In-Depth Characterization of Apoptosis N-terminome Reveals a Link Between Caspase-3 Cleavage and Post-Translational N-terminal Acetylation

N-Acetylation of secreted proteins is widespread in Apicomplexa and independent of acetyl-CoA ER-transporter AT1

(2022) Mary Akinyi Nyonda et al.   JOURNAL OF CELL SCIENCE

Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting

(2022) Ahmad Jomaa et al.   SCIENCE

Overlap of NatA and IAP substrates implicates N-terminal acetylation in protein stabilization

(2021) Franziska Mueller et al.   Science Advances

Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling

(2021) Luam E. Araya et al.   ACS Chemical Biology

AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models

(2021) Mihaly Varadi et al.   NUCLEIC ACIDS RESEARCH

A Rapid and Easy Enrichment Strategy for Naturally Acetylated N Termini Based on LysN Digestion and Amine-reactive Resin Capture

(2020) Xiaoxian Du et al.   ANALYTICAL CHEMISTRY

Dual lysine and N‐terminal acetyltransferases reveal the complexity underpinning protein acetylation

(2020) Willy V Bienvenut et al.   Molecular Systems Biology

More than just a ticket canceller: The mitochondrial processing peptidase tailors complex precursor proteins at internal cleavage sites

(2020) Jana Friedl et al.   MOLECULAR BIOLOGY OF THE CELL

UniProt: the universal protein knowledgebase in 2021

(2020) et al.   NUCLEIC ACIDS RESEARCH

Early Scanning of Nascent Polypeptides inside the Ribosomal Tunnel by NAC

(2019) Martin Gamerdinger et al.   MOLECULAR CELL

Protease Substrate Identification Using N-terminomics

(2019) Shu Yue Luo et al.   ACS Chemical Biology

Sensitive determination of proteolytic proteoforms in limited microscale proteome samples

(2019) Samuel SH Weng et al.   MOLECULAR & CELLULAR PROTEOMICS

Proteomic and N-Terminomic TAILS Analyses of Human Alveolar Bone Proteins: Improved Protein Extraction Methodology and LysargiNase Digestion Strategies Increase Proteome Coverage and Missing Protein Identification

(2019) Peter A Bell et al.   JOURNAL OF PROTEOME RESEARCH

N-terminal acetylation: an essential protein modification emerges as an important regulator of stress responses

(2018) Eric Linster et al.   JOURNAL OF EXPERIMENTAL BOTANY

Omics Assisted N-terminal Proteoform and Protein Expression Profiling On Methionine Aminopeptidase 1 (MetAP1) Deletion

(2018) Veronique Jonckheere et al.   MOLECULAR & CELLULAR PROTEOMICS

NAA80 is actin’s N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility

(2018) Adrian Drazic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Approach to Incorporate Multi-Enzyme Digestion into C-TAILS for C-Terminomics Studies

(2017) Yang Zhang et al.   PROTEOMICS

Hydrophobic Tagging-Assisted N-Termini Enrichment for In-Depth N-Terminome Analysis

(2016) Lingfan Chen et al.   ANALYTICAL CHEMISTRY

Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues

(2016) J E Seaman et al.   CELL DEATH AND DIFFERENTIATION

Effects of peptide acetylation and dimethylation on electrospray ionization efficiency

(2016) Kyung-Cho Cho et al.   JOURNAL OF MASS SPECTROMETRY

Opposite Electron-Transfer Dissociation and Higher-Energy Collisional Dissociation Fragmentation Characteristics of Proteolytic K/R(X)n and (X)nK/R Peptides Provide Benefits for Peptide Sequencing in Proteomics and Phosphoproteomics

(2016) Liana Tsiatsiani et al.   JOURNAL OF PROTEOME RESEARCH

Six alternative proteases for mass spectrometry–based proteomics beyond trypsin

(2016) Piero Giansanti et al.   Nature Protocols

Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles

(2016) Olivier Julien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Termini and Their Modifications Revealed by Positional Proteomics

(2015) Giada Marino et al.   ACS Chemical Biology

N-terminal protein modifications: Bringing back into play the ribosome

(2015) Carmela Giglione et al.   BIOCHIMIE

Targeting the eIF4F Translation Initiation Complex: A Critical Nexus for Cancer Development

(2015) J. Pelletier et al.   CANCER RESEARCH

One-step site-specific modification of native proteins with 2-pyridinecarboxyaldehydes

(2015) James I MacDonald et al.   Nature Chemical Biology

N-terminome analysis of the human mitochondrial proteome

(2015) Alvaro Sebastian Vaca Jacome et al.   PROTEOMICS

GSK-3β-dependent downregulation of γ-taxilin and αNAC merge to regulate ER stress responses

(2015) Y Hotokezaka et al.   Cell Death & Disease

An Organellar Nα-Acetyltransferase, Naa60, Acetylates Cytosolic N Termini of Transmembrane Proteins and Maintains Golgi Integrity

(2015) Henriette Aksnes et al.   Cell Reports

BoxPlotR: a web tool for generation of box plots

(2014) Michaela Spitzer et al.   NATURE METHODS

Proteome TopFIND 3.0 with TopFINDer and PathFINDer: database and analysis tools for the association of protein termini to pre- and post-translational events

(2014) Nikolaus Fortelny et al.   NUCLEIC ACIDS RESEARCH

An Approach for Triplex-Isobaric Peptide Termini Labeling (Triplex-IPTL)

(2013) Christian J. Koehler et al.   ANALYTICAL CHEMISTRY

An Improved Stable Isotope N-Terminal Labeling Approach with Light/Heavy TMPP To Automate Proteogenomics Data Validation: dN-TOP

(2013) Diego Bertaccini et al.   JOURNAL OF PROTEOME RESEARCH

Proteolytic Post-translational Modification of Proteins: Proteomic Tools and Methodology

(2013) Lindsay D. Rogers et al.   MOLECULAR & CELLULAR PROTEOMICS

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

Proteomic Amino-Termini Profiling Reveals Targeting Information for Protein Import into Complex Plastids

(2013) Pitter F. Huesgen et al.   PLoS One

Mitochondrial inner membrane protease promotes assembly of presequence translocase by removing a carboxy-terminal targeting sequence

(2013) Raffaele Ieva et al.   Nature Communications

Functional Interplay between Caspase Cleavage and Phosphorylation Sculpts the Apoptotic Proteome

(2012) Melissa M. Dix et al.   CELL

Isobaric cross-sequence labeling of peptides by using site-selective N-terminus dimethylation

(2012) Hongqiang Qin et al.   CHEMICAL COMMUNICATIONS

Comparative Large Scale Characterization of PlantversusMammal Proteins Reveals Similar and IdiosyncraticN-α-Acetylation Features

(2012) Willy V. Bienvenut et al.   MOLECULAR & CELLULAR PROTEOMICS

The DegraBase: A Database of Proteolysis in Healthy and Apoptotic Human Cells

(2012) Emily D. Crawford et al.   MOLECULAR & CELLULAR PROTEOMICS

Global kinetic analysis of proteolysis via quantitative targeted proteomics

(2012) N. J. Agard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comet: An open-source MS/MS sequence database search tool

(2012) Jimmy K. Eng et al.   PROTEOMICS

Bioinformatics Analysis of aSaccharomyces cerevisiaeN-Terminal Proteome Provides Evidence of Alternative Translation Initiation and Post-Translational N-Terminal Acetylation

(2011) Kenny Helsens et al.   JOURNAL OF PROTEOME RESEARCH

Identifying and quantifying proteolytic events and the natural N terminome by terminal amine isotopic labeling of substrates

(2011) Oded Kleifeld et al.   Nature Protocols

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

(2011) N. D. Rawlings et al.   NUCLEIC ACIDS RESEARCH

Perturbation of the yeast N-acetyltransferase NatB induces elevation of protein phosphorylation levels

(2010) Andreas O Helbig et al.   BMC GENOMICS

Value of Using Multiple Proteases for Large-Scale Mass Spectrometry-Based Proteomics

(2010) Danielle L. Swaney et al.   JOURNAL OF PROTEOME RESEARCH

Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products

(2010) Oded Kleifeld et al.   NATURE BIOTECHNOLOGY

A guided tour of the Trans-Proteomic Pipeline

(2010) Eric W. Deutsch et al.   PROTEOMICS

N-Terminal Acetylation of Cellular Proteins Creates Specific Degradation Signals

(2010) C.-S. Hwang et al.   SCIENCE

αNAC depletion as an initiator of ER stress-induced apoptosis in hypoxia

(2009) Y Hotokezaka et al.   CELL DEATH AND DIFFERENTIATION

A proteomics approach to study in vivo protein Nα-modifications

(2009) Xumin Zhang et al.   Journal of Proteomics

Proteome-wide Substrate Analysis Indicates Substrate Exclusion as a Mechanism to Generate Caspase-7VersusCaspase-3 Specificity

(2009) Dieter Demon et al.   MOLECULAR & CELLULAR PROTEOMICS

Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans

(2009) T. Arnesen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global Sequencing of Proteolytic Cleavage Sites in Apoptosis by Specific Labeling of Protein N Termini

(2008) Sami Mahrus et al.   CELL

Proteases: Multifunctional Enzymes in Life and Disease

(2008) Carlos López-Otín et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sorting Signals, N-Terminal Modifications and Abundance of the Chloroplast Proteome

(2008) Boris Zybailov et al.   PLoS One

Executioner caspase-3 and caspase-7 are functionally distinct proteases

(2008) J. G. Walsh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear localized protein-1 (Nulp1) increases cell death of human osteosarcoma cells and binds the X-linked inhibitor of apoptosis protein

(2007) Håkan Steen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS