sulfate A-Based Theranostic Nanoparticles for Enhanced Tumor Targeting and Penetration

(2015) Jae-Young Lee et al.   ADVANCED FUNCTIONAL MATERIALS

Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs

(2015) Kevin J. Kauffman et al.   NANO LETTERS

Brain disorders? Precisely

(2015) T. R. Insel et al.   SCIENCE

Interfacial interactions between natural RBC membranes and synthetic polymeric nanoparticles

(2013) Brian T. Luk et al.   Nanoscale

Engineering a lysosomal enzyme with a derivative of receptor-binding domain of apoE enables delivery across the blood-brain barrier

(2013) D. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

(2012) Hyukjin Lee et al.   Nature Nanotechnology

PTEN Signaling pathways in glioblastoma

(2010) Dimpy Koul   CANCER BIOLOGY & THERAPY

High performance mRNA transfection through carbonate apatite–cationic liposome conjugates

(2009) Fatema T. Zohra et al.   BIOMATERIALS

Alphaviruses in Gene Therapy

(2009) Kenneth Lundstrom   Viruses-Basel