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Branching out in different directions: Emerging cellular functions for the Arp2/3 complex and WASP-family actin nucleation factors

(2023) Kenneth G. Campellone et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

WASP Family Proteins: Molecular Mechanisms and Implications in Human Disease

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The actin nucleation factors JMY and WHAMM enable a rapid Arp2/3 complex-mediated intrinsic pathway of apoptosis

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Apoptosome Formation through Disruption of the K192-D616 Salt Bridge in the Apaf-1 Closed Form

(2021) Fatemeh Sahebazzamani et al.   ACS Omega

Actin Assembly around the Shigella-Containing Vacuole Promotes Successful Infection

(2020) Sonja Kühn et al.   Cell Reports

Phase Separation in Membrane Biology: The Interplay between Membrane-Bound Organelles and Membraneless Condensates

(2020) Yan G. Zhao et al.   DEVELOPMENTAL CELL

The Golgi Apparatus May Be a Potential Therapeutic Target for Apoptosis-Related Neurological Diseases

(2020) Qiang He et al.   Frontiers in Cell and Developmental Biology

Complex Interactions Between Membrane-Bound Organelles, Biomolecular Condensates and the Cytoskeleton

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(2019) Thomas D. Pollard et al.   Annual Review of Biochemistry

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(2019) Rumani Singh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

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(2019) Matous Hrdinka et al.   GENES AND IMMUNITY

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(2019) Christopher Patrick Caridi et al.   NATURE CELL BIOLOGY

Mitochondria as multifaceted regulators of cell death

(2019) Florian J. Bock et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

New insights into apoptosome structure and function

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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Baculovirus Actin-Based Motility Drives Nuclear Envelope Disruption and Nuclear Egress

(2018) Taro Ohkawa et al.   CURRENT BIOLOGY

Myosin VI-Dependent Actin Cages Encapsulate Parkin-Positive Damaged Mitochondria

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Cortactin: Cell Functions of A Multifaceted Actin-Binding Protein

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The Actin Cytoskeleton and Actin-Based Motility

(2018) Tatyana Svitkina   Cold Spring Harbor Perspectives in Biology

The molecular language of membraneless organelles

(2018) Edward Gomes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LC3 and STRAP regulate actin filament assembly by JMY during autophagosome formation

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(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme

(2017) Yini Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding CARD Tricks in Apoptosomes

(2017) Li Wang et al.   STRUCTURE

Structural Insights into DD-Fold Assembly and Caspase-9 Activation by the Apaf-1 Apoptosome

(2017) Tsung-Wei Su et al.   STRUCTURE

Function and regulation of the Arp2/3 complex during cell migration in diverse environments

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(2016) Thomas D. Pollard   Cold Spring Harbor Perspectives in Biology

The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities

(2016) Chu-Chiao Wu et al.   Nature Communications

Dynamic actin cycling through mitochondrial subpopulations locally regulates the fission–fusion balance within mitochondrial networks

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A near atomic structure of the active human apoptosome

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Atomic structure of the apoptosome: mechanism of cytochromec- and dATP-mediated activation of Apaf-1

(2015) Mengying Zhou et al.   GENES & DEVELOPMENT

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(2015) Douglas R. Green et al.   Cold Spring Harbor Perspectives in Biology

JMY is involved in anterograde vesicle trafficking from the trans-Golgi network

(2014) Kai Schlüter et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

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(2014) Qi Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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Mitochondrial Regulation of Cell Death

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Structural insights into WHAMM-mediated cytoskeletal coordination during membrane remodeling

(2012) Qing-Tao Shen et al.   JOURNAL OF CELL BIOLOGY

Actin binding to WH2 domains regulates nuclear import of the multifunctional actin regulator JMY

(2012) J. Bradley Zuchero et al.   MOLECULAR BIOLOGY OF THE CELL

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(2012) Pilong Li et al.   NATURE

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(2012) Johannes Schindelin et al.   NATURE METHODS

New insights into the regulation and cellular functions of the ARP2/3 complex

(2012) Jeremy D. Rotty et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ADF/cofilin proteins translocate to mitochondria during apoptosis but are not generally required for cell death signaling

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The actin nucleation factor JMY is a negative regulator of neuritogenesis

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The Holo-Apoptosome: Activation of Procaspase-9 and Interactions with Caspase-3

(2011) Shujun Yuan et al.   STRUCTURE

Regulation of the Apaf-1-caspase-9 apoptosome

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A nucleator arms race: cellular control of actin assembly

(2010) Kenneth G. Campellone et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of an Apoptosome-Procaspase-9 CARD Complex

(2010) Shujun Yuan et al.   STRUCTURE

Spatial and Temporal Dynamics of Mitochondrial Membrane Permeability Waves during Apoptosis

(2009) Patrick D. Bhola et al.   BIOPHYSICAL JOURNAL

Dynamics of outer mitochondrial membrane permeabilization during apoptosis

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The Apaf-1•procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer

(2009) Srinivas Malladi et al.   EMBO JOURNAL

Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin

(2009) Fábio Klamt et al.   NATURE CELL BIOLOGY

p53-cofactor JMY is a multifunctional actin nucleation factor

(2009) J. Bradley Zuchero et al.   NATURE CELL BIOLOGY

A transcription co-factor integrates cell adhesion and motility with the p53 response

(2009) A. S. Coutts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

WHAMM Is an Arp2/3 Complex Activator That Binds Microtubules and Functions in ER to Golgi Transport

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Mitochondrial shuttling of CAP1 promotes actin- and cofilin-dependent apoptosis

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Modification of intracellular membrane structures for virus replication

(2008) Sven Miller et al.   NATURE REVIEWS MICROBIOLOGY