Development of 18F-Labeled Acridone Analogue for Tumor Imaging via Stimulator of Interferon Genes Targeting

Activation of STING by targeting a pocket in the transmembrane domain

(2022) Defen Lu et al.   NATURE

18F-FDG PET visualizes systemic STING agonist-induced lymphocyte activation in preclinical models

(2022) Thuc M. Le et al.   JOURNAL OF NUCLEAR MEDICINE

Development of A Novel Radiofluorinated Riboflavin Probe for Riboflavin Receptor-Targeting PET Imaging

(2022) Jindian Li et al.   PHARMACOLOGICAL RESEARCH

A novel 18F-labeled agonist for PET imaging of stimulator of interferon gene expression in tumor-bearing mice

(2022) Jianyang Fang et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Novel STING-targeted PET radiotracer for alert and therapeutic evaluation of acute lung injury

(2022) Duo Xu et al.   Acta Pharmaceutica Sinica B

Immune Checkpoint Inhibitors for the Treatment of Bladder Cancer

(2021) Antonio Lopez-Beltran et al.   Cancers

E7766, a Macrocycle‐Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan‐Genotypic Activity

(2021) Dae‐Shik Kim et al.   ChemMedChem

Pretreatment neutrophil-to-lymphocyte ratio and mutational burden as biomarkers of tumor response to immune checkpoint inhibitors

(2021) Cristina Valero et al.   Nature Communications

Targeting Innate Immunity in Cancer Therapy

(2021) Srikrishnan Rameshbabu et al.   Vaccines

STING-driven interferon signaling triggers metabolic alterations in pancreas cancer cells visualized by [18F]FLT PET imaging

(2021) Keke Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STING Agonists as Cancer Therapeutics

(2021) Afsaneh Amouzegar et al.   Cancers

Phase I Dose-Escalation Trial of MIW815 (ADU-S100), an Intratumoral STING Agonist, in Patients with Advanced/Metastatic Solid Tumors or Lymphomas

(2021) Funda Meric-Bernstam et al.   CLINICAL CANCER RESEARCH

Development of Small-Molecule STING Activators for Cancer Immunotherapy

(2021) Hee Ra Jung et al.   Biomedicines

Imaging the cancer immune environment and its response to pharmacological intervention- Part 1- The role of FDG PET/CT

(2020) Amir Iravani et al.   JOURNAL OF NUCLEAR MEDICINE

Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy

(2020) Juyan Zheng et al.   Molecular Cancer

When STING Meets Viruses: Sensing, Trafficking and Response

(2020) Zhaohe Li et al.   Frontiers in Immunology

Challenges and Opportunities in the Clinical Development of STING Agonists for Cancer Immunotherapy

(2020) Leila Motedayen Aval et al.   Journal of Clinical Medicine

Low-dose carboplatin reprograms tumor immune microenvironment through STING signaling pathway and synergizes with PD-1 inhibitors in lung cancer

(2020) Li Zhou et al.   CANCER LETTERS

Tumor microenvironment as a therapeutic target in cancer

(2020) Yi Xiao et al.   PHARMACOLOGY & THERAPEUTICS

Discovery and Mechanistic Study of a Novel Human-Stimulator-of-Interferon-Genes Agonist

(2019) Xiaohui Zhang et al.   ACS Infectious Diseases

A 89Zr-HDL PET tracer monitors response to a CSF1R inhibitor

(2019) Christian Mason et al.   JOURNAL OF NUCLEAR MEDICINE

STING: a master regulator in the cancer-immunity cycle

(2019) Yuanyuan Zhu et al.   Molecular Cancer

Tumor microenvironment components: Allies of cancer progression

(2019) Pablo Igor Ribeiro Franco et al.   PATHOLOGY RESEARCH AND PRACTICE

Immune-related adverse events and anti-tumor efficacy of immune checkpoint inhibitors

(2019) Satya Das et al.   Journal for ImmunoTherapy of Cancer

Design, synthesis and biological evaluation of acridone analogues as novel STING receptor agonists

(2019) Shi Hou et al.   BIOORGANIC CHEMISTRY

The binding of TBK1 to STING requires exocytic membrane traffic from the ER

(2018) Emari Ogawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Can innate immune system targets turn up the heat on 'cold' tumours?

(2018) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

STINGing Antitumor Immunity into Action

(2018)   Cancer Discovery

Targeting STING with covalent small-molecule inhibitors

(2018) Simone M. Haag et al.   NATURE

Design of amidobenzimidazole STING receptor agonists with systemic activity

(2018) Joshi M. Ramanjulu et al.   NATURE

Decreased expression of STING predicts poor prognosis in patients with gastric cancer

(2017) Shushu Song et al.   Scientific Reports

Coinhibitory Pathways in Immunotherapy for Cancer

(2016) Susanne H. Baumeister et al.   Annual Review of Immunology

Programmed Death-Ligand 1 Expression and Response to the Anti–Programmed Death 1 Antibody Pembrolizumab in Melanoma

(2016) Adil I. Daud et al.   JOURNAL OF CLINICAL ONCOLOGY

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

The emerging roles of the STING adaptor protein in immunity and diseases

(2015) Xing Liu et al.   IMMUNOLOGY

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses

(2015) Tina M. Sali et al.   PLoS Pathogens

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

(2013) Pu Gao et al.   CELL

Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid

(2013) J. Conlon et al.   JOURNAL OF IMMUNOLOGY

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

How Many PET Tracers Do We Need?

(2011) M. Schwaiger et al.   JOURNAL OF NUCLEAR MEDICINE

Visualizing cancer and immune cell function with metabolic positron emission tomography

(2009) Rachel E Laing et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

18F-Labelled vorozole analogues as PET tracer for aromatase

(2008) Maria Erlandsson et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE