P2 receptors and platelet function

Extracellular Ca2+ modulates ADP-evoked aggregation through altered agonist degradation: implications for conditions used to study P2Y receptor activation

(2011) Sarah Jones et al.   BRITISH JOURNAL OF HAEMATOLOGY

Ticagrelor

(2011) James J. Nawarskas et al.   Cardiology in Review

Major Contribution of the P2Y 1 Receptor in Purinergic Regulation of TNFα-Induced Vascular Inflammation

(2011) Murielle Zerr et al.   CIRCULATION

Pharmacology and clinical trials of reversibly-binding P2Y12 inhibitors

(2011) Robert Storey   THROMBOSIS AND HAEMOSTASIS

Ticagrelor Effectively and Reversibly Blocks Murine Platelet P2Y 12 -Mediated Thrombosis and Demonstrates a Requirement for Sustained P2Y 12 Inhibition to Prevent Subsequent Neointima

(2010) Shankar B. Patil et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Platelets

(2010) Shashank Jain et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Benzofuran-substituted urea derivatives as novel P2Y1 receptor antagonists

(2010) Reema K. Thalji et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Deletion of the p110  isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo

(2010) V. Martin et al.   BLOOD

The platelet P2Y12 receptor for adenosine diphosphate: congenital and drug-induced defects

(2010) M. Cattaneo   BLOOD

New P2Y 12 Inhibitors

(2010) Marco Cattaneo   CIRCULATION

P2Y nucleotide receptors: promise of therapeutic applications

(2010) Kenneth A. Jacobson et al.   DRUG DISCOVERY TODAY

Prasugrel for the treatment of coronary thrombosis: a review of pharmacological properties, indications for use and future development

(2010) Salvatore D Tomasello et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Ticagrelor for the treatment of arterial thrombosis

(2010) Paul A Gurbel et al.   EXPERT OPINION ON PHARMACOTHERAPY

Purinergic receptor agonists modulate phagocytosis and clearance of apoptotic cells in macrophages

(2010) Camila Marques-da-Silva et al.   IMMUNOBIOLOGY

The platelet contribution to cancer progression

(2010) N. M. BAMBACE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Quantification of recombinant and platelet P2Y1 receptors utilizing a [125I]-labeled high-affinity antagonist 2-iodo-N6-methyl-(N)-methanocarba-2′-deoxyadenosine-3′,5′-bisphosphate ([125I]MRS2500)

(2010) Philippe Ohlmann et al.   PHARMACOLOGICAL RESEARCH

Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production

(2010) E. Boilard et al.   SCIENCE

Platelets in defense against bacterial pathogens

(2009) Michael R. Yeaman   CELLULAR AND MOLECULAR LIFE SCIENCES

New P2Y12 antagonists

(2009) Alan D Michelson   CURRENT OPINION IN HEMATOLOGY

The reversible oral P2Y12 antagonist AZD6140 inhibits ADP-induced contractions in murine and human vasculature

(2009) Carl Högberg et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Leukotriene E4–induced pulmonary inflammation is mediated by the P2Y12receptor

(2009) Sailaja Paruchuri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Clopidogrel attenuates atheroma formation and induces a stable plaque phenotype in apolipoprotein E knockout mice

(2009) Arnon Afek et al.   MICROVASCULAR RESEARCH

 -Arrestin-2 Interaction and Internalization of the Human P2Y1 Receptor Are Dependent on C-Terminal Phosphorylation Sites

(2009) S. Reiner et al.   MOLECULAR PHARMACOLOGY

Prasugrel in Clinical Practice

(2009) Deepak L. Bhatt   NEW ENGLAND JOURNAL OF MEDICINE

Platelets Kill Intraerythrocytic Malarial Parasites and Mediate Survival to Infection

(2009) B. J. McMorran et al.   SCIENCE

Tetrahydro-4-quinolinamines identified as novel P2Y1 receptor antagonists

(2008) Ángel I. Morales-Ramos et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

P2Y1 receptor antagonists as novel antithrombotic agents

(2008) Jeffrey A. Pfefferkorn et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Reduced Atherosclerotic Lesions in P2Y 1 /Apolipoprotein E Double-Knockout Mice

(2008) Béatrice Hechler et al.   CIRCULATION

Platelet P2Y 12 Receptor Influences the Vessel Wall Response to Arterial Injury and Thrombosis

(2008) D.J.W. Evans et al.   CIRCULATION

ADP Stimulates Human Endothelial Cell Migration via P2Y 1 Nucleotide Receptor–Mediated Mitogen-Activated Protein Kinase Pathways

(2008) Jianzhong Shen et al.   CIRCULATION RESEARCH

Platelet reactivity and clopidogrel resistance are associated with the H2 haplotype of the P2Y12-ADP receptor gene

(2008) Peter Staritz et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Agonist-selective, Receptor-specific Interaction of Human P2YReceptors with β-Arrestin-1 and -2

(2008) Carsten Hoffmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Triggers, targets and treatments for thrombosis

(2008) Nigel Mackman   NATURE

Purinergic receptor P2Y, G-protein coupled, 12 gene variants and risk of incident ischemic stroke, myocardial infarction, and venous thromboembolism

(2007) Robert Y.L. Zee et al.   ATHEROSCLEROSIS

Pharmacological characterization of nucleotide P2Y receptors on endothelial cells of the mouse aorta

(2005) Pieter-Jan D F Guns et al.   BRITISH JOURNAL OF PHARMACOLOGY