Room-Temperature Cu-Catalyzed Amination of Aryl Bromides Enabled by DFT-Guided Ligand Design

Pilot Study to Quantify Palladium Impurities in Lead-like Compounds Following Commonly Used Purification Techniques

(2022) Maria Chatzopoulou et al.   ACS Medicinal Chemistry Letters

Cu-Mediated Ullmann-Type Cross-Coupling and Industrial Applications in Route Design, Process Development, and Scale-up of Pharmaceutical and Agrochemical Processes

(2022) Qiang Yang et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Oxalamide/Amide Ligands: Enhanced and Copper-Catalyzed C–N Cross-Coupling for Triarylamine Synthesis

(2022) Sasa Li et al.   ORGANIC LETTERS

Polymer Hole Transport Materials for Perovskite Solar Cells via Buchwald–Hartwig Amination

(2021) Daniel D. Astridge et al.   ACS Applied Polymer Materials

Development of an Aryl Amination Catalyst with Broad Scope Guided by Consideration of Catalyst Stability

(2020) Scott D. McCann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cu-Catalyzed C–N Coupling with Sterically Hindered Partners

(2020) Atanu Modak et al.   ACS Catalysis

Development of a Convergent Large-Scale Synthesis for Venetoclax, a First-in-Class BCL-2 Selective Inhibitor

(2019) Yi-Yin Ku et al.   JOURNAL OF ORGANIC CHEMISTRY

Pharmaceutical diversification via palladium oxidative addition complexes

(2019) Mycah R. Uehling et al.   SCIENCE

Biaryl monophosphine ligands in palladium-catalyzed C–N coupling: An updated User's guide

(2019) Bryan T. Ingoglia et al.   TETRAHEDRON

Tunable Surface Area, Porosity, and Function in Conjugated Microporous Polymers

(2019) Jie Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Data-Rich Experimentation Enables Palladium-Catalyzed Couplings of Piperidines and Five-Membered (Hetero)aromatic Electrophiles

(2019) Aaron C. Sather et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Cu-Catalyzed Couplings of Heteroaryl Primary Amines and (Hetero)aryl Bromides with 6-Hydroxypicolinamide Ligands

(2019) David J. Bernhardson et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Cu/N,N′-Dibenzyloxalamide-Catalyzed N-Arylation of Heteroanilines

(2019) Zhixiang Chen et al.   ORGANIC LETTERS

Mapping the dark space of chemical reactions with extended nanomole synthesis and MALDI-TOF MS

(2018) Shishi Lin et al.   SCIENCE

Palladium-Catalyzed Cross-Coupling Reactions: A Powerful Tool for the Synthesis of Agrochemicals

(2018) Ponnam Devendar et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Buchwald-Hartwig Coupling at the Naphthalenediimide Core: Access to Dendritic, Panchromatic NIR Absorbers with Exceptionally Low Band Gap

(2018) Jyoti Shukla et al.   ORGANIC LETTERS

Discovery of N-(Naphthalen-1-yl)-N′-alkyl Oxalamide Ligands Enables Cu-Catalyzed Aryl Amination with High Turnovers

(2017) Jie Gao et al.   ORGANIC LETTERS

Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions

(2016) Paula Ruiz-Castillo et al.   CHEMICAL REVIEWS

Transition-metal catalysed C–N bond activation

(2016) Quanjun Wang et al.   CHEMICAL SOCIETY REVIEWS

Chemistry informer libraries: a chemoinformatics enabled approach to evaluate and advance synthetic methods

(2016) Peter S. Kutchukian et al.   Chemical Science

Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?

(2015) Dean G. Brown et al.   JOURNAL OF MEDICINAL CHEMISTRY

CuI/Oxalic Diamide Catalyzed Coupling Reaction of (Hetero)Aryl Chlorides and Amines

(2015) Wei Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Assembly of Primary (Hetero)Arylamines via CuI/Oxalic Diamide-Catalyzed Coupling of Aryl Chlorides and Ammonia

(2015) Mengyang Fan et al.   ORGANIC LETTERS

Multi-Kilo Delivery of AMG 925 Featuring a Buchwald–Hartwig Amination and Processing with Insoluble Synthetic Intermediates

(2015) Caroline Affouard et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Distortion/Interaction Analysis Reveals the Origins of Selectivities in Iridium-Catalyzed C–H Borylation of Substituted Arenes and 5-Membered Heterocycles

(2014) Aaron G. Green et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Kiloscale Buchwald–Hartwig Amination: Optimized Coupling of Base-Sensitive 6-Bromoisoquinoline-1-carbonitrile with (S)-3-Amino-2-methylpropan-1-ol

(2014) Jeffrey B. Sperry et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Cu(I)/Cu(III) catalytic cycle involved in Ullmann-type cross-coupling reactions

(2014) Xavi Ribas et al.   PURE AND APPLIED CHEMISTRY

Synthesis of (−)-Epi-Indolactam V by an Intramolecular Buchwald–Hartwig C–N Coupling Cyclization Reaction

(2013) Michele Mari et al.   JOURNAL OF ORGANIC CHEMISTRY

The role of organometallic copper(iii) complexes in homogeneous catalysis

(2013) Alicia Casitas et al.   Chemical Science

Catalyst-Controlled Chemoselective Arylation of 2-Aminobenzimidazoles

(2012) Satoshi Ueda et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CuI/DMPAO-Catalyzed N-Arylation of Acyclic Secondary Amines

(2012) Yu Zhang et al.   ORGANIC LETTERS

Total Synthesis Guided Structure Elucidation of (+)-Psychotetramine

(2011) Klement Foo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Total Synthesis and Studies into the Configurational Stability of Bismurrayaquinone A

(2011) Leah C. Konkol et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

(2011) Stephen D. Roughley et al.   JOURNAL OF MEDICINAL CHEMISTRY

A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu

(2010) Stefan Grimme et al.   JOURNAL OF CHEMICAL PHYSICS

Diamine ligands in copper-catalyzed reactions

(2010) David S. Surry et al.   Chemical Science

Dialkylbiaryl phosphines in Pd-catalyzed amination: a user's guide

(2010) David S. Surry et al.   Chemical Science

Room-Temperature Copper-Catalyzed Carbon-Nitrogen Coupling of Aryl Iodides and Bromides Promoted by Organic Ionic Bases

(2009) Chu-Ting Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Suzuki−Miyaura Cross-Coupling Reactions Employing Dialkylbiaryl Phosphine Ligands

(2008) Ruben Martin et al.   ACCOUNTS OF CHEMICAL RESEARCH

Biaryl Phosphane Ligands in Palladium-Catalyzed Amination

(2008) David S. Surry et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION