IL-17 mediates inflammatory reactions via p38/c-Fos and JNK/c-Jun activation in an AP-1-dependent manner in human nucleus pulposus cells

Advancing the cellular and molecular therapy for intervertebral disc disease

(2015) Daisuke Sakai et al.   ADVANCED DRUG DELIVERY REVIEWS

Symptomatic versus Asymptomatic Intervertebral Disc Degeneration: Is Inflammation the Key?

(2015) Yan Peng et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Reduced tonicity stimulates an inflammatory response in nucleus pulposus tissue that can be limited by a COX-2-specific inhibitor

(2015) Bart van Dijk et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Inflammation in intervertebral disc degeneration and regeneration

(2015) M. Molinos et al.   Journal of the Royal Society Interface

TLR2 Involved in Naive CD4+ T Cells Rescues Stress-Induced Immune Suppression by Regulating Th1/Th2 and Th17

(2015) Jing Zhao et al.   NEUROIMMUNOMODULATION

Control of IL-17 receptor signaling and tissue inflammation by the p38α–MKP-1 signaling axis in a mouse model of multiple sclerosis

(2015) Gonghua Huang et al.   Science Signaling

Integrating p38α MAPK immune signals in nonimmune cells

(2015) Sarah L. Gaffen et al.   Science Signaling

Control of IL-17 receptor signaling and tissue inflammation by the p38α–MKP-1 signaling axis in a mouse model of multiple sclerosis

(2015) Gonghua Huang et al.   Science Signaling

Integrating p38α MAPK immune signals in nonimmune cells

(2015) Sarah L. Gaffen et al.   Science Signaling

Interleukin-17 Receptor A Signaling in Transformed Enterocytes Promotes Early Colorectal Tumorigenesis

(2014) Kepeng Wang et al.   IMMUNITY

IL-17 stimulates the production of the inflammatory chemokines IL-6 and IL-8 in human dental pulp fibroblasts

(2014) H. Xiong et al.   INTERNATIONAL ENDODONTIC JOURNAL

Th17 Cell Frequency and IL-17 Concentration Correlate With Pre- and Postoperative Pain Sensation in Patients With Intervertebral Disk Degeneration

(2014) Wen Zhang et al.   ORTHOPEDICS

Discogenic Low Back Pain

(2014) Jeremy Simon et al.   Physical Medicine and Rehabilitation Clinics of North America

Eupafolin inhibits PGE2 production and COX2 expression in LPS-stimulated human dermal fibroblasts by blocking JNK/AP-1 and Nox2/p47phox pathway

(2014) Ming-Horng Tsai et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Autoimmunity in intervertebral disc herniation: from bench to bedside

(2013) Alberto Di Martino et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Th17 lymphocyte levels are higher in patients with ruptured than non-ruptured lumbar discs, and are correlated with pain intensity

(2013) Lei Cheng et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

CCL20 Secretion from the Nucleus Pulposus Improves the Recruitment of CCR6-Expressing Th17 Cells to Degenerated IVD Tissues

(2013) Wen Zhang et al.   PLoS One

C-Fos Regulation by the MAPK and PKC Pathways in Intervertebral Disc Cells

(2013) Katsuya Yokoyama et al.   PLoS One

Intervertebral disc and macrophage interaction induces mechanical hyperalgesia and cytokine production in a herniated disc model in rats

(2012) Toru Takada et al.   ARTHRITIS AND RHEUMATISM

A systematic review of the global prevalence of low back pain

(2012) Damian Hoy et al.   ARTHRITIS AND RHEUMATISM

Tumor necrosis factor-α levels correlate with postoperative pain severity in lumbar disc hernia patients: Opposite clinical effects between tumor necrosis factor receptor 1 and 2

(2011) Pablo Andrade et al.   PAIN

Enhancement of intervertebral disc cell senescence by WNT/β-catenin signaling-induced matrix metalloproteinase expression

(2010) Akihiko Hiyama et al.   ARTHRITIS AND RHEUMATISM

IL-17 Enhancement of the IL-6 Signaling Cascade in Astrocytes

(2010) X. Ma et al.   JOURNAL OF IMMUNOLOGY

Interleukin-17 synergizes with IFNγ or TNFα to promote inflammatory mediator release and intercellular adhesion molecule-1 (ICAM-1) expression in human intervertebral disc cells

(2010) Mostafa A. Gabr et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Translational Mini-Review Series on Th17 Cells: Function and regulation of human T helper 17 cells in health and disease

(2009) S. Q. Crome et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Interleukin-23/Th17 pathways and inflammatory bowel disease

(2009) Clara Abraham et al.   INFLAMMATORY BOWEL DISEASES

p38 MAPK inhibition selectively mitigates inflammatory mediators and VEGF production in AF cells co-cultured with activated macrophage-like THP-1 cells

(2009) J.H. Kim et al.   OSTEOARTHRITIS AND CARTILAGE

Role of the tumor necrosis factor-α, cyclooxygenase-2, prostaglandin E2, and effect of low-intensity pulsed ultrasound in an in vitro herniated disc resorption model

(2008) Sadahiro Iwabuchi et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

p38 MAPK inhibition modulates rabbit nucleus pulposus cell response to IL-1

(2008) Rebecca K. Studer et al.   JOURNAL OF ORTHOPAEDIC RESEARCH