Pharmaceutical diversification via palladium oxidative addition complexes

Palladium(II)-Mediated C−H Tritiation of Complex Pharmaceuticals

(2018) Haifeng Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A platform for automated nanomole-scale reaction screening and micromole-scale synthesis in flow

(2018) Damith Perera et al.   SCIENCE

Nanoscale synthesis and affinity ranking

(2018) Nathan J. Gesmundo et al.   NATURE

β-Carboline Amides as Intrinsic Directing Groups for C(sp2)–H Functionalization

(2017) Hélène M.-F. Viart et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stoichiometric and Catalytic Aryl–Perfluoroalkyl Coupling at Tri-tert-butylphosphine Palladium(II) Complexes

(2017) Devin M. Ferguson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct palladium-mediated on-resin disulfide formation from Allocam protected peptides

(2017) Thilini D. Kondasinghe et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Water-Soluble Palladium Reagents for Cysteine S-Arylation under Ambient Aqueous Conditions

(2017) Anthony J. Rojas et al.   ORGANIC LETTERS

Oxidative Addition Complexes as Precatalysts for Cross-Coupling Reactions Requiring Extremely Bulky Biarylphosphine Ligands

(2017) Bryan T. Ingoglia et al.   ORGANIC LETTERS

Divergent unprotected peptide macrocyclisation by palladium-mediated cysteine arylation

(2017) Anthony J. Rojas et al.   Chemical Science

Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions

(2016) Paula Ruiz-Castillo et al.   CHEMICAL REVIEWS

Big Data from Pharmaceutical Patents: A Computational Analysis of Medicinal Chemists’ Bread and Butter

(2016) Nadine Schneider et al.   JOURNAL OF MEDICINAL CHEMISTRY

New ligands for nickel catalysis from diverse pharmaceutical heterocycle libraries

(2016) Eric C. Hansen et al.   Nature Chemistry

Aryl amination using ligand-free Ni(II) salts and photoredox catalysis

(2016) Emily B. Corcoran et al.   SCIENCE

Chemistry informer libraries: a chemoinformatics enabled approach to evaluate and advance synthetic methods

(2016) Peter S. Kutchukian et al.   Chemical Science

Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?

(2015) Dean G. Brown et al.   JOURNAL OF MEDICINAL CHEMISTRY

Efficient 11C-Carbonylation of Isolated Aryl Palladium Complexes for PET: Application to Challenging Radiopharmaceutical Synthesis

(2015) Thomas L. Andersen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organometallic palladium reagents for cysteine bioconjugation

(2015) Ekaterina V. Vinogradova et al.   NATURE

Pd(ii) coordinated deprotonated diphenyl phosphino amino pyridine: reactivity towards solvent, base, and acid

(2014) Sanjay Pratihar et al.   DALTON TRANSACTIONS

Structure and reactivity of [(L·Pd) n ·(1,5-cyclooctadiene)] ( n = 1–2) complexes bearing biaryl phosphine ligands

(2014) Hong Geun Lee et al.   INORGANICA CHIMICA ACTA

Modeling a Crowdsourced Definition of Molecular Complexity

(2014) Robert P. Sheridan et al.   Journal of Chemical Information and Modeling

Nanomole-scale high-throughput chemistry for the synthesis of complex molecules

(2014) A. Buitrago Santanilla et al.   SCIENCE

A remote-controlled adaptive medchem lab: an innovative approach to enable drug discovery in the 21st Century

(2013) Alexander G. Godfrey et al.   DRUG DISCOVERY TODAY

Suzuki-Miyaura Cross-Coupling of Unprotected, Nitrogen-Rich Heterocycles: Substrate Scope and Mechanistic Investigation

(2013) M. Alexander Düfert et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Preparation of Allyl and Vinyl Silanes by the Palladium-Catalyzed Silylation of Terminal Olefins: A Silyl-Heck Reaction

(2012) Jesse R. McAtee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lead-Oriented Synthesis: A New Opportunity for Synthetic Chemistry

(2012) Alan Nadin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design and preparation of new palladium precatalysts for C–C and C–N cross-coupling reactions

(2012) Nicholas C. Bruno et al.   Chemical Science

Pd-Catalyzed Synthesis of ArSCF3 Compounds under Mild Conditions

(2011) Georgiy Teverovskiy et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Storable Arylpalladium(II) Reagents for Alkene Labeling in Aqueous Media

(2011) Rebecca L. Simmons et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Fluoride-Derived Electrophilic Late-Stage Fluorination Reagent for PET Imaging

(2011) E. Lee et al.   SCIENCE

Recyclable Heterogeneous Iron Catalyst for C−N Cross-Coupling under Ligand-Free Conditions

(2009) K. Swapna et al.   JOURNAL OF ORGANIC CHEMISTRY

Evolution of a Fourth Generation Catalyst for the Amination and Thioetherification of Aryl Halides

(2008) John F. Hartwig   ACCOUNTS OF CHEMICAL RESEARCH