Small-Molecule Ferritin Degrader as a Pyroptosis Inducer

PROTAC targeted protein degraders: the past is prologue

(2022) Miklós Békés et al.   NATURE REVIEWS DRUG DISCOVERY

Ispinesib as an Effective Warhead for the Design of Autophagosome-Tethering Chimeras: Discovery of Potent Degraders of Nicotinamide Phosphoribosyltransferase (NAMPT)

(2022) Guoqiang Dong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Channelling inflammation: gasdermins in physiology and disease

(2021) Xing Liu et al.   NATURE REVIEWS DRUG DISCOVERY

Semiconducting polymer nano-PROTACs for activatable photo-immunometabolic cancer therapy

(2021) Chi Zhang et al.   Nature Communications

Dietary fats high in linoleic acids impair anti-tumor T cell responses by inducing E-FABP-mediated mitochondrial dysfunction

(2021) Rong Jin et al.   CANCER RESEARCH

A mutant T1 lipase homology modeling, and its molecular docking and molecular dynamics simulation with fatty acids

(2021) Xiaoli Qin et al.   JOURNAL OF BIOTECHNOLOGY

Persister cancer cells: Iron addiction and vulnerability to ferroptosis

(2021) Raphaël Rodriguez et al.   MOLECULAR CELL

Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation

(2020) Ross A. Weber et al.   MOLECULAR CELL

Revealing the toxicity of dimethyl phthalate (DMP) to the oxygen-carrying function of red blood cells (RBCs): The iron release mechanism

(2020) Zhenxing Chi et al.   CHEMOSPHERE

Discovery of an orally active VHL-recruiting PROTAC that achieves robust HMGCR degradation and potent hypolipidemic activity in vivo

(2020) Guoshun Luo et al.   Acta Pharmaceutica Sinica B

SLC3A2/CD98hc, autophagy and tumor radioresistance: a link confirmed

(2019) David Digomann et al.   Autophagy

A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo

(2019) Longchuan Bai et al.   CANCER CELL

The chemical basis of ferroptosis

(2019) Marcus Conrad et al.   Nature Chemical Biology

Structure-Based Design of a Macrocyclic PROTAC

(2019) Andrea Testa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Emerging Strategies of Cancer Therapy Based on Ferroptosis

(2018) Zheyu Shen et al.   ADVANCED MATERIALS

Palmitic and Oleic Acid: The Yin and Yang of Fatty Acids in Type 2 Diabetes Mellitus

(2018) Xavier Palomer et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Harnessing albumin as a carrier for cancer therapies

(2018) Ella N. Hoogenboezem et al.   ADVANCED DRUG DELIVERY REVIEWS

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis 

(2018) Bo Zhou et al.   CELL RESEARCH

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Targeting iron metabolism in drug discovery and delivery

(2017) Bart J. Crielaard et al.   NATURE REVIEWS DRUG DISCOVERY

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL

(2015) Ashton C. Lai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Solid microparticles based on chitosan or methyl-β-cyclodextrin: A first formulative approach to increase the nose-to-brain transport of deferoxamine mesylate

(2015) Giovanna Rassu et al.   JOURNAL OF CONTROLLED RELEASE

Catalytic in vivo protein knockdown by small-molecule PROTACs

(2015) Daniel P Bondeson et al.   Nature Chemical Biology

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Unearthing the secrets of mitochondrial ROS and glutathione in bioenergetics

(2013) Ryan J. Mailloux et al.   TRENDS IN BIOCHEMICAL SCIENCES

The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK)

(2012) Christopher W. Davies et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ferritin couples iron and fatty acid metabolism

(2012) Weiming Bu et al.   FASEB JOURNAL

Albumin as Fatty Acid Transporter

(2009) Ger J. van der Vusse   Drug Metabolism and Pharmacokinetics

Ferritin for the clinician

(2008) Mary Ann Knovich et al.   BLOOD REVIEWS