Article
Biochemistry & Molecular Biology
Kanit Bhukhai, Guillemette Fouquet, Yutthana Rittavee, Nopmullee Tanhuad, Chaiyaporn Lakmuang, Suparerk Borwornpinyo, Usanarat Anurathapan, Apichart Suksamrarn, Pawinee Piyachaturawat, Arthit Chairoungdua, Olivier Hermine, Suradej Hongeng
Summary: ASPP 049, a phytoestrogen diarylheptanoid isolated from Curcuma comosa, promotes erythropoiesis through activation of the Epo-Epo receptor (EpoR) complex, inducing EpoR-mediated erythropoiesis pathways and improving anemia symptoms.
Article
Physiology
Yihang Li, Ian Miller, Princy Prasad, Nisha Ajit George, Nermi L. Parrow, Robert E. Fleming
Summary: This study investigates the role of transferrin in the erythropoietic response to iron deficiency and iron deficiency anemia. The results demonstrate that transferrin not only plays a role in iron delivery but also affects iron homeostasis and erythropoiesis. Administration of exogenous iron-loaded transferrin restores iron levels and influences the expression of regulatory proteins involved in erythropoiesis. In iron deficiency anemia, transferrin treatment increases erythropoietin sensitivity, highlighting its importance in the recovery from iron deficiency anemia.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biology
Suhita Ray, Linda Chee, Yichao Zhou, Meg A. Schaefer, Michael J. Naldrett, Sophie Alvarez, Nicholas T. Woods, Kyle J. Hewitt
Summary: Acute anemia leads to expansion and differentiation of erythroid precursors, and the interaction between Samd14 and the F-actin capping protein (CP) complex determines the levels and function of erythroid precursor cells.
Article
Pharmacology & Pharmacy
Ryohei Kawasaki, Yoshihito Tashiro, Kenji Yogo, Kenichi Serizawa, Ken Aizawa, Koichi Endo, Michinori Hirata
Summary: The study investigated whether the prolonged duration of action of ESAs contributes to their renoprotective effects by comparing a divided administration of a short-acting ESA, epoetin beta (EPO), or a single administration of a long-acting ESA, epoetin beta pegol (continuous erythropoietin receptor activator; C.E.R.A.), to a single administration of EPO in chronic glomerulonephritis (GN) rats. The results showed that the prolonged duration of ESAs' action significantly contributed to their renoprotective effects by suppressing the exacerbation of urinary total protein levels in chronic GN rats.
Review
Biochemistry & Molecular Biology
Sayantani Sinha, Joana Pereira-Reis, Amaliris Guerra, Stefano Rivella, Delfim Duarte
Summary: Iron is essential for maintaining normal hematopoiesis and erythropoiesis, but excessive iron can lead to toxic effects. Recent advances involve understanding key iron regulators and the development of new drugs for hematological disorders. Future studies will need to continue exploring the role of iron in both normal and malignant hematopoiesis.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Physiology
Sanja Vignjevic Petrinovic, Aleksandra Jaukovic, Maja Milosevic, Diana Bugarski, Mirela Budec
Summary: Cancer-related anemia (CRA) is a common disorder that negatively affects the quality of life and prognosis in cancer patients. Stress erythropoiesis (SE) plays a pivotal role in CRA, but chronic SE may lead to ineffective erythropoiesis, worsening the condition. Therefore, there is an urgent need to control ineffective erythropoiesis in cancer patients and develop personalized treatment strategies for CRA management.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Milton Packer
Summary: SGLT2 inhibitors reduce the risk of heart failure events by enhancing erythropoiesis. This enhancement is hypothesized to be due to increased oxygenation in the kidneys, increased oxygen consumption and localized hypoxia, increased iron mobilization, and direct activation of erythropoietin gene transcription. The liver may also contribute to erythropoietin production during SGLT2 inhibition. The mechanism linking erythropoiesis to cardioprotection may involve the upregulation of SIRT1 and its effects on HIF-2 alpha expression and erythropoietin synthesis.
EUROPEAN HEART JOURNAL
(2023)
Article
Orthopedics
Huixin Chen, Jing Yu, Qing Wei, Yu Zhang, Xilin Ouyang, Shun Wang
Summary: The study aimed to assess the role of intravenous iron and erythropoietin therapy in rapid correction of postoperative anemia following orthopedic surgery. The results showed that the combined therapy did not significantly correct postoperative anemia compared to placebo. It is also suggested not to administer vitamin B-12 during the early postoperative period.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Physiology
Kornvipa Settakorn, Sarawut Kongkarnka, Anchan Chompupoung, Saovaros Svasti, Suthat Fucharoen, John B. Porter, Somdet Srichairatanakool, Pimpisid Koonyosying
Summary: This study found that green tea extract rich in epigallocatechin-3-gallate has positive effects in alleviating ineffective erythropoiesis, iron dysregulation, and oxidative stress in beta-thalassemic mice.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Simon Grootendorst, Jonathan de Wilde, Birgit van Dooijeweert, Annelies van Vuren, Wouter van Solinge, Roger Schutgens, Richard van Wijk, Marije Bartels
Summary: Rare hereditary anemias (RHA) are characterized by impaired red blood cell production or decreased survival, often leading to disturbances in iron metabolism and erythropoiesis, resulting in iron overload or exacerbation of chronic anemia. Iron overload is a significant issue in both transfusion-dependent and non-transfusion-dependent patients with RHA, suggesting common defects in erythroid development linked to intrinsic iron metabolism defects. Key regulators involved in the interaction between iron and erythropoiesis are discussed in the context of RHA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Md Yousuf Ali, Claudia R. Oliva, Susanne Flor, Corinne E. Griguer
Summary: Iron is crucial for cellular processes, but maintaining iron homeostasis is essential for balanced cellular signaling and disease prevention. Mitoferrins, as the principal iron importers in human cell mitochondria, play a critical role in maintaining cytosolic and mitochondrial iron homeostasis.
Article
Environmental Sciences
Chun Pan, Minghao Yan, Haibo Jin, Hongqian Guo, Xiaodong Han
Summary: The study found that microcystins play an important role in human hematological parameters, potentially leading to microcytic anemia, and identified the related signaling pathway for the first time.
ENVIRONMENTAL POLLUTION
(2021)
Review
Biochemistry & Molecular Biology
Zuzana Tothova, Jana Tomc, Natasa Debeljak, Peter Solar
Summary: Erythropoietin acts on multiple tissues through the receptor EPOR, triggering various signaling pathways such as JAK2/STAT5 and PI3K/AKT that regulate erythropoiesis and cell functions, with potential implications for cancer research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Tomas Ganz, Francesco Locatelli, Mustafa Arici, Tadao Akizawa, Michael Reusch
Summary: Roxadustat has a distinct impact on iron parameters and hemoglobin levels compared to erythropoiesis-stimulating agents (ESAs). It decreases serum ferritin levels to a greater extent and increases serum iron levels instead of decreasing them. The decrease in transferrin saturation in patients treated with Roxadustat is relatively small and is not observed in non-dialysis or dialysis-dependent chronic kidney disease (CKD) patients by Week 52. Roxadustat improves iron availability, increases erythropoiesis, and requires less intravenous iron use compared to placebo and ESA. Hepcidin levels generally decrease more significantly with Roxadustat than with ESA or placebo. The mechanisms underlying the effects of Roxadustat and ESAs on iron availability, stores, and erythropoiesis differ and should be considered holistically when treating CKD anemia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Chemistry, Medicinal
Farooqahmed S. Kittur, Chiu-Yueh Hung, P. Andy Li, David C. Sane, Jiahua Xie
Summary: Neuroprotective drugs for cerebral ischemia and reperfusion (I/R) injury are urgently needed, but the clinical translation of recombinant human erythropoietin (rhuEPO(M)) has been inconsistent due to side effects. Asialo-rhuEPO, a non-erythropoietic derivative, has shown neuroprotective effects and can be prepared by removing sialic acid residues. Both types of asialo-rhuEPO showed excellent neuroprotective effects in animal models, and future studies are needed to develop it as a multimodal neuroprotectant for ischemic stroke treatment.
Article
Surgery
Tyler J. Loftus, Megan L. Morrow, Lawrence Lottenberg, Martin D. Rosenthal, Chasen A. Croft, R. Stephen Smith, Frederick A. Moore, Scott C. Brakenridge, Robert Borrego, Philip A. Efron, Alicia M. Mohr
WORLD JOURNAL OF SURGERY
(2019)
Article
Surgery
Tyler J. Loftus, Megan L. Morrow, Lawrence Lottenberg, Martin D. Rosenthal, Chasen A. Croft, R. Stephen Smith, Frederick A. Moore, Scott C. Brakenridge, Robert Borrego, Philip A. Efron, Alicia M. Mohr
AMERICAN JOURNAL OF SURGERY
(2019)
Article
Critical Care Medicine
Tyler J. Loftus, Juan C. Mira, Julie A. Stortz, Tezcan Ozrazgat-Baslanti, Gabriella L. Ghita, Zhongkai Wang, Babette A. Brumback, Ricardo F. Ungaro, Azra Bihorac, Christiaan Leeuwenburgh, Frederick A. Moore, Lyle L. Moldawer, Scott C. Brakenridge, Philip A. Efron, Alicia M. Mohr
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2019)
Article
Critical Care Medicine
Tyler J. Loftus, Philip A. Efron, Trina M. Bala, Martin D. Rosenthal, Chasen A. Croft, Michael S. Walters, R. Stephen Smith, Frederick A. Moore, Alicia M. Mohr, Scott C. Brakenridge
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2019)
Article
Surgery
Scott C. Brakenridge, Frederick A. Moore, Nicole R. Mercier, Michael Cox, Quron Wu, Lyle L. Moldawer, Alicia M. Mohr, Philip A. Efron, R. Stephen Smith
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2019)
Article
Surgery
Elizabeth S. Miller, Camille G. Apple, Kolenkode B. Kannan, Zackary M. Funk, Jessica M. Plazas, Philip A. Efron, Alicia M. Mohr
AMERICAN JOURNAL OF SURGERY
(2019)
Article
Surgery
Scott C. Brakenridge, Philip A. Efron, Michael C. Cox, Julie A. Stortz, Russell B. Hawkins, Gabriela Ghita, Anna Gardner, Alicia M. Mohr, Stephen D. Anton, Lyle L. Moldawer, Frederick A. Moore
Article
Surgery
Elizabeth S. Miller, Tyler J. Loftus, Kolenkode B. Kannan, Jessica M. Plazas, Philip A. Efron, Alicia M. Mohr
JOURNAL OF SURGICAL RESEARCH
(2019)
Article
Surgery
Camille G. Apple, Elizabeth S. Miller, Tyler J. Loftus, Kolenkode B. Kannan, Chase W. Thompson, Maria Cecilia Lopez, Henry V. Baker, Lyle L. Moldawer, Philip A. Efron, Alicia M. Mohr
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2020)
Article
Surgery
Elizabeth S. Miller, Camille G. Apple, Kolenkode B. Kannan, Zackary M. Funk, Philip A. Efron, Alicia M. Mohr
AMERICAN JOURNAL OF SURGERY
(2020)
Article
Surgery
Michael C. Cox, Scott C. Brakenridge, Julie A. Stortz, Russell B. Hawkins, Dijoa B. Darden, Gabriela L. Ghita, Alicia M. Mohr, Lyle L. Moldawer, Philip A. Efron, Frederick A. Moore
AMERICAN JOURNAL OF SURGERY
(2020)
Review
Medicine, General & Internal
Dijoia B. Darden, Lauren S. Kelly, Brittany P. Fenner, Lyle L. Moldawer, Alicia M. Mohr, Philip A. Efron
Summary: Protocolized surveillance, diagnosis, and management of septic patients, especially surgical sepsis patients, can significantly increase the number of patients surviving their initial hospitalization. However, some patients may develop chronic critical illness, with elderly and comorbid patients being particularly susceptible to poor outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Ethan D. Carmichael, Camille G. Apple, Kolenkode B. Kannan, Anna Gardener, Stephen Anton, Philip A. Efron, Lyle L. Moldawer, Frederick A. Moore, Scott C. Brakenridge, Alicia M. Mohr
Summary: This study found that survivors of sepsis may either experience rapid recovery or enter a state of chronic critical illness. Anemia is known to be an important factor in the functional recovery of hospitalized patients. Prolonged inflammation may contribute to persistent anemia and poor functional outcomes.
Article
Surgery
Lauren S. Kelly, Kolenkode B. Kannan, Jennifer A. Munley, Erick E. Pons, Hari K. Parvataneni, Jennifer E. Hagen, Philip A. Efron, Alicia M. Mohr
Summary: This study investigated the levels of adipokines and their impact on erythroid suppression in trauma patients. The results showed decreased adiponectin and increased leptin and resistin in trauma patients, with variations by age and sex. The study found a negative correlation between adipokine suppression and erythroid progenitor growth.
Article
Critical Care Medicine
McKenzie K. Hollen, Julie A. Stortz, Dijoia Darden, Marvin L. Dirain, Dina C. Nacionales, Russell B. Hawkins, Michael C. Cox, Maria-Cecilia Lopez, Jaimar C. Rincon, Ricardo Ungaro, Zhongkai Wang, Quran Wu, Babette Brumback, Marie-Pierre L. Gauthier, Michael Kladde, Christiaan Leeuwenburgh, Mark Segal, Azra Bihorac, Scott Brakenridge, Frederick A. Moore, Henry Baker, Alicia M. Mohr, Lyle L. Moldawer, Philip A. Efron