The protein arginine methyltransferase PRMT1 promotes TBK1 activation through asymmetric arginine methylation

Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling

(2020) Patrick J. Metz et al.   Cell Reports

Zebrafish prmt3 negatively regulates antiviral responses

(2020) Junji Zhu et al.   FASEB JOURNAL

Histone deacetylase 3 promotes innate antiviral immunity through deacetylation of TBK1

(2020) Jie-lin Tang et al.   Protein & Cell

Nuclear cGAS Functions Non-canonically to Enhance Antiviral Immunity via Recruiting Methyltransferase Prmt5

(2020) Shufang Cui et al.   Cell Reports

Structural basis of STING binding with and phosphorylation by TBK1

(2019) Conggang Zhang et al.   NATURE

Zebrafish prmt7 negatively regulates antiviral responses by suppressing the retinoic acid‐inducible gene‐I‐like receptor signaling

(2019) Junji Zhu et al.   FASEB JOURNAL

The methyltransferase PRMT6 attenuates antiviral innate immunity by blocking TBK1–IRF3 signaling

(2018) Hua Zhang et al.   Cellular & Molecular Immunology

Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation

(2018) Jung-Hoon Pyun et al.   Nature Communications

Regulation of type I interferon signaling in immunity and inflammation: A comprehensive review

(2017) Kun Chen et al.   JOURNAL OF AUTOIMMUNITY

Small Molecule Inhibitors of Protein Arginine Methyltransferases

(2016) Hao Hu et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

E3 ubiquitin ligase RNF128 promotes innate antiviral immunity through K63-linked ubiquitination of TBK1

(2016) Guanhua Song et al.   NATURE IMMUNOLOGY

The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination

(2016) Bingyu Liu et al.   NATURE IMMUNOLOGY

PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca2+ uptake in immortalized cells

(2016) Corina T. Madreiter-Sokolowski et al.   Nature Communications

A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases

(2015) Mohammad S. Eram et al.   ACS Chemical Biology

PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response

(2015) Hsin-Wei Liao et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of the PRMT1v1 and PRMT1v2 specific interactomes by quantitative mass spectrometry in breast cancer cells

(2015) R. Mitchell Baldwin et al.   PROTEOMICS

TRIM26 Negatively Regulates Interferon-β Production and Antiviral Response through Polyubiquitination and Degradation of Nuclear IRF3

(2015) Peng Wang et al.   PLoS Pathogens

Structure and Ubiquitination-Dependent Activation of TANK-Binding Kinase 1

(2013) Daqi Tu et al.   Cell Reports

Nucleic Acid Sensors and Type I Interferon Production in Systemic Lupus Erythematosus

(2013) Meena Shrivastav et al.   Frontiers in Immunology

NEMO Binds Ubiquitinated TANK-Binding Kinase 1 (TBK1) to Regulate Innate Immune Responses to RNA Viruses

(2012) Lingyan Wang et al.   PLoS One

Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation

(2012) X. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

(2012) Y. Tanaka et al.   Science Signaling

MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

(2011) Fajian Hou et al.   CELL

Arginine methylation-dependent regulation of ASK1 signaling by PRMT1

(2011) J-H Cho et al.   CELL DEATH AND DIFFERENTIATION

RIG-I-like receptors: cytoplasmic sensors for non-self RNA

(2011) Hiroki Kato et al.   IMMUNOLOGICAL REVIEWS

Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt

(2011) J.-i. Sakamaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The TRAF-associated protein TANK facilitates cross-talk within the I B kinase family during Toll-like receptor signaling

(2011) K. Clark et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers

(2010) Masanori Yoshimatsu et al.   INTERNATIONAL JOURNAL OF CANCER

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Key Role of Ubc5 and Lysine-63 Polyubiquitination in Viral Activation of IRF3

(2009) Wenwen Zeng et al.   MOLECULAR CELL

Innate immunity to virus infection

(2008) Osamu Takeuchi et al.   IMMUNOLOGICAL REVIEWS