African Swine Fever Virus L83L Negatively Regulates the cGAS-STING-Mediated IFN-I Pathway by Recruiting Tollip To Promote STING Autophagic Degradation

Innate Sensors Trigger Regulated Cell Death to Combat Intracellular Infection

(2022) Kengo Nozaki et al.   Annual Review of Immunology

MGF360-9L Is a Major Virulence Factor Associated with the African Swine Fever Virus by Antagonizing the JAK/STAT Signaling Pathway

(2022) Keshan Zhang et al.   mBio

African Swine Fever Virus MGF360-14L Negatively Regulates Type I Interferon Signaling by Targeting IRF3

(2022) Yang Wang et al.   Frontiers in Cellular and Infection Microbiology

The A137R Protein of African Swine Fever Virus Inhibits Type I Interferon Production via the Autophagy-Mediated Lysosomal Degradation of TBK1

(2022) Maowen Sun et al.   JOURNAL OF VIROLOGY

Transcriptome profiling in swine macrophages infected with African swine fever virus at single-cell resolution

(2022) Yuxuan Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

I226R Protein of African Swine Fever Virus Is a Suppressor of Innate Antiviral Responses

(2022) Jinxuan Hong et al.   Viruses-Basel

The African swine fever virus protease pS273R inhibits DNA sensing cGAS-STING pathway by targeting IKKε

(2022) Jia Luo et al.   Virulence

The ORF7a protein of SARS-CoV-2 initiates autophagy and limits autophagosome-lysosome fusion via degradation of SNAP29 to promote virus replication

(2022) Peili Hou et al.   Autophagy

Inhibition of BET Family Proteins Suppresses African Swine Fever Virus Infection

(2022) Yaru Zhao et al.   Microbiology Spectrum

Endocytosis triggers V-ATPase-SYK–mediated priming of cGAS activation and innate immune response

(2022) Yu-Lin Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

African swine fever virus MGF505-7R protein interacted with IRF7and TBK1 to inhibit type I interferon production

(2022) Kaidian Yang et al.   VIRUS RESEARCH

African Swine Fever Virus MGF-505-7R Negatively Regulates cGAS–STING-Mediated Signaling Pathway

(2021) Dan Li et al.   JOURNAL OF IMMUNOLOGY

cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing

(2021) Wen Zhou et al.   MOLECULAR CELL

E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3

(2021) Peng Gao et al.   Nature Communications

The PB1 protein of influenza A virus inhibits the innate immune response by targeting MAVS for NBR1-mediated selective autophagic degradation

(2021) Yan Zeng et al.   PLoS Pathogens

Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion

(2021) Guangjun Xu et al.   MOLECULAR CELL

STING1 is essential for an RNA-virus triggered autophagy

(2021) Rui Zhang et al.   Autophagy

African swine fever virus protein MGF-505-7R promotes virulence and pathogenesis by inhibiting JAK1- and JAK2-mediated signaling

(2021) Dan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The protein arginine methyltransferase PRMT1 promotes TBK1 activation through asymmetric arginine methylation

(2021) Zhenzhen Yan et al.   Cell Reports

PCV2 targets cGAS to inhibit type I interferon induction to promote other DNA virus infection

(2021) Zhenyu Wang et al.   PLoS Pathogens

pMGF505-7R determines pathogenicity of African swine fever virus infection by inhibiting IL-1β and type I IFN production

(2021) Jiangnan Li et al.   PLoS Pathogens

Inhibition of USP14 influences alphaherpesvirus proliferation by degrading viral VP16 protein via ER stress-triggered selective autophagy

(2021) Sheng-Li Ming et al.   Autophagy

African Swine Fever Virus pI215L Negatively Regulates cGAS-STING Signaling Pathway through Recruiting RNF138 to Inhibit K63-Linked Ubiquitination of TBK1

(2021) Li Huang et al.   JOURNAL OF IMMUNOLOGY

African swine fever virus MGF505-11R inhibits type I interferon production by negatively regulating the cGAS-STING-mediated signaling pathway

(2021) Kaidian Yang et al.   VETERINARY MICROBIOLOGY

Transcriptome Profiling Reveals Features of Immune Response and Metabolism of Acutely Infected, Dead and Asymptomatic Infection of African Swine Fever Virus in Pigs

(2021) Hualin Sun et al.   Frontiers in Immunology

Cyclic GMP-AMP synthase is essential for cytosolic double-stranded DNA and fowl adenovirus serotype 4 triggered innate immune responses in chickens

(2020) Jiang Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP

(2020) Vladislav Pokatayev et al.   NATURE IMMUNOLOGY

Structures and Mechanisms in the cGAS-STING Innate Immunity Pathway

(2020) Xuewu Zhang et al.   IMMUNITY

Molecular and spatial mechanisms governing STING signalling

(2020) Katherine R. Balka et al.   FEBS Journal

β-arrestin 2 as an activator of cGAS-STING signaling and target of viral immune evasion

(2020) Yihua Zhang et al.   Nature Communications

Replication and virulence in pigs of the first African swine fever virus isolated in China

(2019) Dongming Zhao et al.   Emerging Microbes & Infections

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

(2019) Xiang Gui et al.   NATURE

African swine fever virus Armenia/07 virulent strain controls IFN-β production through cGAS-STING pathway

(2019) Raquel García-Belmonte et al.   JOURNAL OF VIROLOGY

African swine fever

(2019) L.K. Dixon et al.   ANTIVIRAL RESEARCH

Herpes Simplex Virus 1 Tegument Protein UL46 Inhibits TANK-Binding Kinase 1-Mediated Signaling

(2019) Hongjuan You et al.   mBio

Avian oncogenic herpesvirus antagonizes the cGAS-STING DNA-sensing pathway to mediate immune evasion

(2019) Kai Li et al.   PLoS Pathogens

Architecture of African swine fever virus and implications for viral assembly

(2019) Nan Wang et al.   SCIENCE

Cryo-EM Structure of the African Swine Fever Virus

(2019) Sheng Liu et al.   Cell Host & Microbe

Attenuation of cGAS‐STING signaling is mediated by a p62/SQSTM1‐dependent autophagy pathway activated by TBK1

(2018) Thaneas Prabakaran et al.   EMBO JOURNAL

Herpes Simplex Virus 1 Tegument Protein VP22 Abrogates cGAS/STING-Mediated Antiviral Innate Immunity

(2018) Jian Huang et al.   JOURNAL OF VIROLOGY

The L83L ORF of African swine fever virus strain Georgia encodes for a non-essential gene that interacts with the host protein IL-1β

(2018) Manuel V. Borca et al.   VIRUS RESEARCH

Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids

(2018) Xiaojun Tan et al.   Annual Review of Microbiology

Inhibition of cGAS-STING-TBK1 signaling pathway by DP96R of ASFV China 2018/1

(2018) Xixi Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway

(2018) Lele Zhang et al.   PLoS Pathogens

Herpes Simplex Virus 1 Abrogates the cGAS/STING-Mediated Cytosolic DNA-Sensing Pathway via Its Virion Host Shutoff Protein, UL41

(2017) Chenhe Su et al.   JOURNAL OF VIROLOGY

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE